Danielle Debruin

Lipid metabolism in sarcopenia

Ahmed Al Saedi, Danielle A Debruin, Alan Hayes, Mark Hamrick

Journal article  |  2022  |  BONE

Sarcopenia is an age-related disease associated with loss of muscle mass and strength. This geriatric syndrome predisposes elderly..

The importance of mitochondrial quality control for maintaining skeletal muscle function across health span

James Sligar, Danielle A DeBruin, Nicholas J Saner, Ashleigh M Philp, Andrew Philp

Journal article  |  2022  |  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

As the principal energy-producing organelles of the cell, mitochondria support numerous biological processes related to metabolism..

Winnie mice of spontaneous chronic colitis: a novel model to study sarcopenia in inflammatory bowel disease

Shilpa Sharma, Danielle Debruin, Kulmira Nurgali, Alan Hayes, Gustavo Duque

Conference Proceedings  |  2022  |  JOURNAL OF BONE AND MINERAL RESEARCH

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

Emma Rybalka, Cara A Timpani, Danielle A Debruin, Ryan M Bagaric, Dean G Campelj, Alan Hayes

Journal article  |  2020  |  CELLS

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for th..

Muscle fibre morphometry in winnie mice model of inflammatory bowel disease

S Sharma, K Nurgali, D Debruin, A Hayes, G Duque

Conference Proceedings  |  2020  |  AUSTRALASIAN JOURNAL ON AGEING

Evaluation of combining castration and hind-limb immobilisation to induce sarcopenia in mice

D Debruin, A Hayes

Conference Proceedings  |  2020  |  AUSTRALASIAN JOURNAL ON AGEING

Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice

Dean G Campelj, Danielle A Debruin, Cara A Timpani, Alan Hayes, Craig A Goodman, Emma Rybalka

Journal article  |  2020  |  SCIENTIFIC REPORTS

The purpose of this study was to determine whether (1) sodium nitrate (SN) treatment progressed or alleviated doxorubicin (DOX)-in..

Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice

Danielle A Debruin, Cara A Timpani, Hannah Lalunio, Emma Rybalka, Craig A Goodman, Alan Hayes

Journal article  |  2020  |  JOURNAL OF BONE AND MINERAL RESEARCH

Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements ha..

Winnie mice: A model to study sarcopenia concomitant with inflammation-induced colitis

Shilpa Sharma, Danielle Debruin, Rhiannon Flippone, Kulmira Nurgali, Alan Hayes, Gustavo Duque

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Aging Muscle and Sarcopenia

Ben Kirk, Steven Phu, Danielle A Debruin, Alan Hayes, Gustavo Duque

Book Chapter  |  2020

Sarcopenia is an age-related disease characterized by low muscle mass, strength and function, which associates with falls, fractur..