David Chisanga

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy

Ashleigh R Poh, Christopher G Love, David Chisanga, James H Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G Ellies, Christophe Macri, Justine D Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L Chand, Clifford A Lowell, et al.

Journal article  |  2022  |  SCIENCE ADVANCES

Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be la..

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Susan N Christo, Maximilien Evrard, Simone L Park, Luke C Gandolfo, Thomas N Burn, Raissa Fonseca, Dane M Newman, Yannick O Alexandre, Nicholas Collins, Natasha M Zamudio, Fernando Souza-Fonseca-Guimaraes, Daniel G Pellicci, David Chisanga, Wei Shi, Laurent Bartholin, Gabrielle T Belz, Nicholas D Huntington, Andrew Lucas, Michaela Lucas, Scott N Mueller, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various org..

Transforming growth factor-b-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

Sarah S Gabriel, Carlson Tsui, David Chisanga, Flora Weber, Manuela Llano-Leon, Patrick M Gubser, Laurent Bartholin, Fernando Souza-Fonseca-Guimaraes, Nicholas D Huntington, Wei Shi, Daniel T Utzschneider, Axel Kallies

Journal article  |  2021  |  IMMUNITY

Antigen-specific CD8+ T cells in chronic viral infections and tumors functionally deteriorate, a process known as exhaustion. Exha..

Host IL11 Signaling Suppresses CD4( ) T cell-Mediated Antitumor Responses to Colon Cancer in Mice

Jennifer Huynh, David Baloyan, David Chisanga, Wei Shi, Megan O'Brien, Shoukat Afshar-Sterle, Mariah Alorro, Lokman Pang, David S Williams, Adam C Parslow, Pathum Thilakasiri, Moritz F Eissmann, Louis Boon, Frederick Masson, Ashwini L Chand, Matthias Ernst

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

IL11 is a member of the IL6 family of cytokines and signals through its cognate receptor subunits, IL11RA and glycoprotein 130 (GP..

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Monisha Samuel, Pamali Fonseka, Rahul Sanwlani, Lahiru Gangoda, Sing Ho Chee, Shivakumar Keerthikumar, Alex Spurling, Sai V Chitti, Damien Zanker, Ching-Seng Ang, Ishara Atukorala, Taeyoung Kang, Sanjay Shahi, Akbar L Marzan, Christina Nedeva, Claire Vennin, Morghan C Lucas, Lesley Cheng, David Herrmann, Mohashin Pathan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be ..

Early precursor T cells establish and propagate T cell exhaustion in chronic infection

Daniel T Utzschneider, Sarah S Gabriel, David Chisanga, Renee Gloury, Patrick M Gubser, Ajithkumar Vasanthakumar, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE IMMUNOLOGY

CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibi..

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar, David Chisanga, Jonas Blume, Renee Gloury, Kara Britt, Darren C Henstridge, Yifan Zhan, Santiago Valle Torres, Sebastian Liene, Nicholas Collins, Enyuan Cao, Tom Sidwell, Chaoran Li, Raul German Spallanzani, Yang Liao, Paul A Beavis, Thomas Gebhardt, Natalie Trevaskis, Stephen L Nutt, Jeffrey D Zajac, et al.

Journal article  |  2020  |  NATURE

Adipose tissue is an energy store and a dynamic endocrine organ1,2. In particular, visceral adipose tissue (VAT) is critical for t..

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Tom Sidwell, Yang Liao, Alexandra L Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K Smyth, Wei Shi, Axel Kallies

Journal article  |  2020  |  NATURE COMMUNICATIONS

Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; howe..

Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling.

Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang, Christopher G Adda, Lanzhou Jiang, Kuok Yap, Ivan K Poon, Peter Lock, Vincent Bulone, Marilyn Anderson, Suresh Mathivanan

Journal article  |  2019  |  Commun Biol

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting ..

Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling

Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang, Christopher G Adda, Lanzhou Jiang, Kuok Yap, Ivan K Poon, Peter Lock, Vincent Bulone, Marilyn Anderson, Suresh Mathivanan

Journal article  |  2019  |  COMMUNICATIONS BIOLOGY

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting ..