Matthew Philip Hardy

A novel soluble complement receptor 1 fragment with enhanced therapeutic potential.

Sandra Wymann, Yun Dai, Anup G Nair, Helen Cao, Glenn A Powers, Anna Schnell, Genevieve Martin-Roussety, David Leong, Jason Simmonds, Kim G Lieu, Mitchell J de Souza, Marcel Mischnik, Shirley Taylor, Saw Yen Ow, Martin Spycher, Rebecca E Butcher, Martin Pearse, Adrian W Zuercher, Adriana Baz Morelli, Con Panousis, et al.

Journal article  |  2021  |  J Biol Chem

Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a me..

Glycoproteomic measurement of site-specific polysialylation.

Ruby Pelingon, Cassandra L Pegg, Lucia F Zacchi, Toan K Phung, Christopher B Howard, Ping Xu, Matthew P Hardy, Catherine M Owczarek, Benjamin L Schulz

Journal article  |  2020  |  Anal Biochem

Polysialylation is the enzymatic addition of a highly negatively charged sialic acid polymer to the non-reducing termini of glycan..

Optimizing high throughput antibody purification by using continuous chromatography media.

Rebecca E Butcher, Genevieve Martin-Roussety, Rebecca A Bradford, Andrea Tester, Catherine Owczarek, Matthew P Hardy, Chao-Guang Chen, Georgina Sansome, Louis J Fabri, Peter M Schmidt

Journal article  |  2019  |  Protein Expr Purif

The ability to engineer monoclonal antibodies (mAbs) with high specificity made mAbs the fastest growing segment in the drug marke..

Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins

Stephanie Trezise, Alexander Karnowski, Pasquale L Fedele, Sridurga Mithraprabhu, Yang Liao, Kathy D'Costa, Andrew J Kueh, Matthew P Hardy, Catherine M Owczarek, Marco J Herold, Andrew Spencer, Wei Shi, Simon N Willis, Stephen L Nutt, Lynn M Corcoran

Journal article  |  2018  |  International Journal of Molecular Sciences

Antibody Secreting Cells (ASCs) are a fundamental component of humoral immunity, however, deregulated or excessive antibody produc..

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Christian A Schaer, Catherine Owczarek, Jeremy W Deuel, Stefan Schauer, Jin Hyen Baek, Ayla Yalamanoglu, Matthew P Hardy, Pierre D Scotney, Peter M Schmidt, Matthias Pelzing, Peter Soupourmas, Paul W Buehler, Dominik J Schaer

Journal article  |  2018  |  BMC Biotechnol

BACKGROUND: Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to atte..

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling

Sophie E Broughton, Timothy R Hercus, Tracy L Nero, Winnie L Kan, Emma F Barry, Mara Dottore, Karen S Cheung Tung Shing, Craig J Morton, Urmi Dhagat, Matthew P Hardy, Nicholas J Wilson, Matthew T Downton, Christine Schieber, Timothy P Hughes, Angel F Lopez, Michael W Parker

Journal article  |  2018  |  NATURE COMMUNICATIONS

The interleukin-3 (IL-3) receptor is a cell-surface heterodimer that links the haemopoietic, vascular and immune systems and is ov..

A neutralizing anti-G-CSFR antibody blocks G-CSF-induced neutrophilia without inducing neutropenia in nonhuman primates.

Karen Scalzo-Inguanti, Katherine Monaghan, Kirsten Edwards, Eva Herzog, Danijela Mirosa, Matthew Hardy, Vicki Sorto, Huy Huynh, Steven Rakar, Daria Kurtov, Hal Braley, Nick Wilson, Samantha Busfield, Andrew Nash, Arna Andrews

Journal article  |  2017  |  J Leukoc Biol

Neutrophils are the most abundant WBCs and have an essential role in the clearance of pathogens. Tight regulation of neutrophil nu..

The Core Domain of Hepatitis C Virus Glycoprotein E2 Generates Potent Cross-Neutralizing Antibodies in Guinea Pigs

Patricia T Vietheer, Irene Boo, Jun Gu, Kathleen McCaffrey, Stirling Edwards, Catherine Owczarek, Matthew P Hardy, Louis Fabri, Rob J Center, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2017  |  HEPATOLOGY

A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging global elimination program. Ho..

An Optimized Hepatitis C Virus E2 Glycoprotein Core Adopts a Functional Homodimer That Efficiently Blocks Virus Entry

Kathleen McCaffrey, Irene Boo, Catherine M Owczarek, Matthew P Hardy, Matthew A Perugini, Louis Fabri, Pierre Scotney, Pantelis Poumbourios, Heidi E Drummer

Journal article  |  2017  |  JOURNAL OF VIROLOGY

The hepatitis C virus (HCV) envelope glycoprotein E2 is the major target of broadly neutralizing antibodies in vivo and is the foc..

A robust robotic high-throughput antibody purification platform.

Peter M Schmidt, Michael Abdo, Rebecca E Butcher, Min-Yin Yap, Pierre D Scotney, Melanie L Ramunno, Genevieve Martin-Roussety, Catherine Owczarek, Matthew P Hardy, Chao-Guang Chen, Louis J Fabri

Journal article  |  2016  |  J Chromatogr A

Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion ..