Lab focus: Ubiquitin ligase structure and function
In order to quickly react to challenges like damage to cellular components or infections, cells modify existing proteins by attaching small tags. Ubiquitin is one such tag and is attached by enzymes called E3 ubiquitin ligases.
E3 ubiquitin ligases act on very specific targets and regulate fundamental cellular processes.
However, they are also linked to diseases such as inflammation, cancer, and autoimmune or neurodegenerative diseases and may thus be new targets for innovative treatment options in these conditions.
We study E3 ubiquitin ligases to understand their functions in the human body and lay the groundwork for future drug discovery.
Find out more about Bernhard Lechtenberg's experience
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Bernhard Lechtenberg's selected work
Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis oute..
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signalin..
Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve H..
Displaying the 17 most recent scholarly works by Bernhard Lechtenberg.
Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail
Kyungsoo Shin, Bernhard C Lechtenberg, Lynn M Fujimoto, Yong Yao, Sara Schesser Bartra, Gregory V Plano, Francesca M Marassi
Journal article | 2019 | Science Advances
Vitronectin (Vn) is a major component of blood that controls many processes central to human biology. It is a drug target and a ke..
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling
Maricel Gomez-Soler, Marina Petersen Gehring, Bernhard C Lechtenberg, Elmer Zapata-Mercado, Kalina Hristova, Elena B Pasquale
Journal article | 2019 | Journal of Biological Chemistry
The EPH receptor A2 (EphA2) tyrosine kinase plays an important role in a plethora of biological and disease processes, ranging fro..
Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability
Erika J Olson, Bernhard C Lechtenberg, Chunxia Zhao, Elena Rubio de la Torre, Ilaria Lamberto, Stefan J Riedl, Philip E Dawson, Elena B Pasquale
Journal article | 2016 | ACS Medicinal Chemistry Letters
The Malignant Brain Tumor Repeats of Human SCML2 Bind to Peptides Containing Monomethylated Lysine
Clara M Santiveri, Bernhard C Lechtenberg, Mark D Allen, Aruna Sathyamurthy, Agnes M Jaulent, Stefan MV Freund, Mark Bycroft
Journal article | 2008 | Journal of Molecular Biology
SCML2 (sex comb on midleg-like 2) is a constituent of the Polycomb repressive complex 1, a large multiprotein assembly required fo..