Danielle Debruin

The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle

Emma Rybalka, Cara A Timpani, Danielle A Debruin, Ryan M Bagaric, Dean G Campelj, Alan Hayes

Journal article  |  2020  |  Cells

Myostatin inhibition therapy has held much promise for the treatment of muscle wasting disorders. This is particularly true for th..

Sodium nitrate co-supplementation does not exacerbate low dose metronomic doxorubicin-induced cachexia in healthy mice

Dean G Campelj, Danielle A Debruin, Cara A Timpani, Alan Hayes, Craig A Goodman, Emma Rybalka

Journal article  |  2020  |  Scientific Reports

The purpose of this study was to determine whether (1) sodium nitrate (SN) treatment progressed or alleviated doxorubicin (DOX)-in..

Exercise May Ameliorate the Detrimental Side Effects of High Vitamin D Supplementation on Muscle Function in Mice

Danielle A Debruin, Cara A Timpani, Hannah Lalunio, Emma Rybalka, Craig A Goodman, Alan Hayes

Journal article  |  2020  |  Journal of Bone and Mineral Research

Vitamin D is commonly prescribed to normalize deficiencies and to treat osteoporosis. However, the effect vitamin D supplements ha..

The Effect of Yearly-Dose Vitamin D Supplementation on Muscle Function in Mice

Alan Hayes, Emma Rybalka, Danielle A Debruin, Erik D Hanson, David Scott, Kerrie Sanders

Journal article  |  2019  |  Nutrients

Supplementation with vitamin D helps to alleviate weakness and fatigue seen with deficiency. However, large bolus doses appear to ..