Amir Iravani

Prognostic biomarkers in men with metastatic castration-resistant prostate cancer receiving [177Lu]-PSMA-617.

Justin Ferdinandus, John Violet, Shahneen Sandhu, Rodney J Hicks, Aravind S Ravi Kumar, Amir Iravani, Grace Kong, Tim Akhurst, Sue Ping Thang, Declan G Murphy, Scott Williams, Michael S Hofman

Journal article  |  2020  |  European Journal of Nuclear Medicine and Molecular Imaging

PURPOSE: We analysed quantitative biomarkers derived from both baseline whole-body imaging and blood serum to identify prognostic ..

Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer

Amir Iravani

Journal article  |  2020  |  Journal of Urology

Lutetium-177 prostate-specific membrane antigen (PSMA) theranostics: practical nuances and intricacies

Amir Iravani, John Violet, Arun Azad, Michael S Hofman

Journal article  |  2020  |  Prostate Cancer and Prostatic Diseases

Theranostic principles utilize a molecular biomarker specific for a tumor target, initially for imaging to assess target expressio..

A Malignant Neoplasm From the Jejunum With a MALAT1-GLI1 Fusion and 26-Year Survival History

Owen William John Prall, Christopher Robert Edward McEvoy, David John Byrne, Amir Iravani, Judy Browning, David Yew-Huong Choong, Bhargavi Yellapu, Sophie O'Haire, Kortnye Smith, Stephen James Luen, Paul Leslie Ross Mitchell, Jayesh Desai, Stephen Bernard Fox, Andrew Fellowes, Huiling Xu

Journal article  |  2020  |  International Journal of Surgical Pathology

The transcription factor GLI1 is a critical effector of the sonic hedgehog pathway. Gene fusions that activate GLI1 have recently ..

18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Assessing Tumor Response to Immunotherapy in Solid Tumors Melanoma and Beyond

Rodney J Hicks, Amir Iravani, Shahneen Sandhu

Journal article  |  2020  |  PET Clinics

The complexity of the immune response and diversity of targets challenges conventional conceptual frameworks used in selecting and..

Prostate-Specific Membrane Antigen Ligand Positron Emission Tomography in Men with Nonmetastatic Castration-Resistant Prostate Cancer

Wolfgang P Fendler, Manuel Weber, Amir Iravani, Michael S Hofman, Jeremie Calais, Johannes Czernin, Harun Ilhan, Fred Saad, Eric J Small, Matthew R Smith, Paola M Perez, Thomas A Hope, Isabel Rauscher, Anil Londhe, Angela Lopez-Gitlitz, Shinta Cheng, Tobias Maurer, Ken Herrmann, Matthias Eiber, Boris Hadaschik

Journal article  |  2019  |  Clinical Cancer Research

PURPOSE: Systemic androgen-signaling inhibition added to ongoing androgen-deprivation therapy (ADT) improved clinical outcomes in ..

Long term follow-up and outcomes of re-treatment in an expanded 50 patient single-center phase II prospective trial of Lutetium-177 (177Lu) PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

John Violet, Shahneen Sandhu, Amir Iravani, Justin Ferdinandus, Sue Ping Thang, Grace Kong, Aravind Ravi Kumar, Tim Akhurst, David A Pattison, Alexis Beaulieu, Jennifer Mooi, Christina Guo, Victor Kalff, Declan G Murphy, Price Jackson, Peter Eu, Mark Scalzo, Scott Williams, Rod J Hicks, Michael S Hofman

Journal article  |  2019  |  Journal of Nuclear Medicine

Objectives: Lutetium-177 (177Lu)-PSMA-617 (LuPSMA) is a radioligand with high affinity for prostate specific membrane antigen (PSM..

The Role of 68Ga-DOTA-Octreotate PET/CT in Follow-Up of SDH-Associated Pheochromocytoma and Paraganglioma

Grace Kong, Tess Schenberg, Christopher J Yates, Alison Trainer, Nirupa Sachithanandan, Amir Iravani, Aravind Ravi Kumar, Michael S Hofman, Tim Akhurst, Michael Michael, Rodney J Hicks

Journal article  |  2019  |  The Journal of Clinical Endocrinology & Metabolism

Purpose: Germline succinate dehydrogenase (SDHx) mutation carriers, especially SDHB, are at increased risk for malignancy and requ..

Mitogen-Activated Protein Kinase Pathway Inhibition for Redifferentiation of Radioiodine Refractory Differentiated Thyroid Cancer: An Evolving Protocol

Amir Iravani, Benjamin Solomon, David A Pattison, Price Jackson, Aravind Ravi Kumar, Grace Kong, Michael S Hofman, Tim Akhurst, Rodney J Hicks

Journal article  |  2019  |  Thyroid

Background: Some patients with metastatic differentiated thyroid cancer (DTC) lack iodine avidity and are the..

Poor Outcomes for Patients with Metastatic Castration-resistant Prostate Cancer with Low Prostate-specific Membrane Antigen (PSMA) Expression Deemed Ineligible for 177Lu-labelled PSMA Radioligand Therapy

Sue Ping Thang, John Violet, Shahneen Sandhu, Amir Iravani, Tim Akhurst, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Scott G Williams, Rodney J Hicks, Michael S Hofman

Journal article  |  2019  |  European Urology Oncology

BACKGROUND: Prostate-specific membrane antigen (PSMA) is overexpressed in metastatic castration-resistant prostate cancer (mCRPC) ..

TheraP: a randomized phase 2 trial of Lu-177-PSMA-617 theranostic treatment vs cabazitaxel in progressive metastatic castration-resistant prostate cancer (Clinical Trial Protocol ANZUP 1603)

Michael S Hofman, Louise Emmett, John Violet, Alison Y Zhang, Nicola J Lawrence, Martin Stockler, Roslyn J Francis, Amir Iravani, Scott Williams, Arun Azad, Andrew Martin, Margaret McJannett, Ian D Davis

Journal article  |  2019  |  BJU International

OBJECTIVE: To assess the activity and safety of cabazitaxel chemotherapy vs that of treatment with 177 Lu-PSMA-617, a novel radiol..

Prostate-Specific Membrane Antigen Positron-Emission Tomography (PSMA-PET) in High-Risk Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC) SPARTAN-like Patients Negative by Conventional Imaging

W Fendler, M Weber, A Iravani, MS Hofman, J Calais, J Czernin, H Ilhan, F Saad, EJ Small, MR Smith, PM Perez, A Hope, I Rauscher, A Londhe, A Lopez-Gitlitz, S Cheng, T Maurer, K Herrmann, B Hadaschik, M Eiber

Conference Proceedings  |  2019  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET-detected pneumonitis following curative-intent chemoradiation in non-small cell lung cancer (NSCLC): recognizing patterns and assessing the impact on the predictive ability of FDG-PET/CT response assessment

Amir Iravani, Guy-Anne Turgeon, Tim Akhurst, Jason W Callahan, Mathias Bressel, Sarah J Everitt, Shankar Siva, Michael S Hofman, Rodney J Hicks, David L Ball, Michael P Mac Manus

Journal article  |  2019  |  European Journal of Nuclear Medicine and Molecular Imaging

Characteristics and outcomes of therapy-related myeloid neoplasms after peptide receptor radionuclide/chemoradionuclide therapy (PRRT/PRCRT) for metastatic neuroendocrine neoplasia: a single-institution series

Isaac Goncalves, Kate Burbury, Michael Michael, Amir Iravani, Aravind S Ravi Kumar, Tim Akhurst, Ing S Tiong, Piers Blombery, Michael S Hofman, David Westerman, Rodney J Hicks, Grace Kong

Journal article  |  2019  |  European Journal of Nuclear Medicine and Molecular Imaging

Independent and incremental value of ventilation/perfusion PET/CT and CT pulmonary angiography for pulmonary embolism diagnosis: results of the PECAN pilot study

Pierre-Yves Le Roux, Amir Iravani, Jason Callahan, Kate Burbury, Peter Eu, Daniel P Steinfort, Eddie Lau, Beverly Woon, Pierre-Yves Salaun, Rodney J Hicks, Michael S Hofman

Journal article  |  2019  |  European Journal of Nuclear Medicine and Molecular Imaging

The role of F-18-FDG-PET/CT in evaluating retroperitoneal masses -Keeping your eye on the ball!

Te-Jui Hung, Luke McLean, Catherine Mitchell, Claire Pascoe, Nathan Lawrentschuk, Declan G Murphy, Amir Iravani, Dalveer Singh, Michael S Hofman, Lamiaa Zidan, Tim Akhurst, Jeremy Lewin, Rodney J Hicks

Journal article  |  2019  |  Cancer Imaging

Intra-individual comparison of Ga-68-PSMA-11 and F-18-DCFPyL normal-organ biodistribution

Goncalo Ferreira, Amir Iravani, Michael S Hofman, Rodney J Hicks

Journal article  |  2019  |  Cancer Imaging

Independent and incremental value of Ventilation/Perfusion PET/CT and CT pulmonary angiography for pulmonary embolism diagnosis: results of the PECAN pilot study

Pierre Yves Le Roux, Amir Iravani, Jason Callahan, Kate Burbury, Peter Eu, Daniel Steinfort, Eddie Lau, Pierre Salaun, Rodney Hicks, Michael Hofman

Conference Proceedings  |  2019  |  JOURNAL OF NUCLEAR MEDICINE

PSMA-PET localizes M1 Disease in more than half of "non-metastatic" Castration-Resistant Prostate Cancer Patients

Wolfgang Fendler, Manuel Weber, Amir Iravani, Michael Hofman, Jeremie Calais, Johannes Czernin, Harun Ilhan, Tobias Maurer, Ken Herrmann, Thomas Hope, Isabel Rauscher, Boris Hadaschik, Matthias Eiber

Conference Proceedings  |  2019  |  JOURNAL OF NUCLEAR MEDICINE

Response assessment and immune-related adverse events as detected by FDG PET/CT in patients treated with combined CTLA-4 and PD-1 checkpoint inhibitors as first line therapy in advanced melanoma

Amir Iravani, Medhat Osman, Michael Hofman, Alison Weppler, George Au-Yeung, Shahneen Sandhu, Rodney Hicks

Conference Proceedings  |  2019  |  JOURNAL OF NUCLEAR MEDICINE

Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion

Christopher R McEvoy, Huiling Xu, Kortnye Smith, Dariush Etemadmoghadam, Huei San Leong, David Y Choong, David J Byrne, Amir Iravani, Sophie Beck, Linda Mileshkin, Richard W Tothill, David D Bowtell, Bindi M Bates, Violeta Nastevski, Judy Browning, Anthony H Bell, Chloe Khoo, Jayesh Desai, Andrew P Fellowes, Stephen B Fox, et al.

Journal article  |  2019  |  Journal of Clinical Investigation

Dosimetry of Lu-177-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer: Correlations Between Pretherapeutic Imaging and Whole-Body Tumor Dosimetry with Treatment Outcomes

John Violet, Price Jackson, Justin Ferdinandus, Shahneen Sandhu, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Sue Ping Thang, Peter Eu, Mark Scalzo, Declan Murphy, Scott Williams, Rodney J Hicks, Michael S Hofman

Journal article  |  2019  |  Journal of Nuclear Medicine

PATTERNS AND PREVALENCE OF IMMUNE-RELATED ADVERSE EVENTS AS DETECTED WITH FDG PET/CT IN PATIENTS TREATED WITH COMBINED CTLA-4 AND PD-1 INHIBITOR AS FIRST-LINE THERAPY FOR ADVANCED MELANOMA

A Iravani, MM Osman, MS Hofman, A Weppler, G Au-Yeung, S Sandhu, RJ Hicks

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

PROSTATE-SPECIFIC MEMBRANE ANTIGEN POSITRON EMISSION TOMOGRAPHY (PSMA-PET) IN HIGH-RISK NONMETASTATIC CASTRATION-RESISTANT PROSTATE CANCER (NMCRPC) SPARTAN-LIKE PATIENTS (PTS) NEGATIVE BY CONVENTIONAL IMAGING

Boris Hadaschik, Manuel Weber, Amir Iravani, Michael S Hofman, Jeremie Calais, Johannes Czernin, Harun Ilhan, Fred Saad, Eric J Small, Matthew R Smith, Paola M Perez, Thomas A Hope, Isabel Rauscher, Anil Londhe, Angela Lopez-Gitlitz, Shinta Cheng, Tobias Maurer, Ken Herrmann, Matthias Eiber, Wolfgang Fendler

Conference Proceedings  |  2019  |  JOURNAL OF UROLOGY

WELL-DIFFERENTIATED NEUROENDOCRINE NEOPLASM (NEN) WITH NO OR LOW (68)GA-DOTATATE AND F-18-FDG-AVIDITY: AN UNDER-RECOGNISED MOLECULAR IMAGING PHENOTYPE AND POTENTIAL MIMICKING PITFALLS

L Zidan, T Hung, G Kong, T Akhurst, A Ravikumar, M Hofman, R Hicks, A Iravani

Conference Proceedings  |  2019  |  INTERNAL MEDICINE JOURNAL

PSMA-PET results in a nonmetastatic castration-resistant prostate cancer spartan-like population that is negative by conventional imaging

M Hofman, W Fendler, M Weber, A Iravani, J Calais, J Czernin, H Ilhan, E Small, M Smith, T Maurer, K Herrmann, P Perez, T Hope, I Rauscher, A Londhe, A Lopez-Gitlitz, S Cheng, M Eiber, B Hadaschik

Conference Proceedings  |  2019  |  BJU INTERNATIONAL

TheraP: A randomized phase II trial of [Lu-177]-PSMA-617 theranostic versus cabazitaxel in progressive metastatic castration-resistant prostate cancer

Michael Hofman, Louise Emmett, John A Violet, Nicola Jane Lawrence, Scott Williams, Martin R Stockler, Roslyn J Francis, Amir Iravani, Alison Yan Zhang, Andrew James Martin, Arun Azad, Sonia Yip, Ailsa Langford, Margaret Mary McJannett, Ian D Davis

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

What F-18-FDG PET Response-Assessment Method Best Predicts Survival After Curative-Intent Chemoradiation in Non-Small Cell Lung Cancer: EORTC, PERCIST, Peter Mac Criteria, or Deauville Criteria?

Guy-Anne Turgeon, Amir Iravani, Tim Akhurst, Alexis Beaulieu, Jason W Callahan, Mathias Bressel, Aidan J Cole, Sarah J Everitt, Shankar Siva, Rodney J Hicks, David L Ball, Michael P Mac Manus

Journal article  |  2019  |  Journal of Nuclear Medicine

Results of a 50 patient single-center phase II prospective trial of Lutetium-177 PSMA-617 theranostics in metastatic castrate-resistant prostate cancer.

Michael Hofman, John A Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Timothy J Akhurst, Jennifer Mooi, Christina Guo, Ben Tran, Price Jackson, Mark Scalzo, Peter Eu, Scott Williams, Shahneen Kaur Sandhu

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Theranostics for Advanced Prostate Cancer: Current Indications and Future Developments.

Andrea Farolfi, Wolfgang Fendler, Amir Iravani, Uwe Haberkorn, Rodney Hicks, Ken Herrmann, Jochen Walz, Stefano Fanti

Journal article  |  2019  |  European Urology Oncology

CONTEXT: Advanced prostate cancer (PCa) is a prominent cause of cancer death in men; positron emission tomography (PET) imaging ma..

The "ProPSMA Study" clinical trial protocol: A prospective randomized multi-center study of the impact of Ga-68 PSMA PET/CT imaging for staging high-risk prostate cancer prior to curative-intent surgery or radiotherapy.

Michael Hofman, Declan G Murphy, Scott Williams, Tatenda Nzenza, Alan Herschtal, Anetta Matera, Petra Marusic, Richard De Abreu Lourenco, Dale L Bailey, Amir Iravani, Rodney J Hicks, Roslyn J Francis, Nathan Lawrentschuk

Conference Proceedings  |  2019  |  Journal of Clinical Oncology

Characteristics and Outcomes of Therapy-Related Myeloid Neoplasms after Peptide Receptor Radionuclide Therapy (PRRT) for Metastatic Neuroendocrine Neoplasm (NEN): A Single Centre Series

I Goncalves, K Burbury, D Westerman, P Blombery, IS Tiong, A Iravani, A Ravikumar, M Michael, M Hofman, T Akhurst, R Hicks, G Kong

Conference Proceedings  |  2019  |  NEUROENDOCRINOLOGY

Induction PRRT With CAPTEM Chemotherapy in a High-risk Population of Metastatic Neuroendocrine Neoplasia (NEN): Balancing Efficacy With Risk

AS Ravi Kumar, J Ferdinandus, J Callahan, T Akhurst, MS Hofman, A Iravani, G Kong, M Michael, RJ Hicks

Conference Proceedings  |  2018  |  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

THE ROLE OF (68)GA-DOTA-OCTREOTATE (GATATE) PET/CT IN FOLLOW-UP OF PATIENTS WITH SDH-ASSOCIATED PHEOCHROMOCYTOMA AND PARAGANGLIOMA (PPGL)

G Kong, T Schenberg, A Iravani, M Hofman, A Ravikumar, T Akhurst, R Hicks

Conference Proceedings  |  2018  |  INTERNAL MEDICINE JOURNAL

Ga-68 PSMA-11 PET with CT urography protocol in the initial staging and biochemical relapse of prostate cancer

Amir Iravani, Michael S Hofman, Tony Mulcahy, Scott Williams, Declan Murphy, Bimal K Parameswaran, Rodney J Hicks

Journal article  |  2017  |  Cancer Imaging