Garron Dodd

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

Cait A Beddows, Garron T Dodd

Journal article  |  2021  |  JOURNAL OF NEUROENDOCRINOLOGY

Insulin signals to the brain where it coordinates multiple physiological processes underlying energy and glucose homeostasis. This..

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Garron T Dodd, Seung Jae Kim, Mathieu Mequinion, Chrysovalantou E Xirouchaki, Jens C Bruening, Zane B Andrews, Tony Tiganis

Journal article  |  2021  |  SCIENCE ADVANCES

The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on..

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Amy A Worth, Rosemary Shoop, Katie Tye, Claire H Feetham, Giuseppe D'Agostino, Garron T Dodd, Frank Reimann, Fiona M Gribble, Emily C Beebe, James D Dunbar, Jesline T Alexander-Chacko, Dana K Sindelar, Tamer Coskun, Paul J Emmerson, Simon M Luckman

Journal article  |  2020  |  ELIFE

The cytokine, GDF15, is produced in pathological states which cause cellular stress, including cancer. When over expressed, it cau..

A Neural basis for Octanoic acid regulation of energy balance

Vanessa R Haynes, Natalie J Michael, Marco van den Top, Fei-Yue Zhao, Russell D Brown, David De Souza, Garron T Dodd, David Spanswick, Matthew J Watt

Journal article  |  2020  |  MOLECULAR METABOLISM

OBJECTIVES: Nutrient sensing by hypothalamic neurons is critical for the regulation of food intake and energy expenditure. We aime..

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron T Dodd, Pei K Goh, Conor Kearney, Deborah Meyran, Paul A Beavis, Melissa A Henderson, Simone L Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip K Darcy, Tony Tiganis

Journal article  |  2020  |  EMBO JOURNAL

Although adoptive T-cell therapy has shown remarkable clinical efficacy in haematological malignancies, its success in combating s..

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Garron T Dodd, Chrysovalantou E Xirouchaki, Matthew Eramo, Christina A Mitchell, Zane B Andrews, Belinda A Henry, Michael A Cowley, Tony Tiganis

Journal article  |  2019  |  CELL REPORTS

The importance of hypothalamic leptin and insulin resistance in the development and maintenance of obesity remains unclear. The ty..

PTPN2 deletion in T cells promotes anti-tumour immunity and CAR T cell efficacy in solid tumours

Florian Wiede, Kun-Hui Lu, Xin Du, Shuwei Liang, Katharina Hochheiser, Garron Dodd, Pei Goh, Conor Kearney, Deborah Meyran, Paul Beavis, Melissa Henderson, Simone Park, Jason Waithman, Sheng Zhang, Zhong-Yin Zhang, Jane Oliaro, Thomas Gebhardt, Phillip Darcy, Tony Tiganis

Journal article  |  2019

ABSTRACT Although adoptive T cell therapy has shown remarkable clinical efficacy in hematological malignancies, its success in com..

Persistent leptin signalling in the arcuate nucleus reduces insulin's capacity to suppress hepatic glucose production in obese mice

Eglantine Balland, Weiyi Chen, Garron Dodd, Gregory Conductier, Tony Tiganis, Michael A Cowley

Journal article  |  2019  |  Obesity Research & Clinical Practice

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Garron T Dodd, Natalie J Michael, Robert S Lee-Young, Salvatore P Mangiafico, Jack T Pryor, Astrid C Munder, Stephanie E Simonds, Jens C Brüning, Zhong-Yin Zhang, Michael A Cowley, Sofianos Andrikopoulos, Tamas L Hovarth, David Spanswick, Tony Tiganis

Journal article  |  2019  |  Obesity Research & Clinical Practice