Ben Parker

Tumor-derived MMPs regulate cachexia in a Drosophila cancer model.

William Lodge, Michael Zavortink, Sofia Golenkina, Francesca Froldi, Callum Dark, Shane Cheung, Benjamin L Parker, Ronnie Blazev, Daniel Bakopoulos, Elizabeth L Christie, Verena C Wimmer, Brigette C Duckworth, Helena E Richardson, Louise Y Cheng

Journal article  |  2021  |  Dev Cell

Cachexia, the wasting syndrome commonly observed in advanced cancer patients, accounts for up to one-third of cancer-related morta..

Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis

Geraldine J Ooi, Peter J Meikle, Kevin Huynh, Wendy Brown, Paul Burton, Matthew J Watt

Journal article  |  2021  |  JOURNAL OF HEPATOLOGY

BACKGROUNDS & AIMS: Obesity often leads to non-alcoholic fatty liver disease (NAFLD), which can progress from simple steatosis (no..

CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data

Jeffrey Molendijk, Marcus M Seldin, Benjamin L Parker

Journal article  |  2021  |  NUCLEIC ACIDS RESEARCH

The integration of genomics, transcriptomics, proteomics and phenotypic traits across genetically diverse populations is a powerfu..

Western Diet Induced Remodelling of the Tongue Proteome

Mriga Dutt, Yaan-Kit Ng, Jeffrey Molendijk, Hamzeh Karimkhanloo, Luoping Liao, Ronnie Blazev, Magdalene K Montgomery, Matthew J Watt, Benjamin L Parker

Journal article  |  2021  |  PROTEOMES

The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and d..

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K Watt, DC Henstridge, M Ziemann, CB Sim, MK Montgomery, D Samocha-Bonet, BL Parker, GT Dodd, ST Bond, TM Salmi, RS Lee, RE Thomson, A Hagg, JR Davey, H Qian, R Koopman, A El-Osta, JR Greenfield, MJ Watt, MA Febbraio, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strat..

Sulfotyrosine-Mediated Recognition of Human Thrombin by a Tsetse Fly Anticoagulant Mimics Physiological Substrates

Barbara M Calisto, Jorge Ripoll-Rozada, Luke J Dowman, Charlotte Franck, Stijn M Agten, Benjamin L Parker, Rita Carvalho Veloso, Nuno Vale, Paula Gomes, Daniele de Sanctis, Richard J Payne, Pedro Jose Barbosa Pereira

Journal article  |  2021  |  CELL CHEMICAL BIOLOGY

Despite possessing only 32 residues, the tsetse thrombin inhibitor (TTI) is among the most potent anticoagulants described, with s..

Proteome-wide Systems Genetics to Identify Functional Regulators of Complex Traits

Jeffrey Molendijk, Benjamin L Parker

Journal article  |  2021  |  CELL SYSTEMS

Proteomic technologies now enable the rapid quantification of thousands of proteins across genetically diverse samples. Integratio..

Dynamic Changes to the Skeletal Muscle Proteome and Ubiquitinome Induced by the E3 Ligase, ASB2 beta

Craig A Goodman, Jonathan R Davey, Adam Hagg, Benjamin L Parker, Paul Gregorevic

Journal article  |  2021  |  MOLECULAR & CELLULAR PROTEOMICS

Ubiquitination is a posttranslational protein modification that has been shown to have a range of effects, including regulation of..

Hyper-truncated Asn355-and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase

Harry C Tjondro, Julian Ugonotti, Rebeca Kawahara, Sayantani Chatterjee, Ian Loke, Siyun Chen, Fabian Soltermann, Hannes Hinneburg, Benjamin L Parker, Vignesh Venkatakrishnan, Regis Dieckmann, Oliver C Grant, Johan Bylund, Alison Rodger, Robert J Woods, Anna Karlsson-Bengtsson, Weston B Struwe, Morten Thaysen-Andersen

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloperoxidase (MPO) plays essential roles in neutrophil-mediated immunity via the generation of reactive oxidation products. Com..

Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development

Ronnie Blazev, Christopher Ashwood, Jodie L Abrahams, Long H Chung, Deanne Francis, Pengyi Yang, Kevin Watt, Hongwei Qian, Gregory A Quaife-Ryan, James E Hudson, Paul Gregorevic, Morten Thaysen-Andersen, Benjamin L Parker

Journal article  |  2021  |  MOLECULAR & CELLULAR PROTEOMICS

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the develo..