Lachlan Coin

Data-driven estimation of COVID-19 community prevalence through wastewater-based epidemiology

Xuan Li, Jagadeeshkumar Kulandaivelu, Shuxin Zhang, Jiahua Shi, Muttucumaru Sivakumar, Jochen Mueller, Stephen Luby, Warish Ahmed, Lachlan Coin, Guangming Jiang

Journal article  |  2021  |  SCIENCE OF THE TOTAL ENVIRONMENT

Wastewater-based epidemiology (WBE) has been regarded as a potential tool for the prevalence estimation of coronavirus disease 201..

Signatures of TSPAN8 variants associated with human metabolic regulation and diseases

Tisham De, Angela Goncalves, Doug Speed, Philippe Froguel, Daniel J Gaffney, Michael R Johnson, Marjo-Riitta Jarvelin, Lachlan JM Coin

Journal article  |  2021  |  ISCIENCE

Here, with the example of common copy number variation (CNV) in the TSPAN8 gene, we present an important piece of work in the fiel..

No evidence of SARS-CoV-2 reversetranscription and integration as the origin of chimeric transcripts in patient tissues

Rhys Parry, Robert J Gifford, Spyros Lytras, Stuart C Ray, Lachlan JM Coin

Journal article  |  2021  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimising Treatment Outcomes for Children and Adults Through Rapid Genome Sequencing of Sepsis Pathogens. A Study Protocol for a Prospective, Multi-Centre Trial (DIRECT)

Adam D Irwin, Lachlan JM Coin, Patrick NA Harris, Menino Osbert Cotta, Michelle J Bauer, Cameron Buckley, Ross Balch, Peter Kruger, Jason Meyer, Kiran Shekar, Kara Brady, Cheryl Fourie, Natalie Sharp, Luminita Vlad, David Whiley, Scott A Beatson, Brian M Forde, David Paterson, Julia Clark, Krispin Hajkowicz, et al.

Journal article  |  2021  |  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Background: Sepsis contributes significantly to morbidity and mortality globally. In Australia, 20,000 develop sepsis every year, ..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  CELL REPORTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..

Genomic epidemiology of tuberculosis in eastern Malaysia: insights for strengthening public health responses

Arnold Bainomugisa, Ella M Meumann, Giri Shan Rajahram, Rick Twee-Hee Ong, Lachlan Coin, Dawn Carmel Paul, Timothy William, Christopher Coulter, Anna P Ralph

Journal article  |  2021  |  MICROBIAL GENOMICS

Tuberculosis is a leading public health priority in eastern Malaysia. Knowledge of the genomic epidemiology of tuberculosis can he..

New technologies for diagnosing active TB: the VANTDET diagnostic accuracy study

Alice Halliday, Pooja Jain, Long Hoang, Robert Parker, Mica Tolosa-Wright, Tereza Masonou, Nathan Green, Aime Boakye, Yemisi Takwoingi, Shea Hamilton, Vinay Mandagere, Anastasia Fries, Lachlan Coin, Jon Deeks, Peter J White, Michael Levin, Peter Beverley, Onn Min Kon, Ajit Lalvani

Journal article  |  2021  |  Efficacy and Mechanism Evaluation

BackgroundTuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed.ObjectiveTo validate pr..

Real-time resolution of short-read assembly graph using ONT long reads

Son Hoang Nguyen, Minh Duc Cao, Lachlan JM Coin

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

A streaming assembly pipeline utilising real-time Oxford Nanopore Technology (ONT) sequencing data is important for saving sequenc..

Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification.

Harriet D Gliddon, Myrsini Kaforou, Mary Alikian, Dominic Habgood-Coote, Chenxi Zhou, Tolu Oni, Suzanne T Anderson, Andrew J Brent, Amelia C Crampin, Brian Eley, Robert Heyderman, Florian Kern, Paul R Langford, Tom HM Ottenhoff, Martin L Hibberd, Neil French, Victoria J Wright, Hazel M Dockrell, Lachlan J Coin, Robert J Wilkinson, et al.

Journal article  |  2021  |  Front Immunol

Recently, host whole blood gene expression signatures have been identified for diagnosis of tuberculosis (TB). Absolute quantifica..

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Tim Stinear, Sarah Londrigan, Michael Clark, Deborah Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2020

Summary SARS-CoV-2 uses subgenomic (sg)RNA to produce viral proteins for replication and immune evasion. We applied long-read RNA ..