Ben Parker

Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle

James W McNamara, Benjamin L Parker, Holly K Voges, Neda R Mehdiabadi, Francesca Bolk, Feroz Ahmad, Jin D Chung, Natalie Charitakis, Jeffrey Molendijk, Antonia TL Zech, Sean Lal, Mirana Ramialison, Kathy Karavendzas, Hayley L Pointer, Petros Syrris, Luis R Lopes, Perry M Elliott, Gordon S Lynch, Richard J Mills, James E Hudson, et al.

Journal article  |  2023  |  Nature Cardiovascular Research

AbstractMuscle contraction is driven by the molecular machinery of the sarcomere. As phosphorylation is a critical regulator of mu..

Glycomics-Assisted Glycoproteomics Enables Deep and Unbiased N-Glycoproteome Profiling of Complex Biological Specimens.

The Huong Chau, Anastasia Chernykh, Julian Ugonotti, Benjamin L Parker, Rebeca Kawahara, Morten Thaysen-Andersen

Journal article  |  2023  |  Methods Mol Biol

Mass spectrometry-driven glycomics and glycoproteomics, the system-wide profiling of detached glycans and intact glycopeptides fro..

Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function

Jeffrey Molendijk, Ronnie Blazev, Richard J Mills, Yaan-Kit Ng, Kevin Watt, Daryn Chau, Paul Gregorevic, Peter J Crouch, James BW Hilton, Leszek Lisowski, Peixiang Zhang, Karen Reue, Aldons J Lusis, James E Hudson, David E James, Marcus M Seldin, Benjamin L Parker

Journal article  |  2022  |  ELIFE

Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle meta..

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.

Michael Papanicolaou, Amelia L Parker, Michelle Yam, Elysse C Filipe, Sunny Z Wu, Jessica L Chitty, Kaitlin Wyllie, Emmi Tran, Ellie Mok, Audrey Nadalini, Joanna N Skhinas, Morghan C Lucas, David Herrmann, Max Nobis, Brooke A Pereira, Andrew MK Law, Lesley Castillo, Kendelle J Murphy, Anaiis Zaratzian, Jordan F Hastings, et al.

Journal article  |  2022  |  Nat Commun

The tumour stroma, and in particular the extracellular matrix (ECM), is a salient feature of solid tumours that plays a crucial ro..

urPTMdb/TeaProt: Upstream and Downstream Proteomics Analysis

Jeffrey Molendijk, Rui Yip, Benjamin L Parker

Journal article  |  2022  |  JOURNAL OF PROTEOME RESEARCH

We have developed the underrepresented post-translational modification (PTM) database (urPTMdb), a PTM gene set database to accele..

Glycoproteomics

Ieva Bagdonaite, Stacy A Malaker, Daniel A Polasky, Nicholas M Riley, Katrine Schjoldager, Sergey Y Vakhrushev, Adnan Halim, Kiyoko F Aoki-Kinoshita, Alexey I Nesvizhskii, Carolyn R Bertozzi, Hans H Wandall, Benjamin L Parker, Morten Thaysen-Andersen, Nichollas E Scott

Journal article  |  2022  |  NATURE REVIEWS METHODS PRIMERS

Protein glycosylation involves the co-translational or post-translational addition of glycans to proteins and is a crucial protein..

SILAC kinase screen identifies potential MASTL substrates.

Kamila A Marzec, Samuel Rogers, Rachael McCloy, Benjamin L Parker, David E James, D Neil Watkins, Andrew Burgess

Journal article  |  2022  |  Sci Rep

Microtubule-associated serine/threonine kinase-like (MASTL) has emerged as a critical regulator of mitosis and as a potential onco..

Time-resolved phosphoproteome and proteome analysis reveals kinase signaling on master transcription factors during myogenesis.

Di Xiao, Marissa Caldow, Hani Jieun Kim, Ronnie Blazev, Rene Koopman, Deborah Manandi, Benjamin L Parker, Pengyi Yang

Journal article  |  2022  |  iScience

Myogenesis is governed by signaling networks that are tightly regulated in a time-dependent manner. Although different protein kin..

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.

Xiaowen Duan, Dougall M Norris, Sean J Humphrey, Pengyi Yang, Kristen C Cooke, Will P Bultitude, Benjamin L Parker, Olivia J Conway, James G Burchfield, James R Krycer, Frances M Brodsky, David E James, Daniel J Fazakerley

Journal article  |  2022  |  Biochem J

Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4 trafficking and insulin sensitivity. Howev..