Yifan Huang

Efflux transporters in rat placenta and developing brain: transcriptomic and functional response to paracetamol

LM Koehn, Y Huang, MD Habgood, S Nie, SY Chiou, RB Banati, KM Dziegielewska, NR Saunders

Journal article  |  2021  |  SCIENTIFIC REPORTS

Adenosine triphosphate binding cassette (ABC) transporters transfer lipid-soluble molecules across cellular interfaces either dire..

Entry of cystic fibrosis transmembrane conductance potentiator ivacaftor into the developing brain and lung.

Fiona Qiu, Mark D Habgood, Yifan Huang, Katarzyna M Dziegielewska, Sam Toll, Elena K Schneider-Futschik

Journal article  |  2021  |  J Cyst Fibros

BACKGROUND: The potential effects of ivacaftor during pregnancy and breastfeeding on the offspring are still unknown. This study a..

Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats

Liam M Koehn, Katarzyna M Dziegielewska, Mark D Habgood, Yifan Huang, Norman R Saunders

Journal article  |  2021  |  FLUIDS AND BARRIERS OF THE CNS

BACKGROUND: Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharm..

Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain.

Samuel J Toll, Fiona Qiu, Yifan Huang, Mark D Habgood, Katarzyna M Dziegielewska, Shuai Nie, Norman R Saunders

Journal article  |  2021  |  F1000Res

Background: Women with epilepsy face difficult choices whether to continue antiepileptic drug treatment during pregnancy, as uncon..

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain.

Liam M Koehn, Yifan Huang, Mark D Habgood, Kai Kysenius, Peter J Crouch, Katarzyna M Dziegielewska, Norman R Saunders

Journal article  |  2020  |  F1000Res

Background: Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as "safe" by regulatory authorities. Me..

Determinants of drug entry into the developing brain.

Liam Koehn, Mark Habgood, Yifan Huang, Katarzyna Dziegielewska, Norman Saunders

Journal article  |  2019  |  F1000Research

Background: A major concern for clinicians in prescribing medications to pregnant women and neonates is the possibility that drugs..

A bipedal mammalian model for spinal cord injury research: The tammar wallaby.

Norman R Saunders, Katarzyna M Dziegielewska, Sophie C Whish, Lyn A Hinds, Benjamin J Wheaton, Yifan Huang, Steve Henry, Mark D Habgood

Journal article  |  2017  |  F1000Res

Background: Most animal studies of spinal cord injury are conducted in quadrupeds, usually rodents. It is unclear to what extent f..