Jeffrey Babon

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  Journal of Experimental Medicine

Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammation

Mary Speir, Cameron J Nowell, Alyce A Chen, Joanne A O'Donnell, Isaac S Shamie, Paul R Lakin, Akshay A D'Cruz, Roman O Braun, Jeff J Babon, Rowena S Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H Cengia, Anca I Stoica, Razq Hakem, Michelle A Kelliher, Lorraine A O'Reilly, Heather Patsiouras, Kate E Lawlor, et al.

Journal article  |  2020  |  Nature Immunology

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-ind..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  Cancers

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6R alpha)

Jeffrey J Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose Villadangos, Alan Ching, Satoshi Ishido, Douglas J Hilton, Warren S Alexander, Nicos A Nicola

Journal article  |  2019  |  Biochemical Journal

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article  |  2019  |  Journal of Magnetic Resonance

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Simon H Jiang, Vicki Athanasopoulos, Julia Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A Roco, Ilenia Papa, Mehmet Yabas, Giles D Walters, Gaetan Burgio, Kathryn McKeon, James M Byers, Charlotte Burrin, Anselm Enders, Lisa A Miosge, et al.

Journal article  |  2019  |  Nature Communications

Measuring translational diffusion of N-15-enriched biomolecules in complex solutions with a simplified H-1-N-15 HMQC-filtered BEST sequence

Shenggen Yao, Thomas G Meikle, Ashish Sethi, Frances Separovic, Jeffrey J Babon, David W Keizer

Journal article  |  2018  |  European Biophysics Journal

The molecular details of cytokine signaling via the JAK/STAT pathway

Rhiannon Morris, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2018  |  Protein Science

Accumulation of JAK Activation-Loop Phosphorylation Promotes Type I JAK Inhibitor Withdrawal Syndrome in Myelofibrosis

Denis Tvorogov, Daniel Thomas, Nicholas PD Liau, Mara Dottore, Emma F Barry, Maya Lathi, Winnie L Kan, Tim R Hercus, Frank Stomski, Timothy P Hughes, Vinay Tergaonkar, Michael W Parker, David M Ross, Jeffrey J Babon, Ravindra Majeti, Angel F Lopez

Conference Proceedings  |  2018  |  Blood