Uwe Ackermann

Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography

Catherine G Fitzgerald Dickmann, Alexander FF McDonald, Nhi Huynh, Angela Rigopoulos, Zhanqi Liu, Nancy Guo, Laura DD Osellame, Michael AA Gorman, Michael WW Parker, Hui KK Gan, Andrew MM Scott, Uwe Ackermann, Ingrid JG Burvenich, Jonathan MM White

Journal article  |  2023  |  CHEMICAL COMMUNICATIONS

Bromodomain and extraterminal (BET) proteins, a family of epigenetic regulators, have emerged as important oncology drug targets. ..

18F-labeling and initial in vivo evaluation of a Hitomi peptide for imaging tissue transglutaminase 2.

Uwe Ackermann, Luise Jäger, Angela Rigopoulos, Ingrid Julienne Georgette Burvenich, Graeme Joseph O'Keefe, Andrew M Scott

Journal article  |  2023  |  Nucl Med Biol

INTRODUCTION: Tissue transglutaminase 2 (TG2) is a calcium-dependent enzyme which cross-links proteins. It is overexpressed in man..

F-18 Site-Specific Labelling of a Single-Chain Antibody against Activated Platelets for the Detection of Acute Thrombosis in Positron Emission Tomography

Katie S Ardipradja, Christian W Wichmann, Kevin Hickson, Angela Rigopoulos, Karen M Alt, Hannah A Pearce, Xiaowei Wang, Graeme O'Keefe, Andrew M Scott, Karlheinz Peter, Christoph E Hagemeyer, Uwe Ackermann

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Positron emission tomography is the imaging modality of choice when it comes to the high sensitivity detection of key markers of t..

PET Imaging of brain muscarinic receptors with 18F-Fluorobenzyl-Dexetimide: A first in human study.

Christopher C Rowe, Natasha Krishnadas, Uwe Ackermann, Vincent Doré, Rachel YW Goh, Rodney Guzman, Lee Chong, Svetlana Bozinovski, Rachel Mulligan, Richard Kanaan, Brian Dean, Victor L Villemagne

Journal article  |  2021  |  Psychiatry Res Neuroimaging

M1 and M4 muscarinic receptor (mAChR) agonists are under development for the treatment of schizophrenia, Alzheimer's and Parkinson..

Development of [F-18]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease

Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J Hermans, David M Shackleford, Judith Field, Lian Xue, Andrea Aprico, Nancy C Hancock, Mohammad Haskali, Michael A Stashko, Stephen Frye, Xiaodong Wang, Michele D Binder, Uwe Ackermann, Michael W Parker, Trevor J Kilpatrick, Jonathan B Baell

Journal article  |  2021  |  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

MER tyrosine kinase (MERTK) upregulation is associated with M2 polarization of microglia, which plays a vital role in neuroregener..

PET Imaging of brain muscarinic receptors with F-18-Fluorobenzyl-Dexetimide: A first in human study

Christopher C Rowe, Natasha Krishnadas, Uwe Ackermann, Vincent Dore, Rachel YW Goh, Rodney Guzman, Lee Chong, Svetlana Bozinovski, Rachel Mulligan, Richard Kanaan, Brian Dean, Victor L Villemagne

Conference Proceedings  |  2021  |  PSYCHIATRY RESEARCH-NEUROIMAGING

M1 and M4 muscarinic receptor (mAChR) agonists are under development for the treatment of schizophrenia, Alzheimer's and Parkinson..

Radiolabelling and preclinical characterization of Zr-89-Df-radiolabelled bispecific anti-PD-L1/TGF-beta RII fusion protein bintrafusp alfa

Ingrid Julienne Georgette Burvenich, Yit Wooi Goh, Nancy Guo, Hui Kong Gan, Angela Rigopoulos, Diana Cao, Zhanqi Liu, Uwe Ackermann, Christian Werner Wichmann, Alexander Franklin McDonald, Nhi Huynh, Graeme Joseph O'Keefe, Sylvia Jie Gong, Fiona Elizabeth Scott, Linghui Li, Wanping Geng, Anup Zutshi, Yan Lan, Andrew Mark Scott

Journal article  |  2021  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PURPOSE: Τhis study aimed to optimize the 89Zr-radiolabelling of bintrafusp alfa investigational drug product and controls, and pe..

Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer.

Kim H Kwan, Ingrid JG Burvenich, Margaret M Centenera, Yit Wooi Goh, Angela Rigopoulos, Jonas Dehairs, Johannes V Swinnen, Ganesh V Raj, Andrew J Hoy, Lisa M Butler, Andrew M Scott, Jonathan M White, Uwe Ackermann

Journal article  |  2020  |  Nuclear Medicine and Biology

INTRODUCTION: Altered lipid metabolism and subsequent changes in cellular lipid composition have been observed in prostate cancer ..

Automated synthesis of F-18 radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry

Alexander F McDonald, Yit Wooi Goh, Jonathan M White, Andrew M Scott, Uwe Ackermann

Journal article  |  2020  |  EJNMMI RADIOPHARMACY AND CHEMISTRY

BACKGROUND: Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificit..

Automated radiosynthesis of [Ga-68]Ga-PSMA-11 and [Lu-177]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications

Christian W Wichmann, Uwe Ackermann, Stan Poniger, Kenneth Young, Benjamin Nguyen, Gordon Chan, John Sachinidis, Andrew M Scott

Journal article  |  2020  |  JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly chang..