Bliss Cunningham

Host-Mediated Copper Stress Is Not Protective against Streptococcus pneumoniae D39 Infection

Stephanie L Neville, Bliss A Cunningham, Eve A Maunders, Aimee Tan, Jacinta A Watts, Katherine Ganio, Bart A Eijkelkamp, Victoria G Pederick, Raquel Gonzalez de Vega, David Clases, Philip A Doble, Christopher A McDevitt

Journal article  |  2022  |  MICROBIOLOGY SPECTRUM

Metal ions are required by all organisms for the chemical processes that support life. However, in excess they can also exert toxi..

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Erin B Brazel, Aimee Tan, Stephanie L Neville, Amy R Iverson, Saumya R Udagedara, Bliss A Cunningham, Mwilye Sikanyika, David MP De Oliveira, Bernhard Keller, Lisa Bohlmann, Ibrahim M El-Deeb, Katherine Ganio, Bart A Eijkelkamp, Alastair G McEwan, Mark von Itzstein, Megan J Maher, Mark J Walker, Jason W Rosch, Christopher A McDevitt

Journal article  |  2022  |  CELL REPORTS

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multidrug-res..

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Yogitha N Srikhanta, Melanie L Hutton, Milena M Awad, Nyssa Drinkwater, Julie Singleton, Sophie L Day, Bliss A Cunningham, Sheena McGowan, Dena Lyras

Journal article  |  2019  |  NATURE MICROBIOLOGY

Spore-forming bacteria encompass a diverse range of genera and species, including important human and animal pathogens, and food c..

Dietary zinc and the control of Streptococcus pneumoniae infection

Bart A Eijkelkamp, Jacqueline R Morey, Stephanie L Neville, Aimee Tan, Victoria G Pederick, Nerida Cole, Prashina P Singh, Cheryl-Lynn Y Ong, Raquel Gonzalez de Vega, David Clases, Bliss A Cunningham, Catherine E Hughes, Iain Comerford, Erin B Brazel, Jonathan J Whittall, Charles D Plumptre, Shaun R McColl, James C Paton, Alastair G McEwan, Philip A Doble, et al.

Journal article  |  2019  |  PLOS PATHOGENS

Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impa..

Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative

Melanie L Hutton, Bliss A Cunningham, Kate E Mackin, Shelley A Lyon, Meagan L James, Julian I Rood, Dena Lyras

Journal article  |  2017  |  SCIENTIFIC REPORTS

The increased incidence of antibiotic resistant 'superbugs' has amplified the use of broad spectrum antibiotics worldwide. An unin..

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections

Glen P Carter, Anjana Chakravorty, Anh Pham Nguyen Tu, Steven Mileto, Fernanda Schreiber, Lucy Li, Pauline Howarth, Simon Clare, Bliss Cunningham, Susan P Sambol, Adam Cheknis, Iris Figueroa, Stuart Johnson, Dale Gerding, Julian I Rood, Gordon Dougan, Trevor D Lawley, Dena Lyras

Journal article  |  2015  |  MBIO

UNLABELLED: Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal pathogen, and a world..