Jim Vadolas

Elevated levels of circulating monocytic myeloid derived suppressor cells in splenectomised β-thalassaemia/HbE patients.

Sirikwan Siriworadetkun, Rattanawan Thubthed, Chayada Thiengtavor, Kittiphong Paiboonsukwong, Archrob Khuhapinant, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2020  |  Br J Haematol

Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration.

Chayada Thiengtavor, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2020  |  Br J Haematol

Severe bacterial infection is a major complication causing morbidity and mortality in β-thalassaemia/HbE patients. Innate immunity..

SHRNA SCREEN FOR NOVEL EPIG ENETIC REGULATORS OF Gamma-GLOBIN SILENCING

Betty Kao, Bradley McColl, Shian Su, Matthew Ritchie, L Jamie Gearing, Miha Pakusch, Tracy Willson, Jovana Maksimovic, Alicia Oshlack, Marnie Blewitt, Jim Vadolas

Conference Proceedings  |  2018  |  JOURNAL OF GENE MEDICINE

Reduced PU.1 expression underlies aberrant neutrophil maturation and function in beta-thalassemia mice and patients

Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Garrett Zhen-Wei Ng, Philip Sutton, Nancy Wang, Isabelle Ooi, Chayada Thiengtavor, Suthat Fucharoen, Pornthip Chaichompoo, Saovaros Svasti, Odilia Wijburg, Jim Vadolas

Journal article  |  2017  |  BLOOD

β-Thalassemia is associated with several abnormalities of the innate immune system. Neutrophils in particular are defective, predi..

Epigenetic interplay at the beta-globin locus

Wei Shern Lee, Bradley McColl, Jovana Maksimovic, Jim Vadolas

Journal article  |  2017  |  BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS

During development, the α- and β-globin genes exhibit a highly conserved pattern of expression, giving rise to several development..

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

Sara E Howden, Bradley McColl, Astrid Glaser, Jim Vadolas, Steven Petrou, Melissa H Little, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2016  |  STEM CELL REPORTS

While Cas9 nucleases permit rapid and efficient generation of gene-edited cell lines, the CRISPR-Cas9 system can introduce undesir..

GFP to BFP Conversion: A Versatile Assay for the Quantification of CRISPR/Cas9-mediated Genome Editing

Astrid Glaser, Bradley McColl, Jim Vadolas

Journal article  |  2016  |  MOLECULAR THERAPY-NUCLEIC ACIDS

Hepcidin and 1,25(OH)2D3 effectively restore Ca2 transport in β-thalassemic mice: reciprocal phenomenon of Fe2 and Ca2 absorption.

Kamonshanok Kraidith, Saovaros Svasti, Jarinthorn Teerapornpuntakit, Jim Vadolas, Rattana Chaimana, Sarawut Lapmanee, Panan Suntornsaratoon, Nateetip Krishnamra, Suthat Fucharoen, Narattaphol Charoenphandhu

Journal article  |  2016  |  Am J Physiol Endocrinol Metab

Previously, β-thalassemia, an inherited anemic disorder with iron overload caused by loss-of-function mutation of β-globin gene, h..

Animal models of beta-hemoglobinopathies: utility and limitations

Bradley McColl, Jim Vadolas

Journal article  |  2016  |  JOURNAL OF BLOOD MEDICINE

The structural and functional conservation of hemoglobin throughout mammals has made the laboratory mouse an exceptionally useful ..

GFP to BFP Conversion: A Versatile Assay for the Quantification of CRISPR/Cas9-mediated Genome Editing.

Astrid Glaser, Bradley McColl, Jim Vadolas

Journal article  |  2016  |  Mol Ther Nucleic Acids