Jim Vadolas

A comprehensive study of immune function and immunophenotyping of white blood cells from β-thalassaemia/HbE patients on hydroxyurea supports the safety of the drug.

Sirikwan Siriworadetkun, Chayada Thiengtavor, Rattanawan Thubthed, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2023  |  Br J Haematol

Hydroxyurea (HU) (hydroxycarbamide) is used as a therapeutic option in β-thalassaemia to increase fetal haemoglobin, which results..

Increased autophagy leads to decreased apoptosis during β-thalassaemic mouse and patient erythropoiesis.

Pornthip Chaichompoo, Ramaneeya Nithipongvanitch, Wasinee Kheansaard, Alisa Tubsuwan, Kanitta Srinoun, Jim Vadolas, Suthat Fucharoen, Duncan R Smith, Pranee Winichagoon, Saovaros Svasti

Journal article  |  2022  |  Sci Rep

β-Thalassaemia results from defects in β-globin chain production, leading to ineffective erythropoiesis and subsequently to severe..

Impaired neutrophil extracellular trap formation in β-thalassaemia/HbE.

Rattanawan Thubthed, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2022  |  Sci Rep

Neutrophil dysfunction contributes to a high susceptibility to severe bacterial infection which is a leading cause of morbidity an..

Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering.

Mariella Obermeier, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert

Journal article  |  2022  |  Front Cell Dev Biol

Gene editing in male germline stem (GS) cells is a potent tool to study spermatogenesis and to create transgenic mice. Various eng..

Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia.

Tiwaporn Nualkaew, Karine Sii-Felice, Marie Giorgi, Bradley McColl, Julie Gouzil, Astrid Glaser, Hsiao PJ Voon, Hsin Y Tee, George Grigoriadis, Saovaros Svasti, Suthat Fucharoen, Suradej Hongeng, Philippe Leboulch, Emmanuel Payen, Jim Vadolas

Journal article  |  2021  |  Mol Ther

A primary challenge in lentiviral gene therapy of β-hemoglobinopathies is to maintain low vector copy numbers to avoid genotoxicit..

Correction: Targeted gene correction in the mdx mouse using short DNA fragments: towards application with bone marrow-derived cells for autologous remodeling of dystrophic muscle.

RM Kapsa, AF Quigley, J Vadolas, K Steeper, PA Ioannou, E Byrne, AJ Kornberg

Journal article  |  2021  |  Gene Ther

Figure 2 in the original manuscript contained two referential panels (B and C) that had been modified from a previous publication ..

SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of beta-thalassaemia

Jim Vadolas, Garrett Z Ng, Kai Kysenius, Peter J Crouch, Sibylle Dames, Mona Eisermann, Tiwaporn Nualkaew, Shahla Vilcassim, Ute Schaeper, George Grigoriadis

Journal article  |  2021  |  BRITISH JOURNAL OF HAEMATOLOGY

Beta-thalassaemia is an inherited blood disorder characterised by ineffective erythropoiesis and anaemia. Consequently, hepcidin e..

Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at Gγ-globin gene promoter.

Khanita Nuamsee, Thipphawan Chuprajob, Wachirachai Pabuprapap, Pornrutsami Jintaridth, Thongperm Munkongdee, Phatchariya Phannasil, Jim Vadolas, Pornthip Chaichompoo, Apichart Suksamrarn, Saovaros Svasti

Journal article  |  2021  |  Sci Rep

The reactivation of γ-globin chain synthesis to combine with excess free α-globin chains and form fetal hemoglobin (HbF) is an imp..

Elevated levels of circulating monocytic myeloid derived suppressor cells in splenectomised β-thalassaemia/HbE patients.

Sirikwan Siriworadetkun, Rattanawan Thubthed, Chayada Thiengtavor, Kittiphong Paiboonsukwong, Archrob Khuhapinant, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2020  |  Br J Haematol

Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration.

Chayada Thiengtavor, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas, Saovaros Svasti, Pornthip Chaichompoo

Journal article  |  2020  |  Br J Haematol

Severe bacterial infection is a major complication causing morbidity and mortality in β-thalassaemia/HbE patients. Innate immunity..