Aya Taki

Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations

Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis

Journal article  |  2023  |  JOURNAL OF NATURAL PRODUCTS

The known Eremophila microtheca-derived diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid (1) was targeted for large-scale pu..

Using UHPLC-MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

Sasha Hayes, Aya C Taki, Kah Yean Lum, Joseph J Byrne, Merrick G Ekins, Robin B Gasser, Rohan A Davis

Journal article  |  2022  |  BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

In order to further expand the NatureBank open access compound library, chemical investigations of the Australian marine sponge, I..

Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

Aya CC Taki, Tao Wang, Nghi NN Nguyen, Ching-Seng Ang, Michael GG Leeming, Shuai Nie, Joseph JJ Byrne, Neil DD Young, Yuanting Zheng, Guangxu Ma, Pasi KK Korhonen, Anson VV Koehler, Nicholas AA Williamson, Andreas Hofmann, Bill CH Chang, Cecile Haeberli, Jennifer Keiser, Abdul Jabbar, Brad EE Sleebs, Robin BB Gasser

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. T..

Targeted Isolation of Antibiotic Brominated Alkaloids from the Marine Sponge Pseudoceratina durissima Using Virtual Screening and Molecular Networking

James Lever, Florian Kreuder, Jason Henry, Andrew Hung, Pierre-Marie Allard, Robert Brkljaca, Colin Rix, Aya C Taki, Robin B Gasser, Jan Kaslin, Donald Wlodkowic, Jean-Luc Wolfender, Sylvia Urban

Journal article  |  2022  |  MARINE DRUGS

Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity information to inform the strategy ..

Identification of Anthelmintic Bishomoscalarane Sesterterpenes from the Australian Marine Sponge Phyllospongia bergquistae and Structure Revision of Phyllolactones A-D

Sasha Hayes, Aya C Taki, Kah Yean Lum, Joseph J Byrne, Jonathan M White, Merrick G Ekins, Robin B Gasser, Rohan A Davis

Journal article  |  2022  |  JOURNAL OF NATURAL PRODUCTS

High-throughput screening of the NatureBank marine extract library (7616 samples) identified an extract derived from the Australia..

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

Anthony Marchand, Joyce WM Van Bree, Aya C Taki, Mati Moyat, Gerardo Turcatti, Marc Chambon, Adam Alexander Thil Smith, Rory Doolan, Robin B Gasser, Nicola Laraine Harris, Tiffany Bouchery

Journal article  |  2022  |  PHARMACEUTICALS

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in ..

The first reptilian allergen and major allergen for fish-allergic patients: Crocodile beta-parvalbumin

Thimo Ruethers, Roni Nugraha, Aya C Taki, Andrea O'Malley, Shaymaviswanathan Karnaneedi, Stephanie Zhang, A Brenda Kapingidza, Sam Mehr, Sandip D Kamath, Maksymilian Chruszcz, Graham Mackay, Dianne E Campbell, Andreas L Lopata

Journal article  |  2022  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

BACKGROUND: Clinical cross-reactivity between bony fish, cartilaginous fish, frog, and chicken muscle has previously been demonstr..

Whole-organism phenotypic screening methods used in early-phase anthelmintic drug discovery

HMP Dilrukshi Herath, Aya C Taki, Ali Rostami, Abdul Jabbar, Jennifer Keiser, Timothy G Geary, Robin B Gasser

Journal article  |  2022  |  BIOTECHNOLOGY ADVANCES

Diseases caused by parasitic helminths (worms) represent a major global health burden in both humans and animals. As vaccines agai..

The Algal Polysaccharide Ulvan and Carotenoid Astaxanthin Both Positively Modulate Gut Microbiota in Mice

Kunal Pratap, Marwan E Majzoub, Aya C Taki, Socorro Miranda Hernandez, Marie Magnusson, Christopher RK Glasson, Rocky de Nys, Torsten Thomas, Andreas L Lopata, Sandip D Kamath

Journal article  |  2022  |  FOODS

The intestinal microbial community (microbiota) is dynamic and variable amongst individuals and plays an essential part in gut hea..

Recombinant Tropomyosin from the Pacific Oyster (Crassostrea gigas) for Better Diagnosis

Roni Nugraha, Thimo Ruethers, Aya C Taki, Elecia B Johnston, Shaymaviswanathan Karnaneedi, Sandip D Kamath, Andreas L Lopata

Journal article  |  2022  |  FOODS

The Pacific oyster is a commercially important mollusc and, in contrast to most other shellfish species, frequently consumed witho..