Benjamin Hogan

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function.

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil I Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  Nat Cell Biol

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

Kazuhide S Okuda, Mikaela Keyser, David B Gurevich, Caterina Sturtzel, Elizabeth A Mason, Scott Patterson, Huijun Chen, Mark Scott, Nicholas D Condon, Paul Martin, Martin Distel, Benjamin M Hogan

Journal article  |  2021  |  ELIFE

The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair, and disease. Angiogenesis is..

Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to apical extrusion

Kinga Duszyc, Guillermo A Gomez, Anne K Lagendijk, Mei-Kwan Yau, Bageshri Naimish Nanavati, Briony L Gliddon, Thomas E Hall, Suzie Verma, Benjamin M Hogan, Stuart M Pitson, David P Fairlie, Robert G Parton, Alpha S Yap

Journal article  |  2021  |  CURRENT BIOLOGY

Epithelia must eliminate apoptotic cells to preserve tissue barriers and prevent inflammation.1 Several different mechanisms exist..

The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm

Charlotte D Koopman, Jessica De Angelis, Swati P Iyer, Arie O Verkerk, Jason Da Silva, Geza Berecki, Angela Jeanes, Gregory J Baillie, Scott Paterson, Veronica Uribe, Ophelia Ehrlich, Samuel D Robinson, Laurence Garric, Steven Petrou, Cas Simons, Irina Vetter, Benjamin M Hogan, Teun P de Boer, Jeroen Bakkers, Kelly A Smith

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and surviv..

Lymphatics and the Brain It's Time to Go Fishing

Benjamin M Hogan, Neil I Bower

Journal article  |  2021  |  CIRCULATION RESEARCH

Network patterning, morphogenesis and growth in lymphatic vascular development.

Lin Grimm, Benjamin M Hogan

Book Chapter  |  2021  |  Current Topics in Developmental Biology

The lymphatic vasculature is a vital component of the vertebrate vascular system that mediates tissue fluid homeostasis, lipid upt..

3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

Kazuhide S Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S Crosier, Katarzyna Koltowska, Jonathan W Astin, Pei Jean Tan, Benjamin M Hogan, Vyomesh Patel

Journal article  |  2021  |  Pharmaceuticals

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, includin..

Deep conservation of the enhancer regulatory code in animals

Emily S Wong, Dawei Zheng, Siew Z Tan, Neil L Bower, Victoria Garside, Gilles Vanwalleghem, Federico Gaiti, Ethan Scott, Benjamin M Hogan, Kazu Kikuchi, Edwina McGlinn, Mathias Francois, Bernard M Degnan

Journal article  |  2020  |  SCIENCE

Interactions of transcription factors (TFs) with DNA regulatory sequences, known as enhancers, specify cell identity during animal..

Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.

Jessica L Teo, Vanesa M Tomatis, Luke Coburn, Anne K Lagendijk, Irin-Maya Schouwenaar, Srikanth Budnar, Thomas E Hall, Suzie Verma, Robert W McLachlan, Benjamin M Hogan, Robert G Parton, Alpha S Yap, Guillermo A Gomez

Journal article  |  2020  |  Mol Biol Cell

Epithelia can eliminate apoptotic cells by apical extrusion. This is a complex morphogenetic event where expulsion of the apoptoti..