Imran Geoffrey House

Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid YN Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, et al.

Journal article  |  2022  |  CANCER CELL

There is increasing recognition of the prognostic significance of tumor cell major histocompatibility complex (MHC) class II expre..

CD4( ) CAR T cells persist long-term CD4( ) chimeric antigen receptor T cells in for the long journey

Amanda XY Chen, Emily B Derrick, Paul A Beavis, Imran G House

Journal article  |  2022  |  IMMUNOLOGY AND CELL BIOLOGY

In a recently published article, Melenhorst et al. performed a longitudinal analysis on chimeric antigen receptor (CAR) T cells is..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy

Lauren Giuffrida, Kevin Sek, Melissa A Henderson, Junyun Lai, Amanda XY Chen, Deborah Meyran, Kirsten L Todd, Emma Petley, Sherly Mardiana, Christina Molck, Gregory D Stewart, Benjamin J Solomon, Ian A Parish, Paul J Neeson, Simon J Harrison, Lev M Kats, Imran G House, Phillip K Darcy, Paul A Beavis

Journal article  |  2021  |  NATURE COMMUNICATIONS

Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets includ..

Efficient CRISPR/Cas9 Gene Editing in Uncultured Naive Mouse T Cells for In Vivo Studies

Simone Nussing, Imran G House, Conor J Kearney, Amanda XY Chen, Stephin J Vervoort, Paul A Beavis, Jane Oliaro, Ricky W Johnstone, Joseph A Trapani, Ian A Parish

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

Imran G House, Peter Savas, Junyun Lai, Amanda XY Chen, Amanda J Oliver, Zhi L Teo, Kirsten L Todd, Melissa A Henderson, Lauren Giuffrida, Emma V Petley, Kevin Sek, Sherly Mardiana, Tuba N Gide, Camelia Quek, Richard A Scolyer, Georgina V Long, James S Wilmott, Sherene Loi, Phillip K Darcy, Paul A Beavis

Journal article  |  2020  |  CLINICAL CANCER RESEARCH

PURPOSE: Response rates to immune checkpoint blockade (ICB; anti-PD-1/anti-CTLA-4) correlate with the extent of tumor immune infil..

Tissue-specific tumor microenvironments influence responses to immunotherapies

Amanda J Oliver, Ashleigh S Davey, Simon P Keam, Sherly Mardiana, Jack D Chan, Bianca von Scheidt, Paul A Beavis, Imran G House, Jonas RM Van Audernaerde, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

OBJECTIVES: Investigation of variable response rates to cancer immunotherapies has exposed the immunosuppressive tumor microenviro..

Switching on the green light for chimeric antigen receptor T-cell therapy

Sherly Mardiana, Junyun Lai, Imran Geoffrey House, Paul Andrew Beavis, Phillip Kevin Darcy

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Adoptive cellular therapy involving genetic modification of T cells with chimeric antigen receptor (CAR) transgene offers a promis..