Garron Dodd

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman

Journal article  |  2020  |  eLife

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it cau..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  Molecular Metabolism

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  The EMBO Journal

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Garron T Dodd, Chrysovalantou E Xirouchaki, Matthew Eramo, Christina A Mitchell, Zane B Andrews, Belinda A Henry, Michael A Cowley, Tony Tiganis

Journal article  |  2019  |  Cell Reports

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Eglantine Balland, Weiyi Chen, Garron T Dodd, Gregory Conductier, Roberto Coppari, Tony Tiganis, Michael A Cowley

Journal article  |  2019  |  Cell Reports

Insulin action in the hypothalamus results in the suppression of hepatic glucose production (HGP). Obesity is often associated wit..

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Eleni Kyriakou, Stefanie Schmidt, Garron T Dodd, Katrin Pfuhlmann, Stephanie E Simonds, Dominik Lenhart, Arie Geerlof, Sonja C Schriever, Meri De Angelis, Karl-Werner Schramm, Oliver Plettenburg, Michael A Cowley, Tony Tiganis, Matthias H Tschoep, Paul T Pfluger, Michael Sattler, Ana C Messias

Journal article  |  2018  |  Journal of Medicinal Chemistry

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Marcus Grohmann, Florian Wiede, Garron T Dodd, Esteban N Gurzov, Geraldine J Ooi, Tariq Butt, Aliki A Rasmiena, Supreet Kaur, Twishi Gulati, Pei K Goh, Aislinn E Treloar, Stuart Archer, Wendy A Brown, Mathias Muller, Matthew J Watt, Osamu Ohara, Catriona A McLean, Tony Tiganis

Journal article  |  2018  |  Cell

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens Claus Bruening, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Horvath, David Spanswick, Tony Tiganis

Journal article  |  2018  |  eLife

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

Garron T Dodd, Robert S Lee-Young, Jens C Bruening, Tony Tiganis

Journal article  |  2018  |  Diabetes

Insulin regulates glucose metabolism by eliciting effects on peripheral tissues as well as the brain. Insulin receptor (IR) signal..