Alan Hayes

The Paradoxical Effect of PARP Inhibitor BGP-15 on Irinotecan-Induced Cachexia and Skeletal Muscle Dysfunction

Dean G Campelj, Cara A Timpani, Aaron C Petersen, Alan Hayes, Craig A Goodman, Emma Rybalka

Journal article  |  2020  |  Cancers

Chemotherapy-induced muscle wasting and dysfunction is a contributing factor to cachexia alongside cancer and increases the risk o..

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

Emma Rybalka, Cara A Timpani, Danielle A Debruin, Ryan M Bagaric, Dean G Campelj, Alan Hayes

Journal article  |  2020  |  Cells

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for th..

Undercarboxylated osteocalcin is associated with vascular function in female older adults but does not influence vascular function in male rabbit carotid artery ex vivo

Alexander Tacey, Cassandra Smith, Mary N Woessner, Paul Chubb, Christopher Neil, Gustavo Duque, Alan Hayes, Anthony Zulli, Itamar Levinger

Journal article  |  2020  |  PLOS ONE

BACKGROUND: There are conflicting reports on the association of undercarboxylated osteocalcin (ucOC) in cardiovascular disease dev..

The Failed Clinical Story of Myostatin Inhibitors Against Duchenne Muscular Dystrophy: Exploring the Biology Behind the Battle

Emma Rybalka, Cara Timpani, Danielle Debruin, Ryan Bagaric, Dean Campelj, Alan Hayes

Journal article  |  2020

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for th..

Muscle fibre morphometry in winnie mice model of inflammatory bowel disease

S Sharma, K Nurgali, D Debruin, A Hayes, G Duque

Conference Proceedings  |  2020  |  AUSTRALASIAN JOURNAL ON AGEING

Associations of Sarcopenia Components With Physical Activity and Nutrition in Australian Older Adults Performing Exercise Training

Ewelina Akehurst, David Scott, Juan Peña Rodriguez, Carol Alonso Gonzalez, Jasmaine Alyce Murphy, Helen McCarthy, Sandor Dorgo, Alan Hayes

Journal article  |  2020

Abstract Background: The risk of progressive declines in skeletal muscle mass and strength, termed sarcopenia, increases with age,..

Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice.

Dean G Campelj, Danielle A Debruin, Cara A Timpani, Alan Hayes, Craig A Goodman, Emma Rybalka

Journal article  |  2020  |  Scientific Reports

The purpose of this study was to determine whether (1) sodium nitrate (SN) treatment progressed or alleviated doxorubicin (DOX)-in..

Education, occupation and operational measures of sarcopenia: Six years of australian data

Sharon L Brennan-Olsen, Sara Vogrin, Saliu Balogun, Feitong Wu, David Scott, Graeme Jones, Alan Hayes, Steven Phu, Gustavo Duque, Alison Beauchamp, Jason Talevski, Ghazala Naureen, Tania M Winzenberg

Journal article  |  2020  |  Australasian Journal on Ageing

Undercarboxylated osteocalcin has no adverse effect on endothelial function in rabbit aorta or human vascular cells

Alexander Tacey, Sophie Millar, Tawar Qaradakhi, Cassandra Smith, Alan Hayes, Susan Anderson, Anthony Zulli, Saoirse O'Sullivan, Itamar Levinger

Journal article  |  2020  |  Journal of Cellular Physiology

Undercarboxylated osteocalcin (ucOC) improves glucose metabolism; however, its effects on endothelial cell function are unclear. W..

Prevalence of sarcopenia and associations of sarcopenia components with physical function and health-related quality of life in Australian older adults performing exercise training

Ewelina Akehurst, David Scott, Juan Peña Rodriguez, Carol Alonso Gonzalez, Jasmaine Murphy, Sandor Dorgo, Alan Hayes

Journal article  |  2020

Abstract Background Sarcopenia can be prevented and treated with exercise, particularly resistance training. Our aim was to explo..