Keith Martin

Humoral immune responses to AAV gene therapy in the ocular compartment

Michael Whitehead, Andrew Osborne, Patrick Yu-Wai-Man, Keith Martin

Journal article  |  2021  |  BIOLOGICAL REVIEWS

Viral vectors can be utilised to deliver therapeutic genes to diseased cells. Adeno-associated virus (AAV) is a commonly used vira..

Evaluating multidisciplinary glaucoma care: visual field progression and loss of sight year analysis in the community vs hospital setting

Yusuf Mushtaq, Binita Panchasara, Nikou Nassehzadehtabriz, Hong Kai Lim, Maryam Mushtaq, Jane Kean, Sarah Farrell, Rupert RA Bourne, Humma Shahid, Tasneem Z Khatib, Keith R Martin

Journal article  |  2021  |  EYE

BACKGROUND: A variety of shared care models have been developed, which aim to stratify glaucoma patients according to risk of dise..

Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery

Tasneem Z Khatib, Andrew Osborne, Sujeong Yang, Zara Ali, Wanyi Jia, Ilya Manyakin, Katie Hall, Robert Watt, Peter S Widdowson, Keith R Martin

Journal article  |  2021  |  SCIENCE ADVANCES

Gene replacement approaches are leading to a revolution in the treatment of previously debilitating monogenic neurological conditi..

Investigation of associations between retinal microvascular parameters and albuminuria in UK Biobank: a cross-sectional case-control study

Euan N Paterson, Chris Cardwell, Thomas J MacGillivray, Emanuele Trucco, Alexander S Doney, Paul Foster, Alexander P Maxwell, Gareth J McKay

Journal article  |  2021  |  BMC NEPHROLOGY

BACKGROUND: Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invas..

How to Reduce Error in Optic Nerve Head Examination

Craig Ross, George Kong, Keith R Martin, Michael A Coote

Book Chapter  |  2021

Getting Better: Learning, New Tools and Risk Management

Zhichao Wu, Michael A Coote, Keith R Martin

Book Chapter  |  2021

Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS

Veselina Petrova, Craig S Pearson, Jared Ching, James R Tribble, Andrea G Solano, Yunfei Yang, Fiona M Love, Robert J Watt, Andrew Osborne, Evan Reid, Pete A Williams, Keith R Martin, Herbert M Geller, Richard Eva, James W Fawcett

Journal article  |  2020  |  NATURE COMMUNICATIONS

Adult mammalian central nervous system axons have intrinsically poor regenerative capacity, so axonal injury has permanent consequ..

Aqueous outflow imaging techniques and what they tell us about intraocular pressure regulation

Jed A Lusthaus, Tasneem Z Khatib, Paul AR Meyer, Peter McCluskey, Keith R Martin

Journal article  |  2020  |  EYE

Recent advances in the medical and surgical management of open-angle glaucoma have increased the number of treatment options avail..

PI3-kinase delta enhances axonalPIP(3)to support axon regeneration in the adultCNS

Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench-Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, et al.

Journal article  |  2020  |  EMBO MOLECULAR MEDICINE

Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons los..

The Effects of Trabecular Bypass Surgery on Conventional Aqueous Outflow, Visualized by Hemoglobin Video Imaging

Jed A Lusthaus, Paul AR Meyer, Tasneem Z Khatib, Keith R Martin

Journal article  |  2020  |  JOURNAL OF GLAUCOMA

PRECIS: Hemoglobin Video Imaging (HVI) provides a noninvasive method to quantify aqueous outflow (AO) perioperatively. Trabecular ..