Margaret Littlejohn

Secreted hepatitis B virus splice variants differ by HBV genotype and across phases of chronic hepatitis B infection

Olivia Maslac, Josef Wagner, Vitina Sozzi, Hugh Mason, Jenny Svarovskaia, Susanna Tan, Anuj Gaggar, Stephen Locarnini, Lilly Yuen, Margaret Littlejohn, Peter A Revill

Journal article  |  2022  |  JOURNAL OF VIRAL HEPATITIS

Chronic hepatitis B (CHB) is characterized by progression through different phases of hepatitis B virus (HBV) infection and diseas..

Evaluation of dried blood spots for hepatitis B and D serology and nucleic acid testing

Kathy Jackson, Thomas Holgate, Rosemary Tekoaua, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini

Journal article  |  2022  |  JOURNAL OF MEDICAL VIROLOGY

Areas with the highest burden of hepatitis B virus (HBV) infection are often low-middle-income countries with limited access to di..

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert

Journal article  |  2021  |  CELL DEATH & DISEASE

A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..

Analysis of Hepatitis B Virus Haplotype Diversity Detects Striking Sequence Conservation Across Genotypes and Chronic Disease Phase

Josef Wagner, Lilly Yuen, Margaret Littlejohn, Vitina Sozzi, Kathy Jackson, Vithika Suri, Susanna Tan, Becket Feierbach, Anuj Gaggar, Patrick Marcellin, Maria Buti Ferret, Harry LA Janssen, Ed Gane, Henry LY Chan, Danni Colledge, Gillian Rosenberg, Julianne Bayliss, Benjamin P Howden, Stephen A Locarnini, Darren Wong, et al.

Journal article  |  2021  |  HEPATOLOGY

BACKGROUND AND AIMS: We conducted haplotype analysis of complete hepatitis B virus (HBV) genomes following deep sequencing from 36..

Long-Term TDF-Inclusive ART and Progressive Rates of HBsAg Loss in HIV-HBV Coinfection-Lessons for Functional HBV Cure?

Jennifer Audsley, Anchalee Avihingsanon, Margaret Littlejohn, Scott Bowden, Gail Matthews, Christopher K Fairley, Sharon R Lewin, Joe Sasadeusz

Journal article  |  2020  |  JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

BACKGROUND: Tenofovir disoproxil fumarate (TDF) is effective in suppressing HIV and hepatitis B virus (HBV) replication in HIV-HBV..

Hepatitis B and D in the Pacific Islands of Kiribati

Kathy Jackson, Rosemary Tekoaua, Thomas Holgate, Ros Edwards, Lilly Yuen, Alice Lee, Suellen Nicholson, Margaret Littlejohn, Stephen Locarnini, Kabiri Tuneti

Journal article  |  2020  |  JOURNAL OF CLINICAL VIROLOGY

BACKGROUND: Historical reports indicate that hepatitis B and hepatitis D are highly endemic in the Pacific Island of Kiribati but ..

HBV variants are common in the 'immune-tolerant' phase of chronic hepatitis B

Lilly Yuen, Peter A Revill, Gillian Rosenberg, Josef Wagner, Margaret Littlejohn, Julianne Bayliss, Kathy Jackson, Susanna K Tan, Anuj Gaggar, Kathryn Kitrinos, Mani Subramanian, Ed Gane, Henry LY Chan, Xin Li, Scott Bowden, Stephen Locarnini, Alexander Thompson

Journal article  |  2020  |  JOURNAL OF VIRAL HEPATITIS

Nucleos(t)ide analogues (NUC) treatment prevents progression of liver fibrosis in subjects with chronic hepatitis B (CHB). However..

The evolution and clinical impact of hepatitis B virus genome diversity

Peter A Revill, Thomas Tu, Hans J Netter, Lilly KW Yuen, Stephen A Locarnini, Margaret Littlejohn

Journal article  |  2020  |  NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

The global burden of hepatitis B virus (HBV) is enormous, with 257 million persons chronically infected, resulting in more than 88..

Analysis of genomic-length HBV sequences to determine genotype and subgenotype reference sequences

Anna L McNaughton, Peter A Revill, Margaret Littlejohn, Philippa C Matthews, M Azim Ansari

Journal article  |  2020  |  JOURNAL OF GENERAL VIROLOGY

Hepatitis B virus (HBV) is a diverse, partially double-stranded DNA virus, with 9 genotypes (A-I), and a putative 10th genotype (J..

Point of care and oral fluid hepatitis B testing in remote Indigenous communities of northern Australia

Richard P Sullivan, Jane Davies, Paula Binks, Roslyn Gundjirryiir Dhurrkay, George Garambaka Gurruwiwi, Sarah Mariyalawuy Bukulatjpi, Melita McKinnon, Kelly Hosking, Margaret Littlejohn, Kathy Jackson, Stephen Locarnini, Joshua S Davis, Steven YC Tong

Journal article  |  2019  |  JOURNAL OF VIRAL HEPATITIS

Many Indigenous Australians in northern Australia living with chronic hepatitis B are unaware of their diagnosis due to low screen..