Jorg Heierhorst

Dynll1 is essential for development and promotes endochondral bone formation by regulating intraflagellar dynein function in primary cilia

Ashleigh King, Nicolas C Hoch, Narelle E McGregor, Natalie A Sims, Ian M Smyth, Jorg Heierhorst

Journal article  |  2019  |  Human Molecular Genetics

Mutations in subunits of the cilia-specific cytoplasmic Dynein-2 (CD2) complex cause short-rib thoracic dystrophy syndromes (SRTDs..

ATP-dependent helicase activity is dispensable for the physiological functions of Recql4

Wilson Castillo-Tandazo, Monique F Smeets, Vincent Murphy, Rui Liu, Charlotte Hodson, Joerg Heierhorst, Andrew J Deans, Carl R Walkley

Journal article  |  2019  |  PLoS Genetics

Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive disorder characterized by skin rash (poikiloderma), skeletal dysplas..

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

Jordan R Becker, Raquel Cuella-Martin, Marco Barazas, Rui Liu, Catarina Oliveira, Antony W Oliver, Kirstin Bilham, Abbey B Holt, Andrew N Blackford, Jorg Heierhorst, Jos Jonkers, Sven Rottenberg, J Ross Chapman

Journal article  |  2018  |  Nature Communications

Multivalency regulates activity in an intrinsically disordered transcription factor

Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jorg Heierhorst, Steve L Reichow, Elisar J Barbar

Journal article  |  2018  |  eLife

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

Rui Liu, Ashleigh King, Philippe Bouillet, David M Tarlinton, Andreas Strasser, Jorg Heierhorst

Journal article  |  2018  |  Frontiers in Immunology

Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms

Ashleigh King, Lingli Li, David M Wong, Rui Liu, Rebecca Bamford, Andreas Strasser, David M Tarlinton, Jorg Heierhorst

Journal article  |  2017  |  PLoS Genetics

ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress

Rui Liu, Ashleigh King, Nicolas C Hoch, Catherine Chang, Gemma L Kelly, Andrew J Deans, Jorg Heierhorst

Journal article  |  2017  |  DNA Repair

Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway

Sylvie van Twest, Vincent J Murphy, Charlotte Hodson, Winnie Tan, Paolo Swuec, Julienne J O'Rourke, Jorg Heierhorst, Wayne Crismani, Andrew J Deans

Journal article  |  2017  |  Molecular Cell

Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays

NC Hoch, ES-W Chen, M-D Tsai, J Heierhorst

Book Chapter  |  2017  |  Methods in Enzymology

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma

David M Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K Walia, Gemma L Kelly, Carl R Walkley, David M Tarlinton, Andreas Strasser, Joerg Heierhorst

Journal article  |  2016  |  Cell Reports