Bernhard Lechtenberg

Design and characterization of a heterobifunctional degrader of KEAP1

Hao Chen, Nghi H Nguyen, Charlene M Magtoto, Simon A Cobbold, Grace M Bidgood, Lizeth G Meza Guzman, Lachlan W Richardson, Jason Corbin, Amanda E Au, Bernhard C Lechtenberg, Rebecca Feltham, Kate D Sutherland, Christoph Grohmann, Sandra E Nicholson, Brad E Sleebs

Journal article  |  2023  |  REDOX BIOLOGY

The Kelch-like ECH-associated protein 1 (KEAP1) - nuclear factor erythroid 2-related factor 2 (NRF2) signaling pathway senses reac..

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.

Xiangyi S Wang, Thomas R Cotton, Sarah J Trevelyan, Lachlan W Richardson, Wei Ting Lee, John Silke, Bernhard C Lechtenberg

Journal article  |  2023  |  Nat Commun

The RING-between-RING (RBR) E3 ubiquitin ligase family in humans comprises 14 members and is defined by a two-step catalytic mecha..

Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors

Dale J Calleja, Nathan Kuchel, Bernadine GC Lu, Richard W Birkinshaw, Theresa Klemm, Marcel Doerflinger, James P Cooney, Liana Mackiewicz, Amanda E Au, Yu Q Yap, Timothy R Blackmore, Kasiram Katneni, Elly Crighton, Janet Newman, Kate E Jarman, Melissa J Call, Bernhard C Lechtenberg, Peter E Czabotar, Marc Pellegrini, Susan A Charman, et al.

Journal article  |  2022  |  FRONTIERS IN CHEMISTRY

The COVID-19 pandemic continues unabated, emphasizing the need for additional antiviral treatment options to prevent hospitalizati..

Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signaling

Maricel Gomez-Soler, Marina P Gehring, Bernhard C Lechtenberg, Elmer Zapata-Mercado, Alyssa Ruelos, Mike W Matsumoto, Kalina Hristova, Elena B Pasquale

Journal article  |  2022  |  ISCIENCE

The EphA2 receptor tyrosine kinase activates signaling pathways with different, and sometimes opposite, effects in cancer and othe..

Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216

Thomas R Cotton, Simon A Cobbold, Jonathan P Bernardini, Lachlan W Richardson, Xiangyi S Wang, Bernhard C Lechtenberg

Journal article  |  2022  |  MOLECULAR CELL

An increasing number of genetic diseases are linked to deregulation of E3 ubiquitin ligases. Loss-of-function mutations in the RIN..

Regulation of the EphA2 receptor intracellular region by phosphomimetic negative charges in the kinase-SAM linker

Bernhard C Lechtenberg, Marina P Gehring, Taylor P Light, Christopher R Horne, Mike W Matsumoto, Kalina Hristova, Elena B Pasquale

Journal article  |  2021  |  NATURE COMMUNICATIONS

Eph receptor tyrosine kinases play a key role in cell-cell communication. Lack of structural information on the entire multi-domai..

A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain

Taylor P Light, Maricel Gomez-Soler, Zichen Wang, Kelly Karl, Elmer Zapata-Mercado, Marina P Gehring, Bernhard C Lechtenberg, Taras Pogorelov, Kalina Hristova, Elena B Pasquale

Journal article  |  2021  |  JOURNAL OF BIOLOGICAL CHEMISTRY

The Eph receptor tyrosine kinases and their ephrin ligands regulate many physiological and pathological processes. EphA4 plays imp..

Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2

Theresa Klemm, Gregor Ebert, Dale J Calleja, Cody C Allison, Lachlan W Richardson, Jonathan P Bernardini, Bernadine GC Lu, Nathan W Kuchel, Christoph Grohmann, Yuri Shibata, Zhong Yan Gan, James P Cooney, Marcel Doerflinger, Amanda E Au, Timothy R Blackmore, Gerbrand J van der Heden van Noort, Paul P Geurink, Huib Ovaa, Janet Newman, Alan Riboldi-Tunnicliffe, et al.

Journal article  |  2020  |  EMBO JOURNAL

The SARS-CoV-2 coronavirus encodes an essential papain-like protease domain as part of its non-structural protein (nsp)-3, namely ..

Chain reactions: molecular mechanisms of RBR ubiquitin ligases

Thomas R Cotton, Bernhard C Lechtenberg

Journal article  |  2020  |  BIOCHEMICAL SOCIETY TRANSACTIONS

Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ul..

Structure of human Vitronectin C-terminal domain and interaction with Yersinia pestis outer membrane protein Ail

Kyungsoo Shin, Bernhard C Lechtenberg, Lynn M Fujimoto, Yong Yao, Sara Schesser Bartra, Gregory V Plano, Francesca M Marassi

Journal article  |  2019  |  SCIENCE ADVANCES

Vitronectin (Vn) is a major component of blood that controls many processes central to human biology. It is a drug target and a ke..