Ric De Paoli-Iseppi

Long-Read RNA Sequencing Identifies Polyadenylation Elongation and Differential Transcript Usage of Host Transcripts During SARS-CoV-2 In Vitro Infection

Jessie J-Y Chang, Josie Gleeson, Daniel Rawlinson, Ricardo De Paoli-Iseppi, Chenxi Zhou, Francesca L Mordant, Sarah L Londrigan, Michael B Clark, Kanta Subbarao, Timothy P Stinear, Lachlan JM Coin, Miranda E Pitt

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Better methods to interrogate host-pathogen interactions during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infec..

Using long-read RNA sequencing to decipher the role of RNA isoforms in disease

Ricardo De Paoli-Iseppi, Shweta Joshi, Tomasz Wrzesinski, Paul J Harrison, Wilfried Haerty, Elizabeth M Tunbridge, Michael B Clark

Journal article  |  2022  |  Pathology

Accurate quantification of genes and their mRNA products is essential to understanding health and disease. In humans, processes su..

Isoform Age-Splice Isoform Profiling Using Long-Read Technologies (vol 8, 744, 2021)

Ricardo De Paoli-Iseppi, Josie Gleeson, Michael B Clark

Journal article  |  2021  |  FRONTIERS IN MOLECULAR BIOSCIENCES

[This corrects the article DOI: 10.3389/fmolb.2021.711733.].

The long and the short of it: unlocking nanopore long-read RNA sequencing data with short-read differential expression analysis tools

Xueyi Dong, Luyi Tian, Quentin Gouil, Hasaru Kariyawasam, Shian Su, Ricardo De Paoli-Iseppi, Yair David Joseph Prawer, Michael B Clark, Kelsey Breslin, Megan Iminitoff, Marnie E Blewitt, Charity W Law, Matthew E Ritchie

Journal article  |  2021  |  NAR Genomics and Bioinformatics

Application of Oxford Nanopore Technologies' long-read sequencing platform to transcriptomic analysis is increasing in popularity...

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

Jessie J-Y Chang, Daniel Rawlinson, Miranda E Pitt, George Taiaroa, Josie Gleeson, Chenxi Zhou, Francesca L Mordant, Ricardo De Paoli-Iseppi, Leon Caly, Damian FJ Purcell, Timothy P Stinear, Sarah L Londrigan, Michael B Clark, Deborah A Williamson, Kanta Subbarao, Lachlan JM Coin

Journal article  |  2021  |  CELL REPORTS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses subgenomic RNA (sgRNA) to produce viral proteins for replication..

Multiomic analysis elucidates Complex I deficiency caused by a deep intronic variant in NDUFB10

Guy Helman, Alison G Compton, Daniella H Hock, Marzena Walkiewicz, Gemma R Brett, Lynn Pais, Tiong Y Tan, Ricardo De Paoli-Iseppi, Michael B Clark, John Christodoulou, Susan M White, David R Thorburn, David A Stroud, Zornitza Stark, Cas Simons

Journal article  |  2020  |  HUMAN MUTATION

The diagnosis of Mendelian disorders following uninformative exome and genome sequencing remains a challenging and often unmet nee..

Pan-cancer analysis of whole genomes

Peter J Campbell, Gad Getz, Jan O Korbel, Joshua M Stuart, Jennifer L Jennings, Lincoln D Stein, Marc D Perry, Hardeep K Nahal-Bose, BF Francis Ouellette, Constance H Li, Esther Rheinbay, G Petur Nielsen, Dennis C Sgroi, Chin-Lee Wu, William C Faquin, Vikram Deshpande, Paul C Boutros, Alexander J Lazar, Katherine A Hoadley, David N Louis, et al.

Journal article  |  2020  |  NATURE

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this v..

Age estimation in a long-lived seabird (Ardenna tenuirostris) using DNA methylation-based biomarkers

Ricardo De Paoli-Iseppi, Bruce E Deagle, Andrea M Polanowski, Clive R McMahon, Joanne L Dickinson, Mark A Hindell, Simon N Jarman

Journal article  |  2019  |  MOLECULAR ECOLOGY RESOURCES

Age structure is a fundamental aspect of animal population biology. Age is strongly related to individual physiological condition,..

Multiple endocrine neoplasia type 1: clinical correlates of MEN1 gene methylation

Ricardo De Paoli-Iseppi, Louise Prentice, James R Marthick, Russell Thomson, Adele F Holloway, Joanne L Dickinson, John Burgess

Journal article  |  2018  |  Pathology

Multiple endocrine neoplasia type 1 (MEN 1) has marked severity variation between individuals with the same mutation. To investiga..

DNA methylation levels in candidate genes associated with chronological age in mammals are not conserved in a long-lived seabird

Ricardo De Paoli-Iseppi, Andrea M Polanowski, Clive McMahon, Bruce E Deagle, Joanne L Dickinson, Mark A Hindell, Simon N Jarman

Journal article  |  2017  |  PLOS ONE

Most seabirds do not have any outward identifiers of their chronological age, so estimation of seabird population age structure ge..