Benjamin Hogan

Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome.

Philip M Boone, Scott Paterson, Kiana Mohajeri, Wenmiao Zhu, Casie A Genetti, Derek JC Tai, Neeharika Nori, Pankaj B Agrawal, Carlos A Bacino, Weimin Bi, Michael E Talkowski, Benjamin M Hogan, Lance H Rodan

Journal article  |  2020  |  American Journal of Medical Genetics Part A

Hennekam lymphangiectasia-lymphedema syndrome is an autosomal recessive disorder characterized by congenital lymphedema, intestina..

Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context

Celine J Vivien, Cathy Pichol-Thievend, Choon Boon Sim, Jacob B Smith, Neil Bower, Benjamin M Hogan, James E Hudson, Mathias Francois, Enzo R Porrello

Journal article  |  2019  |  npj Regenerative Medicine

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen

Journal article  |  2019  |  Cell Reports

Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors

Tiffany CY Eng, Wenxuan Chen, Kazuhide S Okuda, June P Misa, Yvonne Padberg, Kathryn E Crosier, Philip S Crosier, Christopher J Hall, Stefan Schulte-Merker, Benjamin M Hogan, Jonathan W Astin

Journal article  |  2019  |  EMBO reports

Lymphatic vessels are known to be derived from veins; however, recent lineage-tracing experiments propose that specific lymphatic ..

Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

Lin Grimm, Hiroyuki Nakajima, Smrita Chaudhury, Neil Bower, Kazuhide S Okuda, Andrew G Cox, Natasha L Harvey, Katarzyna Koltowska, Naoki Mochizuki, Benjamin M Hogan

Journal article  |  2019  |  eLife

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Sungmin Baek, Tae Gyu Oh, Genevieve Secker, Drew L Sutton, Kazuhide S Okuda, Scott Paterson, Neil I Bower, John Toubia, Katarzyna Koltowska, Samuel J Capon, Gregory J Baillie, Cas Simons, George EO Muscat, Anne K Lagendijk, Kelly A Smith, Natasha L Harvey, Benjamin M Hogan

Journal article  |  2019  |  Developmental Cell

The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The..

Myosin Vb is required for correct trafficking of N-cadherin and cardiac chamber ballooning

Daniela R Grassini, Jason da Silva, Thomas E Hall, Gregory J Baillie, Cas Simons, Robert G Parton, Benjamin M Hogan, Kelly A Smith

Journal article  |  2019  |  Developmental Dynamics

Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling

Koji Ando, Weili Wang, Di Peng, Ayano Chiba, Anne K Lagendijk, Lindsey Barske, J Gage Crump, Didier YR Stainier, Urban Lendahl, Katarzyna Koltowska, Benjamin M Hogan, Shigetomo Fukuhara, Naoki Mochizuki, Christer Betsholtz

Journal article  |  2019  |  Development

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction

Ilkka Paatero, Loic Sauteur, Minkyoung Lee, Anne K Lagendijk, Daniel Heutschi, Cora Wiesner, Camilo Guzman, Dimitri Bieli, Benjamin M Hogan, Markus Affolter, Heinz-Georg Belting

Journal article  |  2018  |  Nature Communications

Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume

Daniela R Grassini, Anne K Lagendijk, Jessica E De Angelis, Jason Da Silva, Angela Jeanes, Nicole Zettler, Neil I Bower, Benjamin M Hogan, Kelly A Smith

Journal article  |  2018  |  Development

A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development

Cathy Pichol-Thievend, Kelly L Betterman, Xiaolei Liu, Wanshu Ma, Renae Skoczylas, Emmanuelle Lesieur, Frank L Bos, Dorte Schulte, Stefan Schulte-Merker, Benjamin M Hogan, Guillermo Oliver, Natasha L Harvey, Mathias Francois

Journal article  |  2018  |  Development

Brain drains: new insights into brain clearance pathways from lymphatic biology

Neil I Bower, Benjamin M Hogan

Journal article  |  2018  |  Journal of Molecular Medicine

Notching a New Pathway in Vascular Flow Sensing

Anne K Lagendijk, Alpha S Yap, Benjamin M Hogan

Journal article  |  2018  |  Trends in Cell Biology

Visualization and Tools for Analysis of Zebrafish Lymphatic Development

Kazuhide S Okuda, Sungmin Baek, Benjamin M Hogan

Book Chapter  |  2018  |  Methods in Molecular Biology

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

Anne Karine Lagendijk, Guillermo A Gomez, Sungmin Baek, Daniel Hesselson, William E Hughes, Scott Paterson, Daniel E Conway, Heinz-Georg Belting, Markus Affolter, Kelly A Smith, Martin A Schwartz, Alpha S Yap, Benjamin M Hogan

Journal article  |  2017  |  Nature Communications

Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin/F-actin based oscillatory ratchet mechanism

Ilkka Paatero, Loïc Sauteur, Minkyoung Lee, Anne Lagendijk, Daniel Heutschi, Dimitri Bieli, Benjamin Hogan, Markus Affolter, Heinz-Georg Belting

Journal article  |  2017

Abstract Angiogenesis and vascular remodeling are driven by a wide range of endothelial cell behaviors, such as cell divisions, ce..

Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling

Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.

Journal article  |  2017  |  Science Signaling

How to Plumb a Pisces: Understanding Vascular Development and Disease Using Zebrafish Embryos

Benjamin M Hogan, Stefan Schulte-Merker

Journal article  |  2017  |  Developmental Cell

SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development

Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens, Emmanuelle Lesieur, Ke Liu, Indrika Ratnayaka, Monica Corada, George Bou-Gharios, Jason Carroll, Elisabetta Dejana, Stefan Schulte-Merker, Benjamin Hogan, Monica Beltrame, et al.

Journal article  |  2017  |  Development

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

Neil I Bower, Katarzyna Koltowska, Cathy Pichol-Thievend, Isaac Virshup, Scott Paterson, Anne K Lagendijk, Weili Wang, Benjamin W Lindsey, Stephen J Bent, Sungmin Baek, Maria Rondon-Galeano, Daniel G Hurley, Naoki Mochizuki, Cas Simons, Mathias Francois, Christine A Wells, Jan Kaslin, Benjamin M Hogan

Journal article  |  2017  |  Nature Neuroscience

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development

Neil I Bower, Adam J Vogrin, Ludovic Le Guen, Huijun Chen, Steven A Stacker, Marc G Achen, Benjamin M Hogan

Journal article  |  2017  |  Development

Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice

Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril AB Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, et al.

Journal article  |  2017  |  eLife

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover

Jessica E De Angelis, Anne K Lagendijk, Huijun Chen, Alisha Tromp, Neil I Bower, Kathryn A Tunny, Andrew J Brooks, Jeroen Bakkers, Mathias Francois, Alpha S Yap, Gas Simons, Carol Wicking, Benjamin M Hogan, Kelly A Smith

Journal article  |  2017  |  Developmental Cell

Utilising polymorphisms to achieve allele-specific genome editing in zebrafish

Samuel J Capon, Gregory J Baillie, Neil I Bower, Jason A da Silva, Scott Paterson, Benjamin M Hogan, Cas Simons, Kelly A Smith

Journal article  |  2017  |  Biology Open

Expanding the genotypic spectrum of CCBE1 mutations in Hennekam syndrome

Joanna Crawford, Neil I Bower, Benjamin M Hogan, Ryan J Taft, Michael T Gabbett, Julie McGaughran, Cas Simons

Journal article  |  2016  |  American Journal of Medical Genetics Part A

Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein

Andrew L Koenig, Kristina Baltrunaite, Neil I Bower, Andrea Rossi, Didier YR Stainier, Benjamin M Hogan, Saulius Sumanas

Journal article  |  2016  |  Developmental Biology

Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish

Katarzyna Koltowska, Anne Karine Lagendijk, Cathy Pichol-Thievend, Johanna C Fischer, Mathias Francois, Elke A Ober, Alpha S Yap, Benjamin M Hogan

Journal article  |  2015  |  Cell Reports

mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish

Katarzyna Koltowska, Scott Paterson, Neil I Bower, Gregory J Baillie, Anne K Lagendijk, Jonathan W Astin, Huijun Chen, Mathias Francois, Philip S Crosier, Ryan J Taft, Cas Simons, Kelly A Smith, Benjamin M Hogan

Journal article  |  2015  |  Genes & Development

DEVELOPMENTAL BIOLOGY Diversity in the lymphatic vasculature

Benjamin M Hogan, Brian L Black

Journal article  |  2015  |  Nature

Cep55 regulates embryonic growth and development by promoting Akt stability in zebrafish

Jessie Jeffery, Christine Neyt, Wade Moore, Scott Paterson, Neil I Bower, Georgia Chenevix-Trench, Heather Verkade, Benjamin M Hogan, Kum Kum Khanna

Journal article  |  2015  |  The FASEB Journal

Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer

Selwin K Wu, Anne K Lagendijk, Benjamin M Hogan, Guillermo A Gomez, Alpha S Yap

Journal article  |  2015  |  Cell Cycle

VE-cadherin in Vascular Development: A Coordinator of Cell Signaling and Tissue Morphogenesis

Anne Karine Lagendijk, Benjamin M Hogan

Book Chapter  |  2015  |  Current Topics in Developmental Biology

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) Regulates Notch Signaling and Vascular Development in Zebrafish

Baptiste Coxam, Christine Neyt, Daniela R Grassini, Ludovic Le Guen, Kelly A Smith, Stefan Schulte-Merker, Benjamin M Hogan

Journal article  |  2015  |  Developmental Dynamics

Lymphatic vascular specification and its modulation during embryonic development

Cathy Pichol-Thievend, Benjamin M Hogan, Mathias Francois

Journal article  |  2014  |  Microvascular Research

Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting

Jonathan W Astin, Michael JL Haggerty, Kazuhide S Okuda, Ludovic Le Guen, June P Misa, Alisha Tromp, Benjamin M Hogan, Kathryn E Crosier, Philip S Crosier

Journal article  |  2014  |  Development

Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development

Baptiste Coxam, Amelie Sabine, Neil I Bower, Kelly A Smith, Cathy Pichol-Thievend, Renae Skoczylas, Jonathan W Astin, Emmanuelle Frampton, Muriel Jaquet, Philip S Crosier, Robert G Parton, Natasha L Harvey, Tatiana V Petrova, Stefan Schulte-Merker, Mathias Francois, Benjamin M Hogan

Journal article  |  2014  |  Cell Reports

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis

Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan

Journal article  |  2014  |  Development

Endothelial cell-cell adhesion during zebrafish vascular development

Anne Karine Lagendijk, Alpha S Yap, Benjamin M Hogan

Journal article  |  2014  |  Cell Adhesion & Migration

Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development

Joelle Kartopawiro, Neil I Bower, Tara Karnezis, Jan Kazenwadel, Kelly L Betterman, Emmanuelle Lesieur, Katarzyna Koltowska, Jonathan Astin, Philip Crosier, Sonja Vermeren, Marc G Achen, Steven A Stacker, Kelly A Smith, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

Journal article  |  2014  |  Human Molecular Genetics

VEGFD regulates blood vascular development by modulating SOX18 activity

Tam Duong, Katarzyna Koltowska, Cathy Pichol-Thievend, Ludovic Le Guen, Frank Fontaine, Kelly A Smith, Truong Vy, Renae Skoczylas, Steven A Stacker, Marc G Achen, Peter Koopman, Benjamin M Hogan, Mathias Francois

Journal article  |  2014  |  Blood

ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.

Garry HK Chang, Angelina J Lay, Ka Ka Ting, Yang Zhao, Paul R Coleman, Elizabeth E Powter, Ann Formaz-Preston, Christopher J Jolly, Neil I Bower, Benjamin M Hogan, Silke Rinkwitz, Thomas S Becker, Mathew A Vadas, Jennifer R Gamble

Journal article  |  2014  |  Small GTPases

The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbatio..

In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation

Maria-Cristina Keightley, Meredith O Crowhurst, Judith E Layton, Traude Beilharz, Sebastian Markmiller, Sony Varma, Benjamin M Hogan, Tanya A de Jong-Curtain, Joan K Heath, Graham J Lieschke

Journal article  |  2013  |  FEBS Letters

Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish

Solei Cermenati, Silvia Moleri, Christine Neyt, Erica Bresciani, Silvia Carra, Daniela R Grassini, Alice Omini, Michela Goi, Franco Cotelli, Mathias Francois, Benjamin M Hogan, Monica Beltrame

Journal article  |  2013  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Getting out and about: the emergence and morphogenesis of the vertebrate lymphatic vasculature

Katarzyna Koltowska, Kelly L Betterman, Natasha L Harvey, Benjamin M Hogan

Journal article  |  2013  |  Development

The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling

Maria L Macheda, Willy W Sun, Kumudhini Kugathasan, Benjamin M Hogan, Neil I Bower, Michael M Halford, You Fang Zhang, Bonnie E Jacques, Graham J Lieschke, Alain Dabdoub, Steven A Stacker

Journal article  |  2012  |  Journal of Biological Chemistry

Zebrafish prox1b Mutants Develop a Lymphatic Vasculature, and prox1b Does Not Specifically Mark Lymphatic Endothelial Cells

Shijie Tao, Merlijn Witte, Robert J Bryson-Richardson, Peter D Currie, Benjamin M Hogan, Stefan Schulte-Merker

Journal article  |  2011  |  PLoS ONE

Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development

Kelly A Smith, Anne K Lagendijk, Andrew D Courtney, Huijun Chen, Scott Paterson, Benjamin M Hogan, Carol Wicking, Jeroen Bakkers

Journal article  |  2011  |  Development

The Transcriptional Control of Lymphatic Vascular Development

Mathias Francois, Natasha L Harvey, Benjamin M Hogan

Journal article  |  2011  |  Physiology

Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish

Ilse Geudens, Robert Herpers, Karlien Hermans, Inmaculada Segura, Carmen Ruiz de Almodovar, Jeroen Bussmann, Frederik De Smet, Wouter Vandevelde, Benjamin M Hogan, Arndt Siekmann, Filip Claes, John C Moore, Anna Silvia Pistocchi, Sonja Loges, Massimiliano Mazzone, Giovanni Mariggi, Francoise Bruyere, Franco Cotelli, Dontscho Kerjaschki, Agnes Noel, et al.

Journal article  |  2010  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans

Marielle Alders, Benjamin M Hogan, Evisa Gjini, Faranak Salehi, Lihadh Al-Gazali, Eric A Hennekam, Eva E Holmberg, Marcel MAM Mannens, Margot F Mulder, G Johan A Offerhaus, Trine E Prescott, Eelco J Schroor, Joke BGM Verheij, Merlijn Witte, Petra J Zwijnenburg, Mikka Vikkula, Stefan Schulte-Merker, Raoul C Hennekam

Journal article  |  2009  |  Nature Genetics

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries

Benjamin M Hogan, Robert Herpers, Merlijn Witte, Hanna Helotera, Kari Alitalo, Henricus J Duckers, Stefan Schulte-Merker

Journal article  |  2009  |  Development

Functional Analyses of Human and Zebrafish 18-Amino Acid In-Frame Deletion Pave the Way for Domain Mapping of the Cerebral Cavernous Malformation 3 Protein

Katrin Voss, Sonja Stahl, Benjamin M Hogan, Joerg Reinders, Elisa Schleider, Stefan Schulte-Merker, Ute Felbor

Journal article  |  2009  |  Human Mutation

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

Benjamin M Hogan, Frank L Bos, Jeroen Bussmann, Merlijn Witte, Neil C Chi, Henricus J Duckers, Stefan Schulte-Merker

Journal article  |  2009  |  Nature Genetics

NEW ANIMAL MODELS OF LYMPHANGIOGENESIS

Benjamin M Hogan, Stefan Schulte-Merker

Book Chapter  |  2009  |  Cancer Metastasis - Biology and Treatment

Simple and efficient transgenesis with meganuclease constructs in zebrafish.

Daniele Soroldoni, Benjamin M Hogan, Andrew C Oates

Journal article  |  2009  |  Methods in molecular biology (Clifton, N.J.)

In the past, microinjection of plasmid DNA into early embryos represented the state of the art to generate transgenic zebrafish. H..

ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish

Benjamin M Hogan, Jeroen Bussmann, Hartwig Wolburg, Stefan Schulte-Merker

Journal article  |  2008  |  Human Molecular Genetics

Manipulation of gene expression during zebrafish embryonic development using transient approaches.

Benjamin M Hogan, Heather Verkade, Graham J Lieschke, Joan K Heath

Other  |  2008  |  Methods Mol. Biol.

The rapid embryonic development and high fecundity of zebrafish contribute to the great advantages of this model for the study of ..

CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish

Sebastian Dworkin, Joan K Heath, Tanya A deJong-Curtain, Benjamin M Hogan, Graham J Lieschke, Jordane Malaterre, Robert G Ramsay, Theo Mantamadiotis

Journal article  |  2007  |  Developmental Biology

Characterisation of duplicate zinc finger like 2 erythroid precursor genes in zebrafish

Benjamin M Hogan, Luke Pase, Nathan E Hall, Graham J Lieschke

Journal article  |  2006  |  Development Genes and Evolution

Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafish

BM Hogan, JE Layton, UJ Pyati, SL Nutt, JW Hayman, S Varma, JK Heath, D Kimelman, GJ Lieschke

Journal article  |  2006  |  Current Biology

Localization of parathyroid hormone in developing zebrafish embryos.

BM Hogan, JA Danks, JE Layton, NE Hall, JK Heath, GJ Lieschke

Conference Proceedings  |  2006  |  JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY

Zebrafish forward genetics identifies a receptor essential for embryonic myelopoiesis

BM Hogan, JE Layton, GJ Lieschke

Conference Proceedings  |  2005  |  MECHANISMS OF DEVELOPMENT

Duplicate zebrafish PTH genes are expressed along the lateral line and in the central nervous system during embryogenesis

BM Hogan, JA Danks, JE Layton, NE Hall, JK Heath, GJ Lieschke

Conference Proceedings  |  2005  |  BONE

Duplicate zebrafish pth genes are expressed along the lateral line and in the central nervous system during embryogenesis

BM Hogan, JA Danks, JE Layton, NE Hall, JK Heath, GJ Lieschke

Journal article  |  2005  |  Endocrinology

Zebrafish gcm2 is required for gill filament budding from pharyngeal ectoderm

BM Hogan, MP Hunter, AC Oates, MO Crowhurst, NE Hall, JK Heath, VE Prince, GJ Lieschke

Journal article  |  2004  |  Developmental Biology

The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish

DJ Mawdsley, HM Cooper, BM Hogan, SH Cody, GJ Lieschke, JK Heath

Journal article  |  2004  |  Developmental Biology

Yan regulates Lozenge during Drosophila eye development

KJ Behan, CD Nichols, TL Cheung, A Farlow, BM Hogan, P Batterham, JA Pollock

Journal article  |  2002  |  Development Genes and Evolution