Daniel Clarke

Synthesis of Cholesterol Glycoconjugates for Targeted Liposomal Drug Delivery

H Nguyen, Y Pan, AA Nahain, D Clarke, NA McMillan, V Ferro

Journal article  |  2020  |  Trends in Carbohydrate Research

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage.

D Clarke, Adi Idris, Nigel McMillan

Journal article  |  2019  |  PLoS ONE

Liposomes are versatile and well-proven as a means to deliver nucleic acids into cells. Most of the formulation procedures used ar..

Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237.

Yaman Tayyar, Ryan Shiels, Andrew C Bulmer, Alfred K Lam, Daniel Clarke, Adi Idris, Nigel A McMillan

Journal article  |  2019  |  PLoS One

Human papilloma virus (HPV) is the main culprit in cervical cancers. Although the HPV vaccine is now available, the slow and gradu..

Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers

Mushfiq H Shaikh, Adi Idris, Newell W Johnson, Sora Fallaha, Daniel TW Clarke, David Martin, Iain M Morgan, Brian Gabrielli, Nigel AJ McMillan

Journal article  |  2018  |  ORAL ONCOLOGY

OBJECTIVES: Human papilloma virus (HPV) is the main culprit in cancers of the cervix, penis, anus, skin, eye and head and neck. Cu..

RNAi Targeting of Human Metapneumovirus P and N Genes Inhibits Viral Growth.

Kathleen Nitschinsk, Daniel Clarke, Adi Idris, Nigel McMillan

Journal article  |  2018  |  Intervirology

BACKGROUND/AIMS: Human metapneumovirus (hMPV) is an important human respiratory pathogen and is implicated in an array of respirat..

Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh

Mushfiq H Shaikh, Aminul I Khan, Anwar Sadat, Ahmed H Chowdhury, Shahed A Jinnah, Vinod Gopalan, Alfred K Lam, Daniel TW Clarke, Nigel AJ McMillan, Newell W Johnson

Journal article  |  2017  |  BMC CANCER

BACKGROUND: There is a dramatic rise in the incidence of Human papillomavirus (HPV) - associated head and neck squamous cell carci..

Can gene editing and silencing technologies play a role in the treatment of head and neck cancer?

Mushfiq H Shaikh, Daniel TW Clarke, Newell W Johnson, Nigel AJ McMillan

Journal article  |  2017  |  ORAL ONCOLOGY

Conventional treatment strategies have done little to improve the prognosis or disease-free survival in head and neck cancer (HNC)..

MUC13 protects colorectal cancer cells from death by activating the NF-kappa B pathway and is a potential therapeutic target

YH Sheng, Y He, SZ Hasnain, R Wang, H Tong, DT Clarke, R Lourie, I Oancea, KY Wong, JW Lumley, TH Florin, P Sutton, JD Hooper, NA McMillan, MA McGuckin

Journal article  |  2017  |  ONCOGENE

MUC13 is a transmembrane mucin glycoprotein that is over produced by many cancers, although its functions are not fully understood..

Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer

Brian Gabrielli, Fawzi Bokhari, Max V Ranall, Zay Yar Oo, Alexander J Stevenson, Weili Wang, Melanie Murrell, Mushfiq Shaikh, Sora Fallaha, Daniel Clarke, Madison Kelly, Karin Sedelies, Melinda Christensen, Sara McKee, Graham Leggatt, Paul Leo, Dubravka Skalamera, H Peter Soyer, Thomas J Gonda, Nigel AJ McMillan

Journal article  |  2015  |  MOLECULAR CANCER THERAPEUTICS

Human papillomavirus (HPV) is the causative agent in cervical cancer. HPV oncogenes are major drivers of the transformed phenotype..

Targeted Drug Delivery to the Virus-Infected Airway; Complications and Remedies

Daniel TW Clarke, Nigel AJ McMillan

Journal article  |  2015  |  CURRENT DRUG DELIVERY

Drug delivery to the airway and lower respiratory tract by aerosol inhalation has become a successful, non-invasive method of prev..