Brooke Farrugia

Arthritis and Duchenne muscular dystrophy: the role of chondroitin sulfate and its associated proteoglycans in disease pathology and as a diagnostic marker.

Marissa L Maciej-Hulme, James Melrose, Brooke L Farrugia

Journal article  |  2023  |  Am J Physiol Cell Physiol

Chondroitin sulfate (CS) is a ubiquitous glycosaminoglycan covalently attached to the core proteins of cell surface, extracellular..

Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration.

Anthony J Hayes, Brooke L Farrugia, Ifechukwude J Biose, Gregory J Bix, James Melrose

Journal article  |  2022  |  Front Cell Dev Biol

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential roles in repair biology. Perlecan is u..

A review of simulation training and new 3D computer-generated synthetic organs for robotic surgery education

Daniel M Costello, Isabel Huntington, Grace Burke, Brooke Farrugia, Andrea J O'Connor, Anthony J Costello, Benjamin C Thomas, Philip Dundee, Ahmed Ghazi, Niall Corcoran

Journal article  |  2021  |  JOURNAL OF ROBOTIC SURGERY

We conducted a comprehensive review of surgical simulation models used in robotic surgery education. We present an assessment of t..

Effect of Recombinant Human Perlecan Domain V Tethering Method on Protein Orientation and Blood Contacting Activity on Polyvinyl Chloride

Keerthana Chandrasekar, Brooke L Farrugia, Lacey Johnson, Denese Marks, David Irving, Zehra Elgundi, Kieran Lau, Ha Na Kim, Jelena Rnjak-Kovacina, Marcela M Bilek, John M Whitelock, Megan S Lord

Journal article  |  2021  |  ADVANCED HEALTHCARE MATERIALS

Surface modification of biomaterials is a promising approach to control biofunctionality while retaining the bulk biomaterial prop..

Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to In Vivo Compatibility in a Murine Subdermal Implant Model

Tim R Dargaville, Damien G Harkin, Jong-Ryul Park, Amanda Cavalcanti, Eleonore CL Bolle, Flavia Medeiros Savi, Brooke L Farrugia, Bryn D Monnery, Yann Bernhard, Joachim FR Van Guyse, Annelore Podevyn, Richard Hoogenboom

Journal article  |  2021  |  BIOMACROMOLECULES

A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are..

Macromolecular Interactions in Cartilage Extracellular Matrix Vary According to the Cartilage Type and Location

Manula SB Rathnayake, Brooke L Farrugia, Karyna Kulakova, Colet EM ter Voert, Gerjo JVM van Osch, Kathryn S Stok

Journal article  |  2021  |  CARTILAGE

OBJECTIVE: To investigate GAG-ECM (glycosaminoglycan-extracellular matrix) interactions in different cartilage types. To achieve t..

Use of Chondroitin Sulphate to Aid In Vitro Stem Cell Differentiation

Brooke Farrugia, Anthony J Hayes, James Melrose

Book Chapter  |  2021

Spatiotemporal Expression of 3-B-3(-) and 7-D-4 Chondroitin Sulfation, Tissue Remodeling, and Attempted Repair in an Ovine Model of Intervertebral Disc Degeneration.

Brooke Farrugia, Susan M Smith, Cindy C Shu, James Melrose

Journal article  |  2020  |  Cartilage

OBJECTIVE: Examination of intervertebral disc (IVD) regeneration in an ovine annular lesion model. HYPOTHESIS: Sulfation motifs ar..

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Z Elgundi, M Papanicolaou, G Major, TR Cox, J Melrose, JM Whitelock, BL Farrugia

Journal article  |  2020  |  Frontiers in Oncology

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process i..

Enhanced osteogenic differentiation of human fetal cartilage rudiment cells on graphene oxide-PLGA hybrid microparticles

SC Thickett, E Hamilton, G Yogeswaran, PB Zetterlund, BL Farrugia, MS Lord

Journal article  |  2019  |  Journal of Functional Biomaterials

Poly(d,l–lactide–co–glycolide) (PLGA) has been extensively explored for bone regeneration applications; however, its clinical use ..