Daniel Clarke

Synthesis of Cholesterol Glycoconjugates for Targeted Liposomal Drug Delivery

H Nguyen, Y Pan, AA Nahain, D Clarke, NA McMillan, V Ferro

Journal article  |  2020  |  Trends in Carbohydrate Research

Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237.

Yaman Tayyar, Ryan Shiels, Andrew C Bulmer, Alfred K Lam, Daniel Clarke, Adi Idris, Nigel A McMillan

Journal article  |  2019  |  PLoS One

Human papilloma virus (HPV) is the main culprit in cervical cancers. Although the HPV vaccine is now available, the slow and gradu..

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage.

D Clarke, Adi Idris, Nigel McMillan

Journal article  |  2019  |  PLoS ONE

Liposomes are versatile and well-proven as a means to deliver nucleic acids into cells. Most of the formulation procedures used ar..

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

Mushfiq H Shaikh, Adi Idris, Newell W Johnson, Sora Fallaha, Daniel TW Clarke, David Martin, Iain M Morgan, Brian Gabrielli, Nigel AJ McMillan

Journal article  |  2018  |  ORAL ONCOLOGY

OBJECTIVES: Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Cu..

RNAi Targeting of Human Metapneumovirus P and N Genes Inhibits Viral Growth.

Kathleen Nitschinsk, Daniel Clarke, Adi Idris, Nigel McMillan

Journal article  |  2018  |  Intervirology

BACKGROUND/AIMS: Human metapneumovirus (hMPV) is an important human respiratory pathogen and is implicated in an array of respirat..

Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh

Mushfiq H Shaikh, Aminul I Khan, Anwar Sadat, Ahmed H Chowdhury, Shahed A Jinnah, Vinod Gopalan, Alfred K Lam, Daniel TW Clarke, Nigel AJ McMillan, Newell W Johnson

Journal article  |  2017  |  BMC CANCER

BACKGROUND: There is a dramatic rise in the incidence of Human papillomavirus (HPV) - associated head and neck squamous cell carci..

Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?

Mushfiq H Shaikh, Daniel TW Clarke, Newell W Johnson, Nigel AJ McMillan

Journal article  |  2017  |  ORAL ONCOLOGY

Conventional treatment strategies have done little to improve the prognosis or disease-free survival in head and neck cancer (HNC)..

MUC13 protects colorectal cancer cells from death by activating the NF-kappa B pathway and is a potential therapeutic target

YH Sheng, Y He, SZ Hasnain, R Wang, H Tong, DT Clarke, R Lourie, I Oancea, KY Wong, JW Lumley, TH Florin, P Sutton, JD Hooper, NA McMillan, MA McGuckin

Journal article  |  2017  |  ONCOGENE

MUC13 is a transmembrane mucin glycoprotein that is over produced by many cancers, although its functions are not fully understood..

Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Brian Gabrielli, Fawzi Bokhari, Max V Ranall, Zay Yar Oo, Alexander J Stevenson, Weili Wang, Melanie Murrell, Mushfiq Shaikh, Sora Fallaha, Daniel Clarke, Madison Kelly, Karin Sedelies, Melinda Christensen, Sara McKee, Graham Leggatt, Paul Leo, Dubravka Skalamera, H Peter Soyer, Thomas J Gonda, Nigel AJ McMillan

Journal article  |  2015  |  MOLECULAR CANCER THERAPEUTICS

Human papillomavirus (HPV) is the causative agent in cervical cancer. HPV oncogenes are major drivers of the transformed phenotype..

Targeted Drug Delivery to the Virus-Infected Airway; Complications and Remedies

Daniel TW Clarke, Nigel AJ McMillan

Journal article  |  2015  |  CURRENT DRUG DELIVERY

Drug delivery to the airway and lower respiratory tract by aerosol inhalation has become a successful, non-invasive method of prev..