Benjamin Hogan

Single-cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish development

Lin Grimm, Elizabeth Mason, Hujun Yu, Stefanie Dudczig, Virginia Panara, Tyrone Chen, Neil Bower, Scott Paterson, Maria Rondon Galeano, Sakurako Kobayashi, Anne Senabouth, Anne K Lagendijk, Joseph Powell, Kelly A Smith, Kazuhide S Okuda, Katarzyna Koltowska, Benjamin M Hogan

Journal article  |  2023  |  EMBO JOURNAL

During development, the lymphatic vasculature forms as a second network derived chiefly from blood vessels. The transdifferentiati..

No crops without seeds: the risks in declining support for fundamental research

Benjamin M Hogan, Mark L Kahn, Natasha L Harvey

Journal article  |  2023  |  Nature Cardiovascular Research

ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma

Kimberly J Morgan, Karen Doggett, Fansuo Geng, Stephen Mieruszynski, Lachlan Whitehead, Kelly A Smith, Benjamin M Hogan, Cas Simons, Gregory J Baillie, Ramyar Molania, Anthony T Papenfuss, Thomas E Hall, Elke A Ober, Didier YR Stainier, Zhiyuan Gong, Joan K Heath

Journal article  |  2023  |  ELIFE

The nucleoporin (NUP) ELYS, encoded by AHCTF1, is a large multifunctional protein with essential roles in nuclear pore assembly an..

Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature

Tevin CY Chau, Mikaela S Keyser, Jason A Da Silva, Elysse K Morris, Teodor E Yordanov, Kinga P Duscyz, Scott Paterson, Alpha S Yap, Benjamin M Hogan, Anne Karine Lagendijk

Journal article  |  2022  |  DEVELOPMENT

The assembly of a mature vascular network involves coordinated endothelial cell (EC) shape changes, including the process of EC el..

Plexin D1 negatively regulates zebrafish lymphatic development.

Denver D Britto, Jia He, June P Misa, Wenxuan Chen, Purvi M Kakadia, Lin Grimm, Caitlin D Herbert, Kathryn E Crosier, Philip S Crosier, Stefan K Bohlander, Benjamin M Hogan, Christopher J Hall, Jesús Torres-Vázquez, Jonathan W Astin

Journal article  |  2022  |  Development

Lymphangiogenesis is a dynamic process that involves the directed migration of lymphatic endothelial cells (LECs) to form lymphati..

mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners

Hannah Arnold, Virginia Panara, Melina Hussmann, Beata Filipek-Gorniok, Renae Skoczylas, Petter Ranefall, Marleen Gloger, Amin Allalou, Benjamin M Hogan, Stefan Schulte-Merker, Katarzyna Koltowska

Journal article  |  2022  |  CELL REPORTS

Lymphangiogenesis, formation of lymphatic vessels from pre-existing vessels, is a dynamic process that requires cell migration. Re..

Blood vessel occlusion by Cryptococcus neoformans is a mechanism for haemorrhagic dissemination of infection.

Josie F Gibson, Aleksandra Bojarczuk, Robert J Evans, Alfred Alinafe Kamuyango, Richard Hotham, Anne K Lagendijk, Benjamin M Hogan, Philip W Ingham, Stephen A Renshaw, Simon A Johnston

Journal article  |  2022  |  PLoS Pathog

Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause ..

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  NATURE CELL BIOLOGY

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

Pkd1 and Wnt5a genetically interact to control lymphatic vascular morphogenesis in mice

Tevin CY Chau, Sungmin Baek, Baptiste Coxam, Renae Skoczylas, Maria Rondon-Galeano, Neil I Bower, Elanor N Wainwright, Steven A Stacker, Helen M Cooper, Peter A Koopman, Anne K Lagendijk, Natasha L Harvey, Mathias Francois, Benjamin M Hogan

Journal article  |  2021  |  DEVELOPMENTAL DYNAMICS

BACKGROUND: Lymphatic vascular development is regulated by well-characterized signaling and transcriptional pathways. These pathwa..

3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

Kazuhide S Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S Crosier, Katarzyna Koltowska, Jonathan W Astin, Pei Jean Tan, Benjamin M Hogan, Vyomesh Patel

Journal article  |  2021  |  Pharmaceuticals

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, includin..