Keith Martin

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Veselina Petrova, Craig S Pearson, Jared Ching, James R Tribble, Andrea G Solano, Yunfei Yang, Fiona M Love, Robert J Watt, Andrew Osborne, Evan Reid, Pete A Williams, Keith R Martin, Herbert M Geller, Richard Eva, James W Fawcett

Journal article  |  2020  |  Nature Communications

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequ..

Aqueous outflow imaging techniques and what they tell us about intraocular pressure regulation

Jed A Lusthaus, Tasneem Z Khatib, Paul AR Meyer, Peter McCluskey, Keith R Martin

Journal article  |  2020  |  Eye

PI3-kinase delta enhances axonalPIP(3)to support axon regeneration in the adultCNS

Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench-Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, et al.

Journal article  |  2020  |  EMBO Molecular Medicine

The Effects of Trabecular Bypass Surgery on Conventional Aqueous Outflow, Visualized by Hemoglobin Video Imaging

Jed A Lusthaus, Paul AR Meyer, Tasneem Z Khatib, Keith R Martin

Journal article  |  2020  |  Journal of Glaucoma

PRECIS: Hemoglobin Video Imaging (HVI) provides a noninvasive method to quantify aqueous outflow (AO) perioperatively. Trabecular ..

Improvement in inner retinal function in glaucoma with nicotinamide (vitaminB3) supplementation: A crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete A Williams, Myra B McGuinness, Xavier Hadoux, Robert J Casson, Michael Coote, Ian A Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan G Crowston

Journal article  |  2020  |  Clinical and Experimental Ophthalmology

IMPORTANCE: Retinal ganglion cells endure significant metabolic stress in glaucoma but maintain capacity to recover function. Nico..

Neuronal Reprogramming for Tissue Repair and Neuroregeneration

Roxanne Hsiang-Chi Liou, Thomas L Edwards, Keith R Martin, Raymond Ching-Bong Wong

Journal article  |  2020  |  International Journal of Molecular Sciences

Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural r..

Selective laser trabeculoplasty versus topical medication as initial glaucoma treatment: the glaucoma initial treatment study randomised clinical trial

Ghee Soon Ang, Eva K Fenwick, Marios Constantinou, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Robert J Casson, Eric A Finkelstein, Ivan Goldberg, Paul R Healey, Konrad Pesudovs, Sutha Sanmugasundram, Jing Xie, Rachel McIntosh, Jonathan Jackson, Anthony Wells, Andrew White, Keith Martin, Mark J Walland, Jonathan G Crowston, Ecosse Luc Lamoureux

Journal article  |  2020  |  British Journal of Ophthalmology

BACKGROUND/AIMS: To determine if selective laser trabeculoplasty (SLT) is superior to topical medication as a first-line treatment..

Neutralising antibody responses to intravitreally delivered AAV2 and exosome-associated AAV2 vectors are associated with a failure of repeated gene transfer following vector readministration in the ipsilateral eye

Michael Whitehead, Andrew Osborne, Peter Widdowson, Patrick Yu-Wai-Man, Keith R Martin

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete Williams, Myra McGuinness, Xavier Hadoux, Robert James Casson, Michael Coote, Ian Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan Guy Crowston

Conference Proceedings  |  2020  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Importance: Retinal ganglion cells endure significant metabolic stress with ageing and glaucoma-related stressors. Injured cells r..

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error

Qiao Fan, Alfred Pozarickij, Nicholas YQ Tan, Xiaobo Guo, Virginie JM Verhoeven, Veronique Vitart, Jeremy A Guggenheim, Masahiro Miyake, J Willem L Tideman, Anthony P Khawaja, Liang Zhang, Stuart MacGregor, Rene Hoehn, Peng Chen, Ginevra Biino, Juho Wedenoja, Seyed Ehsan Saffari, Milly S Tedja, Jing Xie, Carla Lanca, et al.

Journal article  |  2020  |  Communications Biology

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and b..