Uwe Ackermann

Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer.

Kim H Kwan, Ingrid JG Burvenich, Margaret M Centenera, Yit Wooi Goh, Angela Rigopoulos, Jonas Dehairs, Johannes V Swinnen, Ganesh V Raj, Andrew J Hoy, Lisa M Butler, Andrew M Scott, Jonathan M White, Uwe Ackermann

Journal article  |  2020  |  Nuclear Medicine and Biology

INTRODUCTION: Altered lipid metabolism and subsequent changes in cellular lipid composition have been observed in prostate cancer ..

Automated synthesis of 18F radiolabelled indole containing Oncrasin-like molecules; a comparison of iodonium salts and boronic ester chemistry.

Alexander F McDonald, Yit Wooi Goh, Jonathan M White, Andrew M Scott, Uwe Ackermann

Journal article  |  2020  |  EJNMMI Radiopharmacy and Chemistry

BACKGROUND: Oncrasin-1 is a small molecule which was identified from a screen of KRAS mutant cancer cells and has shown specificit..

Automated radiosynthesis of [Ga-68]Ga-PSMA-11 and [Lu-177]Lu-PSMA-617 on the iPHASE MultiSyn module for clinical applications

Christian W Wichmann, Uwe Ackermann, Stan Poniger, Kenneth Young, Benjamin Nguyen, Gordon Chan, John Sachinidis, Andrew M Scott

Journal article  |  2020  |  Journal of Labelled Compounds and Radiopharmaceuticals

Prostate-specific membrane antigen (PSMA)-targeted imaging and therapy of prostate cancer using theranostic pairs is rapidly chang..

Human biodistribution and internal dosimetry of 4-[F-18]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors in the brain and heart

Cameron D Pain, Graeme J O'Keefe, Uwe Ackermann, Vincent Dore, Victor L Villemagne, Christopher C Rowe

Journal article  |  2020  |  EJNMMI Research

BACKGROUND: 4-[18F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype selective fluorine-18 labelled tracer for muscarinic ..

Imaging of neuroinflammation in adult Niemann-Pick type C disease A cross-sectional study

Mark Walterfang, Maria A Di Biase, Vanessa L Cropley, Andrew M Scott, Graeme O'Keefe, Dennis Velakoulis, Kunthi Pathmaraj, Uwe Ackermann, Christos Pantelis

Journal article  |  2020  |  Neurology

OBJECTIVE: To test the hypothesis that neuroinflammation is a key process in adult Niemann-Pick type C (NPC) disease, we undertook..

Three-step two-pot automated production of NCA [F-18]FDOPA with FlexLab module

Ya-Yao Huang, Stan Poniger, Chia-Ling Tsai, Henri J Tochon-Danguy, Uwe Ackermann, Ruoh-Fang Yen

Journal article  |  2020  |  Applied Radiation and Isotopes

Automated three-step two-pot production of no-carrier-added (NCA) [18F]FDOPA was first implemented in the iPHASE FlexLab module. D..

Synthesis and validation of [18F]mBPET-1, a fluorine-18 labelled mTOR inhibitor derivative based on a benzofuran backbone.

Christian W Wichmann, Yit Wooi Goh, Adam C Parslow, Angela Rigopoulos, Nancy Guo, Andrew M Scott, Uwe Ackermann, Jonathan M White

Journal article  |  2020  |  EJNMMI Radiopharmacy and Chemistry

BACKGROUND: Targeted therapy of HER2 positive breast cancer has led to clinical success in some cases with primary and secondary r..

PRELIMINARY FINDINGS OF A PHASE I SAFETY AND BIOIMAGING TRIAL OF KB004 (IFABOTUZUMAB) IN PATIENTS WITH GLIOBLASTOMA

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan Day, Andrew Boyd, Paul Thomas, Cameron Durrant, Andrew Scott

Conference Proceedings  |  2019  |  NEURO-ONCOLOGY

Investigation of automated radiofluorination methods for oxidatively sensitive aryl systems

A McDonald, YW Goh, JM White, A Scott, U Ackermann

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preliminary findings of a Phase I safety and bioimaging trial of KB004 (ifabotuzumab) in patients with glioblastoma

Hui Gan, Lawrence Cher, Po Inglis, Zarnie Lwin, Eddie Lau, Christian Wichmann, Uwe Ackermann, Nicole Coombs, Kirsten Remen, Nancy Guo, Sze Ting Lee, Sylvia Gong, Jodie B Palmer, Kunthi Pathmaraj, Graeme O'Keefe, Fiona Scott, Bryan W Day, Andrew W Boyd, Paul Thomas, Cameron Durrant, et al.

Conference Proceedings  |  2019  |  Clinical Trials