Robin Murray

Clinical predictors of antipsychotic treatment resistance: Development and internal validation of a prognostic prediction model by the STRATA-G consortium.

Sophie E Smart, Deborah Agbedjro, Antonio F Pardiñas, Olesya Ajnakina, Luis Alameda, Ole A Andreassen, Thomas RE Barnes, Domenico Berardi, Sara Camporesi, Martine Cleusix, Philippe Conus, Benedicto Crespo-Facorro, Giuseppe D'Andrea, Arsime Demjaha, Marta Di Forti, Kim Do, Gillian Doody, Chin B Eap, Aziz Ferchiou, Lorenzo Guidi, et al.

Journal article  |  2022  |  Schizophr Res

INTRODUCTION: Our aim was to, firstly, identify characteristics at first-episode of psychosis that are associated with later antip..

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy, Antonio F Pardinas, Ting Qi, Georgia Panagiotaropoulou, Swapnil Awasthi, Tim B Bigdeli, Julien Bryois, Chia-Yen Chen, Charlotte A Dennison, Lynsey S Hall, Max Lam, Kyoko Watanabe, Oleksandr Frei, Tian Ge, Janet C Harwood, Frank Koopmans, Sigurdur Magnusson, Alexander L Richards, Julia Sidorenko, Yang Wu, et al.

Journal article  |  2022  |  NATURE

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wid..

Genetic variants associated with longitudinal changes in brain structure across the lifespan

Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay, William S Kremen, Matthew S Panizzon, Loes M Olde Loohuis, Christopher D Whelan, Moji Aghajani, Clara Alloza, Dag Alanaes, Eric Artiges, Rosa Ayesa-Arriola, Gareth J Barker, et al.

Journal article  |  2022  |  NATURE NEUROSCIENCE

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of ..

Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

Antonio F Pardinas, Sophie E Smart, Isabella R Willcocks, Peter A Holmans, Charlotte A Dennison, Amy J Lynham, Sophie E Legge, Bernhard T Baune, Tim B Bigdeli, Murray J Cairns, Aiden Corvin, Ayman H Fanous, Josef Frank, Brian Kelly, Andrew McQuillin, Ingrid Melle, Preben B Mortensen, Bryan J Mowry, Carlos N Pato, Sathish Periyasamy, et al.

Journal article  |  2022  |  JAMA PSYCHIATRY

IMPORTANCE: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line ant..

Cortisol Levels in Childhood Associated With Emergence of Attenuated Psychotic Symptoms in Early Adulthood

Alexis E Cullen, Helen L Fisher, Nancy Gullet, Elizabeth R Fraser, Ruth E Roberts, Uzma Zahid, Melody To, Natalie Huijing Yap, Patricia A Zunszain, Carmine M Pariante, Stephen J Wood, Philip McGuire, Robin M Murray, Valeria Mondelli, Kristin R Laurens

Journal article  |  2021  |  BIOLOGICAL PSYCHIATRY

BACKGROUND: In individuals at clinical high-risk for psychosis, elevated cortisol levels predict subsequent onset of psychotic dis..

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Gabriella AM Blokland, Jakob Grove, Chia-Yen Chen, Chris Cotsapas, Stuart Tobet, Robert Handa, David St Clair, Todd Lencz, Bryan J Mowry, Sathish Periyasamy, Murray J Cairns, Paul A Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick F Sullivan, Aiden Corvin, Brien P Riley, Tonu Esko, Lili Milani, et al.

Journal article  |  2021  |  BIOLOGICAL PSYCHIATRY

BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar ..

A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts.

Guiyan Ni, Jian Zeng, Joana A Revez, Ying Wang, Zhili Zheng, Tian Ge, Restuadi Restuadi, Jacqueline Kiewa, Dale R Nyholt, Jonathan RI Coleman, Jordan W Smoller, undefined Schizophrenia Working Group of the Psychiatric Genomics Consortium, undefined Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Jian Yang, Peter M Visscher, Naomi R Wray

Journal article  |  2021  |  Biol Psychiatry

BACKGROUND: Polygenic scores (PGSs), which assess the genetic risk of individuals for a disease, are calculated as a weighted coun..

Cortisol Levels in Childhood Associated with Emergence of Attenuated Psychotic Symptoms in Early Adulthood

AE Cullen, HL Fisher, N Gullet, ER Fraser, RE Roberts, U Zahid, M To, N Yap, PA Zunszain, CM Pariante, SJ Wood, P McGuire, RM Murray, V Mondelli, KR Laurens

Journal article  |  2021  |  PSYCHONEUROENDOCRINOLOGY

Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder.

Jessica Mundy, Christopher Hübel, Joel Gelernter, Daniel Levey, Robin M Murray, Megan Skelton, Murray B Stein, undefined Million Veteran Program, Post Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium, Evangelos Vassos, Gerome Breen, Jonathan RI Coleman

Journal article  |  2021  |  Psychol Med

BACKGROUND: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are commonly reported co-occurring mental hea..

Classification of first-episode psychosis using cortical thickness: A large multicenter MRI study

A Pigoni, D Dwyer, L Squarcina, S Borgwardt, B Crespo-Facorro, P Dazzan, S Smesny, F Spaniel, G Spalletta, R Sanfelici, LA Antonucci, A Reuf, Oe F Oeztuerk, A Schmidt, S Ciufolini, F Schonborn-Harrisberger, K Langbein, A Gussew, JR Reichenbach, Y Zaytseva, et al.

Journal article  |  2021  |  EUROPEAN NEUROPSYCHOPHARMACOLOGY

Machine learning classifications of first-episode psychosis (FEP) using neuroimaging have predominantly analyzed brain volumes. So..