Jeffrey Babon

Dissecting the molecular control of Interleukin 6 signaling using the M1 cell line

Rhiannon Morris, Douglas J Hilton, Andrew Jarratt, Jeffrey J Babon

Journal article  |  2021  |  CYTOKINE

Interleukin 6 is the classical member of the IL-6 family of cytokines which triggers activation of the JAK/STAT signaling cascade ..

Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2021  |  JOURNAL OF PHYSICAL CHEMISTRY B

Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is..

Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR

Thomas G Meikle, David W Keizer, Jeffrey J Babon, Calum J Drummond, Frances Separovic, Charlotte E Conn, Shenggen Yao

Journal article  |  2020  |  LANGMUIR

Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Cynthia Louis, Fernando Souza-Fonseca-Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at si..

NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (vol 217, e20191421, 2020)

Cynthia Louis, Fernando Guimaraes, Yuyan Yang, Damian D'Silva, Tobias Kratina, Laura Dagley, Soroor Hediyeh-Zadeh, Jai Rautela, Seth Lucian Masters, Melissa J Davis, Jeffrey J Babon, Bogoljub Ciric, Eric Vivier, Warren S Alexander, Nicholas D Huntington, Ian P Wicks

Journal article  |  2020  |  JOURNAL OF EXPERIMENTAL MEDICINE

JEM regrets that in the original version of this paper, Fernando Souza-Fonseca-Guimaraes's name was mistakenly written as "Fernand..

Ptpn6 inhibits caspase-8-and Ripk3/Mlkl-dependent inflammation

Mary Speir, Cameron J Nowell, Alyce A Chen, Joanne A O'Donnell, Isaac S Shamie, Paul R Lakin, Akshay A D'Cruz, Roman O Braun, Jeff J Babon, Rowena S Lewis, Meghan Bliss-Moreau, Inbar Shlomovitz, Shu Wang, Louise H Cengia, Anca I Stoica, Razq Hakem, Michelle A Kelliher, Lorraine A O'Reilly, Heather Patsiouras, Kate E Lawlor, et al.

Journal article  |  2020  |  NATURE IMMUNOLOGY

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-ind..

Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1

Nicholas PD Liau, Artem Laktyushin, Rhiannon Morris, Jarrod J Sandow, Nicos A Nicola, Nadia J Kershaw, Jeffrey J Babon

Journal article  |  2019  |  CANCERS

Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cyt..

Membrane-associated RING-CH (MARCH) proteins down-regulate cell surface expression of the interleukin-6 receptor alpha chain (IL6R alpha)

Jeffrey J Babon, Dina Stockwell, Ladina DiRago, Jian-Guo Zhang, Artem Laktyushin, Jose Villadangos, Alan Ching, Satoshi Ishido, Douglas J Hilton, Warren S Alexander, Nicos A Nicola

Journal article  |  2019  |  BIOCHEMICAL JOURNAL

Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL..

Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids

Thomas G Meikle, Ashish Sethi, David W Keizer, Jeffrey J Babon, Frances Separovic, Paul R Gooley, Charlotte E Conn, Shenggen Yao

Journal article  |  2019  |  JOURNAL OF MAGNETIC RESONANCE

Lipidic cubic phases, which form spontaneously via the self-assembly of certain lipids in an aqueous environment, are highly prosp..

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Simon H Jiang, Vicki Athanasopoulos, Julia Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A Roco, Ilenia Papa, Mehmet Yabas, Giles D Walters, Gaetan Burgio, Kathryn McKeon, James M Byers, Charlotte Burrin, Anselm Enders, Lisa A Miosge, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease. It is thought that many common variant gene loci..