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Dr

Louise Rowntree

Research Officer
Microbiology And Immunology
MHC/HLA
Viruses
T cells
Influenza
Science
Humans
Adaptive immunity
Research
TCR
Louise Rowntree's Profile Picture
Dr

Louise Rowntree

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Immunology
Louise Rowntree's Profile Picture
Dr

Louise Rowntree

 
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Louise's  Short Profile
 

I recently joined the Kedzierska laboratory at The University of Melbourne to work on developing a universal influenza vaccine, with a particular focus on the vaccine components relevant to Australian Indigenous populations, and to asses its efficacy in preclinical and clinical settings. This involves molecular and functional characterisation of CD8+ T cells against influenza A and B viruses.

I was introduced to immunology research during my Honours year in the Central Clinical School at Monash University. I then undertook my PhD under the supervision of Dr Nicole Mifsud and A/Prof Tom Kotsimbos at Monash University with a focus on CD8+ T cell cross-reactivity. I was interested in whether T cells developed against particular viruses could reactivate in certain situations of solid organ transplantation. I completed my PhD in 2016 and continued my research into T cell cross-reactivity in the Purcell laboratory where I focused on identifying antigens presented by allogenic HLA which are cross-recognised by virus-specific T cells.

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Louise Rowntree's highlights

Scholarly Works

Displaying the 10 most recent scholarly works by Louise Rowntree.

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A dual antigen ELISA allows the assessment of SARS-CoV-2 antibody seroprevalence in a low transmission setting.

Sarah M Hicks, Kai Pohl, Teresa Neeman, Hayley A McNamara, Kate M Parsons, Jin-Shu He, Sidra A Ali, Samina Nazir, Louise C Rowntree, Thi HO Nguyen, Katherine Kedzierska, Denise L Doolan, Carola G Vinuesa, Matthew C Cook, Nicholas Coatsworth, Paul S Myles, Florian Kurth, Leif E Sander, Graham J Mann, Russell L Gruen, et al.

Journal article  |  2020  |  The Journal of Infectious Diseases

Estimates of seroprevalence of SARS-CoV-2 antibodies have been hampered by inadequate assay sensitivity and specificity. Using an ..

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Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

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A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02-Expressing Individuals

Louise C Rowntree, Thi HO Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A Mifsud

Journal article  |  2020  |  The Journal of Immunology

EBV is one of the most common viruses found in humans and is prototypic of a persistent viral infection characterized by periods o..

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PEPTIDE-DEPENDENT T CELL CROSS-REACTIVITY DRIVES ALLORECOGNITION.

Nicole A Mifsud, Louise C Rowntree, Patricia T Illing, Pouya Faridi, Sian Llewellyn-Lacey, Kelly L Miners, Kristin Ladell, James E McLaren, Carine Farencl, Augustine Hyland, Jan Petersen, Jamie Ross-John, Thi HO Nguyen, David A Price, Linda Wool-Dridge, Tom C Kotsimbos, Anthony W Purcell

Conference Proceedings  |  2020  |  HLA

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Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8( ) T Cell Receptors

Louise C Rowntree, Heleen van den Heuvel, Jessica Sun, Lloyd J D'Orsogna, Thi HO Nguyen, Frans HJ Claas, Jamie Rossjohn, Tom C Kotsimbos, Anthony W Purcell, Nicole A Mifsud

Journal article  |  2020  |  Frontiers in Immunology

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unw..

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Challenging immunodominance of influenza-specific CD8( ) T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

CE van de Sandt, EB Clemens, EJ Grant, LC Rowntree, S Sant, H Halim, J Crowe, AC Cheng, TC Kotsimbos, M Richards, A Miller, SYC Tong, J Rossjohn, THO Nguyen, S Gras, W Chen, K Kedzierska

Journal article  |  2019  |  Nature Communications

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease ar..

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Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses

Louise C Rowntree, Thi HO Nguyen, Hanim Halim, Anthony W Purcell, Jamie Rossjohn, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2018  |  The Journal of Immunology

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Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation

Louise C Rowntree, Thi HO Nguyen, Stephanie Gras, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2016  |  Current Opinion in Organ Transplantation

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Recognition of Distinct Cross-Reactive Virus-Specific CD8( ) T Cells Reveals a Unique TCR Signature in a Clinical Setting

Thi HO Nguyen, Louise C Rowntree, Daniel G Pellicci, Nicola L Bird, Andreas Handel, Lars Kjer-Nielsen, Katherine Kedzierska, Tom C Kotsimbos, Nicole A Mifsud

Journal article  |  2014  |  Journal of Immunology

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Human leucocyte antigen-defined microchimerism early post-transplant does not predict for stable lung allograft function

LC Rowntree, J Bayliss, THO Nguyen, TC Kotsimbos, NA Mifsud

Journal article  |  2013  |  Clinical & Experimental Immunology

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Scholarly Works

Keyword Analysis

Immunology
Clinical Health (organs, Diseases and Abnormal Conditions)
Expanding Knowledge

Credentials

Positions

Positions

Research Officer

Microbiology And Immunology

Australasian Society For Immunology

Australian and New Zealand Society for Immunology

Education

Education

PhD

Monash University

Links

Links