Ben Hogan's research investigates the lymphatic vasculature and the blood brain barrier, which play important roles in cancer metastasis and vascular disease. His research team studies developmental processes using zebrafish and mouse embryos.
Work from his group has led to discovery and characterisation of a number of genes essential for angiogenesis and lymphangiogenesis. In particular, he investigates molecular mechanisms controlling the CCBE1/VEGFC/VEGFR3 signalling axis, uses large scale forward genetic screening and examines the cellular processes involved in vessel formation in live tissues. His group is located between the Petermac and the University of Melbourne. Professor Hogan is an NHMRC Senior Research Fellow and his work is currently funded by grants from the NHMRC, ARC and Bright Focus Foundation (USA).
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Understanding The Role Of Tissue Growth Pathways In Expansion Of The Lymphatic Vasculature
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flo..
Displaying the 13 most recent projects by Benjamin Hogan.
Displaying the 69 most recent scholarly works by Benjamin Hogan.
Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.
Kelly L Betterman, Drew L Sutton, Genevieve A Secker, Jan Kazenwadel, Anna Oszmiana, Lillian Lim, Naoyuki Miura, Lydia Sorokin, Benjamin M Hogan, Mark L Kahn, Helen McNeill, Natasha L Harvey
Journal article | 2020 | Journal of Clinical Investigation
The atypical cadherin FAT4 has established roles in the regulation of planar cell polarity and Hippo pathway signaling that are ce..
Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome.
Philip M Boone, Scott Paterson, Kiana Mohajeri, Wenmiao Zhu, Casie A Genetti, Derek JC Tai, Neeharika Nori, Pankaj B Agrawal, Carlos A Bacino, Weimin Bi, Michael E Talkowski, Benjamin M Hogan, Lance H Rodan
Journal article | 2020 | American Journal of Medical Genetics Part A
Hennekam lymphangiectasia-lymphedema syndrome is an autosomal recessive disorder characterized by congenital lymphedema, intestina..
Vegfc/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context
Celine J Vivien, Cathy Pichol-Thievend, Choon Boon Sim, Jacob B Smith, Neil Bower, Benjamin M Hogan, James E Hudson, Mathias Francois, Enzo R Porrello
Journal article | 2019 | npj Regenerative Medicine
Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis
Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen
Journal article | 2019 | Cell Reports
Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors
Tiffany CY Eng, Wenxuan Chen, Kazuhide S Okuda, June P Misa, Yvonne Padberg, Kathryn E Crosier, Philip S Crosier, Christopher J Hall, Stefan Schulte-Merker, Benjamin M Hogan, Jonathan W Astin
Journal article | 2019 | EMBO reports
Lymphatic vessels are known to be derived from veins; however, recent lineage-tracing experiments propose that specific lymphatic ..
Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk
Lin Grimm, Hiroyuki Nakajima, Smrita Chaudhury, Neil Bower, Kazuhide S Okuda, Andrew G Cox, Natasha L Harvey, Katarzyna Koltowska, Naoki Mochizuki, Benjamin M Hogan
Journal article | 2019 | eLife
The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage
Sungmin Baek, Tae Gyu Oh, Genevieve Secker, Drew L Sutton, Kazuhide S Okuda, Scott Paterson, Neil I Bower, John Toubia, Katarzyna Koltowska, Samuel J Capon, Gregory J Baillie, Cas Simons, George EO Muscat, Anne K Lagendijk, Kelly A Smith, Natasha L Harvey, Benjamin M Hogan
Journal article | 2019 | Developmental Cell
The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The..
Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling
Koji Ando, Weili Wang, Di Peng, Ayano Chiba, Anne K Lagendijk, Lindsey Barske, J Gage Crump, Didier YR Stainier, Urban Lendahl, Katarzyna Koltowska, Benjamin M Hogan, Shigetomo Fukuhara, Naoki Mochizuki, Christer Betsholtz
Journal article | 2019 | Development
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin-F-actin based oscillatory cell-cell interaction
Ilkka Paatero, Loic Sauteur, Minkyoung Lee, Anne K Lagendijk, Daniel Heutschi, Cora Wiesner, Camilo Guzman, Dimitri Bieli, Benjamin M Hogan, Markus Affolter, Heinz-Georg Belting
Journal article | 2018 | Nature Communications
Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume
Daniela R Grassini, Anne K Lagendijk, Jessica E De Angelis, Jason Da Silva, Angela Jeanes, Nicole Zettler, Neil I Bower, Benjamin M Hogan, Kelly A Smith
Journal article | 2018 | Development
A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development
Cathy Pichol-Thievend, Kelly L Betterman, Xiaolei Liu, Wanshu Ma, Renae Skoczylas, Emmanuelle Lesieur, Frank L Bos, Dorte Schulte, Stefan Schulte-Merker, Benjamin M Hogan, Guillermo Oliver, Natasha L Harvey, Mathias Francois
Journal article | 2018 | Development
Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish
Anne Karine Lagendijk, Guillermo A Gomez, Sungmin Baek, Daniel Hesselson, William E Hughes, Scott Paterson, Daniel E Conway, Heinz-Georg Belting, Markus Affolter, Kelly A Smith, Martin A Schwartz, Alpha S Yap, Benjamin M Hogan
Journal article | 2017 | Nature Communications
Junction-based lamellipodia drive endothelial cell rearrangements in vivo via a VE-cadherin/F-actin based oscillatory ratchet mechanism
Ilkka Paatero, Loïc Sauteur, Minkyoung Lee, Anne Lagendijk, Daniel Heutschi, Dimitri Bieli, Benjamin Hogan, Markus Affolter, Heinz-Georg Belting
Journal article | 2017
Abstract Angiogenesis and vascular remodeling are driven by a wide range of endothelial cell behaviors, such as cell divisions, ce..
Genome-wide functional analysis reveals central signaling regulators of lymphatic endothelial cell migration and remodeling
Steven P Williams, Adam F Odell, Tara Karnezis, Rae H Farnsworth, Cathryn M Gould, Jason Li, Sophie Paquet-Fifield, Nicole C Harris, Anne Walter, Julia L Gregory, Sara F Lamont, Ruofei Liu, Elena A Takano, Cameron J Nowell, Neil I Bower, Daniel Resnick, Gordon K Smyth, Leigh Coultas, Benjamin M Hogan, Stephen B Fox, et al.
Journal article | 2017 | Science Signaling
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development
Ivy Kim-Ni Chiang, Martin Fritzsche, Cathy Pichol-Thievend, Alice Neal, Kelly Holmes, Anne Lagendijk, Jeroen Overman, Donatella D'Angelo, Alice Omini, Dorien Hermkens, Emmanuelle Lesieur, Ke Liu, Indrika Ratnayaka, Monica Corada, George Bou-Gharios, Jason Carroll, Elisabetta Dejana, Stefan Schulte-Merker, Benjamin Hogan, Monica Beltrame, et al.
Journal article | 2017 | Development
Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish
Neil I Bower, Katarzyna Koltowska, Cathy Pichol-Thievend, Isaac Virshup, Scott Paterson, Anne K Lagendijk, Weili Wang, Benjamin W Lindsey, Stephen J Bent, Sungmin Baek, Maria Rondon-Galeano, Daniel G Hurley, Naoki Mochizuki, Cas Simons, Mathias Francois, Christine A Wells, Jan Kaslin, Benjamin M Hogan
Journal article | 2017 | Nature Neuroscience
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Jeroen Overman, Frank Fontaine, Mehdi Moustaqil, Deepak Mittal, Emma Sierecki, Natalia Sacilotto, Johannes Zuegg, Avril AB Robertson, Kelly Holmes, Angela A Salim, Sreeman Mamidyala, Mark S Butler, Ashley S Robinson, Emmanuelle Lesieur, Wayne Johnston, Kirill Alexandrov, Brian L Black, Benjamin M Hogan, Sarah De Val, Robert J Capon, et al.
Journal article | 2017 | eLife
Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover
Jessica E De Angelis, Anne K Lagendijk, Huijun Chen, Alisha Tromp, Neil I Bower, Kathryn A Tunny, Andrew J Brooks, Jeroen Bakkers, Mathias Francois, Alpha S Yap, Gas Simons, Carol Wicking, Benjamin M Hogan, Kelly A Smith
Journal article | 2017 | Developmental Cell
Vegfa signaling promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior cardinal vein
Andrew L Koenig, Kristina Baltrunaite, Neil I Bower, Andrea Rossi, Didier YR Stainier, Benjamin M Hogan, Saulius Sumanas
Journal article | 2016 | Developmental Biology
mafba is a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish
Katarzyna Koltowska, Scott Paterson, Neil I Bower, Gregory J Baillie, Anne K Lagendijk, Jonathan W Astin, Huijun Chen, Mathias Francois, Philip S Crosier, Ryan J Taft, Cas Simons, Kelly A Smith, Benjamin M Hogan
Journal article | 2015 | Genes & Development
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) Regulates Notch Signaling and Vascular Development in Zebrafish
Baptiste Coxam, Christine Neyt, Daniela R Grassini, Ludovic Le Guen, Kelly A Smith, Stefan Schulte-Merker, Benjamin M Hogan
Journal article | 2015 | Developmental Dynamics
Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development
Baptiste Coxam, Amelie Sabine, Neil I Bower, Kelly A Smith, Cathy Pichol-Thievend, Renae Skoczylas, Jonathan W Astin, Emmanuelle Frampton, Muriel Jaquet, Philip S Crosier, Robert G Parton, Natasha L Harvey, Tatiana V Petrova, Stefan Schulte-Merker, Mathias Francois, Benjamin M Hogan
Journal article | 2014 | Cell Reports
Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis
Ludovic Le Guen, Terhi Karpanen, Dorte Schulte, Nicole C Harris, Katarzyna Koltowska, Guy Roukens, Neil I Bower, Andreas van Impel, Steven A Stacker, Marc G Achen, Stefan Schulte-Merker, Benjamin M Hogan
Journal article | 2014 | Development
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development
Joelle Kartopawiro, Neil I Bower, Tara Karnezis, Jan Kazenwadel, Kelly L Betterman, Emmanuelle Lesieur, Katarzyna Koltowska, Jonathan Astin, Philip Crosier, Sonja Vermeren, Marc G Achen, Steven A Stacker, Kelly A Smith, Natasha L Harvey, Mathias Francois, Benjamin M Hogan
Journal article | 2014 | Human Molecular Genetics
VEGFD regulates blood vascular development by modulating SOX18 activity
Tam Duong, Katarzyna Koltowska, Cathy Pichol-Thievend, Ludovic Le Guen, Frank Fontaine, Kelly A Smith, Truong Vy, Renae Skoczylas, Steven A Stacker, Marc G Achen, Peter Koopman, Benjamin M Hogan, Mathias Francois
Journal article | 2014 | Blood
ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.
Garry HK Chang, Angelina J Lay, Ka Ka Ting, Yang Zhao, Paul R Coleman, Elizabeth E Powter, Ann Formaz-Preston, Christopher J Jolly, Neil I Bower, Benjamin M Hogan, Silke Rinkwitz, Thomas S Becker, Mathew A Vadas, Jennifer R Gamble
Journal article | 2014 | Small GTPases
The formation of the vascular network requires a tightly controlled balance of pro-angiogenic and stabilizing signals. Perturbatio..
In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation
Maria-Cristina Keightley, Meredith O Crowhurst, Judith E Layton, Traude Beilharz, Sebastian Markmiller, Sony Varma, Benjamin M Hogan, Tanya A de Jong-Curtain, Joan K Heath, Graham J Lieschke
Journal article | 2013 | FEBS Letters
Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish
Solei Cermenati, Silvia Moleri, Christine Neyt, Erica Bresciani, Silvia Carra, Daniela R Grassini, Alice Omini, Michela Goi, Franco Cotelli, Mathias Francois, Benjamin M Hogan, Monica Beltrame
Journal article | 2013 | Arteriosclerosis, Thrombosis, and Vascular Biology
The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling
Maria L Macheda, Willy W Sun, Kumudhini Kugathasan, Benjamin M Hogan, Neil I Bower, Michael M Halford, You Fang Zhang, Bonnie E Jacques, Graham J Lieschke, Alain Dabdoub, Steven A Stacker
Journal article | 2012 | Journal of Biological Chemistry
Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development
Kelly A Smith, Anne K Lagendijk, Andrew D Courtney, Huijun Chen, Scott Paterson, Benjamin M Hogan, Carol Wicking, Jeroen Bakkers
Journal article | 2011 | Development
Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish
Ilse Geudens, Robert Herpers, Karlien Hermans, Inmaculada Segura, Carmen Ruiz de Almodovar, Jeroen Bussmann, Frederik De Smet, Wouter Vandevelde, Benjamin M Hogan, Arndt Siekmann, Filip Claes, John C Moore, Anna Silvia Pistocchi, Sonja Loges, Massimiliano Mazzone, Giovanni Mariggi, Francoise Bruyere, Franco Cotelli, Dontscho Kerjaschki, Agnes Noel, et al.
Journal article | 2010 | Arteriosclerosis, Thrombosis, and Vascular Biology
Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans
Marielle Alders, Benjamin M Hogan, Evisa Gjini, Faranak Salehi, Lihadh Al-Gazali, Eric A Hennekam, Eva E Holmberg, Marcel MAM Mannens, Margot F Mulder, G Johan A Offerhaus, Trine E Prescott, Eelco J Schroor, Joke BGM Verheij, Merlijn Witte, Petra J Zwijnenburg, Mikka Vikkula, Stefan Schulte-Merker, Raoul C Hennekam
Journal article | 2009 | Nature Genetics
Functional Analyses of Human and Zebrafish 18-Amino Acid In-Frame Deletion Pave the Way for Domain Mapping of the Cerebral Cavernous Malformation 3 Protein
Katrin Voss, Sonja Stahl, Benjamin M Hogan, Joerg Reinders, Elisa Schleider, Stefan Schulte-Merker, Ute Felbor
Journal article | 2009 | Human Mutation
Simple and efficient transgenesis with meganuclease constructs in zebrafish.
Daniele Soroldoni, Benjamin M Hogan, Andrew C Oates
Journal article | 2009 | Methods in molecular biology (Clifton, N.J.)
In the past, microinjection of plasmid DNA into early embryos represented the state of the art to generate transgenic zebrafish. H..
Manipulation of gene expression during zebrafish embryonic development using transient approaches.
Benjamin M Hogan, Heather Verkade, Graham J Lieschke, Joan K Heath
Other | 2008 | Methods Mol. Biol.
The rapid embryonic development and high fecundity of zebrafish contribute to the great advantages of this model for the study of ..
CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish
Sebastian Dworkin, Joan K Heath, Tanya A deJong-Curtain, Benjamin M Hogan, Graham J Lieschke, Jordane Malaterre, Robert G Ramsay, Theo Mantamadiotis
Journal article | 2007 | Developmental Biology
Honours, Awards and Fellowships
NHMRCF - NHMRC Fellowship
NHMRCF - NHMRC Fellowship
FARC - Fellow of the Australian Research Council
CJMARTIN - C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia)
EMBO Long term fellow
Cancer council postdoctoral fellow
Anatomy And Neuroscience
The Sir Peter Maccallum Department Of Oncology
Doctor of Philosophy
University of Melbourne
Bachelor of Science with honours
University of Melbourne