Maria Nogueira De Menezes

Harnessing liver-resident memory T cells for protection against malaria

Daniel Fernandez-Ruiz, Maria N de Menezes, Lauren E Holz, Sonia Ghilas, William R Heath, Lynette Beattie

Journal article  |  2021  |  Expert Review of Vaccines

INTRODUCTION: Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in pe..

A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver T-RM Cell-Mediated Immunity against Malaria in Mice

Ana Maria Valencia-Hernandez, Wei Yi Ng, Nazanin Ghazanfari, Sonia Ghilas, Maria N de Menezes, Lauren E Holz, Cheng Huang, Kieran English, Myo Naung, Peck Szee Tan, Kirsteen M Tullett, Thiago M Steiner, Matthias H Enders, Lynette Beattie, Yu Cheng Chua, Claerwen M Jones, Anton Cozijnsen, Vanessa Mollard, Yeping Cai, David G Bowen, et al.

Journal article  |  2020  |  Cell Host & Microbe

Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter..

Glycolipid-peptide vaccination induces liver-resident memory CD8( ) T cells that protect against rodent malaria

Lauren E Holz, Yu Cheng Chua, Maria N de Menezes, Regan J Anderson, Sarah L Draper, Benjamin J Compton, Susanna TS Chan, Juby Mathew, Jasmine Li, Lukasz Kedzierski, Zhongfang Wang, Lynette Beattie, Matthias H Enders, Sonia Ghilas, Rose May, Thiago M Steiner, Joshua Lange, Daniel Fernandez-Ruiz, Ana Maria Valencia-Hernandez, Taryn L Osmond, et al.

Journal article  |  2020  |  Science Immunology

Liver resident-memory CD8+ T cells (TRM cells) can kill liver-stage Plasmodium-infected cells and prevent malaria, but simple vacc..

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria.

Maria Nogueira de Menezes, Érika Machado Salles, Flávia Vieira, Eduardo Pinheiro Amaral, Vanessa Zuzarte-Luís, Alexandra Cassado, Sabrina Epiphanio, José Maria Alvarez, José Carlos Alves-Filho, Maria Manuel Mota, Maria Regina D'Império-Lima

Journal article  |  2019  |  Scientific Reports

Malaria causes hepatic inflammation and damage, which contribute to disease severity. The pro-inflammatory cytokine interleukin (I..

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria

Erika Machado de Salles, Maria Nogueira de Menezes, Renan Siqueira, Henrique Borges da Silva, Eduardo Pinheiro Amaral, Sheyla Ines Castillo-Mendez, Isabela Cunha, Alexandra dos Anjos Cassado, Flavia Sarmento Vieira, David Nicholas Olivieri, Carlos Eduardo Tadokoro, Jose Maria Alvarez, Robson Coutinho-Silva, Maria Regina D'Imperio-Lima

Journal article  |  2017  |  PLoS Pathogens

A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strateg..

Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent

Diogo RM Moreira, Matheus S de Sa, Tais S Macedo, Maria N Menezes, Jose Rui M Reys, Antonio EG Santana, Thaissa L Silva, Gabriela LA Maia, Jose M Barbosa-Filho, Celso A Camara, Tania MS da Silva, Katia N da Silva, Elisalva T Guimaraes, Ricardo R dos Santos, Marilia OF Goulart, Milena BP Soares

Journal article  |  2015  |  Journal of Enzyme Inhibition and Medicinal Chemistry

This study reports on the design, synthesis and antiparasitic activity of three new semi-synthetic naphthoquinones structurally re..

In Vivo Approaches Reveal a Key Role for DCs in CD4 T Cell Activation and Parasite Clearance during the Acute Phase of Experimental Blood-Stage Malaria

Henrique Borges da Silva, Raissa Fonseca, Alexandra dos Anjos Cassado, Erika Machado de Salles, Maria Nogueira de Menezes, Jean Langhorne, Katia Regina Perez, Iolanda Midea Cuccovia, Bernhard Ryffel, Vasco M Barreto, Claudio Romero Farias Marinho, Silvia Beatriz Boscardin, Jose Maria Alvarez, Maria Regina D'Imperio-Lima, Carlos Eduardo Tadokoro

Journal article  |  2015  |  PLoS Pathogens

Antimalarial Activity of Physalins B, D, F, and G

Matheus S Sa, Maria N de Menezes, Antoniana U Krettli, Ivone M Ribeiro, Therezinha CB Tomassini, Ricardo Ribeiro dos Santos, Walter F de Azevedo, Milena BP Soares

Journal article  |  2011  |  Journal of Natural Products

The antimalarial activities of physalins B, D, F, and G (1-4), isolated from Physalis angulata, were investigated. In silico analy..