Paula Miotto

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.

Justin P Hardee, Karen JB Martins, Paula M Miotto, James G Ryall, Stefan M Gehrig, Boris Reljic, Timur Naim, Jin D Chung, Jen Trieu, Kristy Swiderski, Ashleigh M Philp, Andrew Philp, Matthew J Watt, David A Stroud, Rene Koopman, Gregory R Steinberg, Gordon S Lynch

Journal article  |  2021  |  Molecular Metabolism

OBJECTIVES: Preferential damage to fast, glycolytic myofibers is common in many muscle-wasting diseases, including Duchenne muscul..

Adipose Tissue Inflammation Is Directly Linked to Obesity-Induced Insulin Resistance, while Gut Dysbiosis and Mitochondrial Dysfunction Are Not Required

Heather L Petrick, Kevin P Foley, Soumaya Zlitni, Henver S Brunetta, Sabina Paglialunga, Paula M Miotto, Valerie Politis-Barber, Conor O’Dwyer, Diana J Philbrick, Morgan D Fullerton, Jonathan D Schertzer, Graham P Holloway

Journal article  |  2020  |  Function

Obesity is associated with adipose tissue hypertrophy, systemic inflammation, mitochondrial dysfunction, and intestinal dysbiosis...

Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport.

Paula M Miotto, Heather L Petrick, Graham P Holloway

Journal article  |  2020  |  AJP Endocrinology and Metabolism

Type 1 and type 2 diabetes are both tightly associated with impaired glucose control. Although both pathologies stem from differen..

Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2 O2 emission.

Marlou L Dirks, Paula M Miotto, Gijs H Goossens, Joan M Senden, Heather L Petrick, Janneau van Kranenburg, Luc JC van Loon, Graham P Holloway

Journal article  |  2020  |  The Journal of Physiology

KEY POINTS: We determined if bed rest increased mitochondrially derived reactive oxygen species and cellular redox stress, contrib..

The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance

Matthew J Watt, Paula M Miotto, William De Nardo, Magdalene K Montgomery

Journal article  |  2019  |  Endocrine Reviews

The liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic gluco..

Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women.

Paula M Miotto, Chris McGlory, Ravninder Bahniwal, Michael Kamal, Stuart M Phillips, Graham P Holloway

Journal article  |  2019  |  The FASEB Journal

Omega-3 (ω-3) supplementation attenuates immobilization-induced atrophy; however, the underlying mechanisms remain unclear. Since ..

Exercise-induced reductions in mitochondrial ADP sensitivity contribute to the induction of gene expression and mitochondrial biogenesis through enhanced mitochondrial H2O2 emission.

Paula M Miotto, Graham P Holloway

Journal article  |  2019  |  Mitochondrion

Acute exercise rapidly induces mitochondrial gene expression, however, the intracellular events regulating this process remain inc..

Role of mitochondria in the skeletal muscle metabolism in obesity and type 2 diabetes

PM Miotto, GP Holloway

Book Chapter  |  2019

High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity.

Paula M Miotto, Paul J LeBlanc, Graham P Holloway

Journal article  |  2018  |  Diabetes

Although molecular approaches altering mitochondrial content have implied a direct relationship between mitochondrial bioenergetic..

The importance of exercise intensity, volume and metabolic signalling events in the induction of mitochondrial biogenesis.

Heather L Petrick, Kaitlyn MJH Dennis, Paula M Miotto

Journal article  |  2018  |  The Journal of Physiology