Iresha Ambepitiya Wickramasinghe

Eight-Color Multiplex Immunohistochemistry for Simultaneous Detection of Multiple Immune Checkpoint Molecules within the Tumor Microenvironment.

Mark AJ Gorris, Altuna Halilovic, Katrin Rabold, Anne van Duffelen, Iresha N Wickramasinghe, Dagmar Verweij, Inge MN Wortel, Johannes C Textor, I Jolanda M de Vries, Carl G Figdor

Journal article  |  2018  |  The Journal of Immunology

Therapies targeting immune checkpoint molecules CTLA-4 and PD-1/PD-L1 have advanced the field of cancer immunotherapy. New mAbs ta..

A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors.

Robert P de Vries, Netanel Tzarum, Wenjie Peng, Andrew J Thompson, Iresha N Ambepitiya Wickramasinghe, Alba T Torrents de la Pena, Marielle J van Breemen, Kim M Bouwman, Xueyong Zhu, Ryan McBride, Wenli Yu, Rogier W Sanders, Monique H Verheije, Ian A Wilson, James C Paulson

Journal article  |  2017  |  EMBO Molecular Medicine

In June 2013, the first case of human infection with an avian H6N1 virus was reported in a Taiwanese woman. Although this was a si..

Three mutations switch H7N9 influenza to human-type receptor specificity.

Robert P de Vries, Wenjie Peng, Oliver C Grant, Andrew J Thompson, Xueyong Zhu, Kim M Bouwman, Alba T Torrents de la Pena, Marielle J van Breemen, Iresha N Ambepitiya Wickramasinghe, Cornelis AM de Haan, Wenli Yu, Ryan McBride, Rogier W Sanders, Robert J Woods, Monique H Verheije, Ian A Wilson, James C Paulson

Journal article  |  2017  |  PLoS Pathogens

The avian H7N9 influenza outbreak in 2013 resulted from an unprecedented incidence of influenza transmission to humans from infect..

Novel Receptor Specificity of Avian Gammacoronaviruses That Cause Enteritis

IN Ambepitiya Wickramasinghe, RP de Vries, EAWS Weerts, SJ van Beurden, W Peng, R McBride, M Ducatez, J Guy, P Brown, N Eterradossi, A Groene, JC Paulson, MH Verheijea

Journal article  |  2015  |  Journal of Virology

ABSTRACTViruses exploit molecules on the target membrane as receptors for attachment and entry into host cells. Thus, receptor exp..

Protein histochemistry using coronaviral spike proteins: studying binding profiles and sialic acid requirements for attachment to tissues.

Iresha N Ambepitiya Wickramasinghe, M Hélène Verheije

Book Chapter  |  2015  |  Methods in Molecular Biology

Protein histochemistry is a tissue-based technique that enables the analysis of viral attachment patterns as well as the identific..

Host tissue and glycan binding specificities of avian viral attachment proteins using novel avian tissue microarrays.

Iresha N Ambepitiya Wickramasinghe, Robert P de Vries, Amber M Eggert, Nantaporn Wandee, Cornelis AM de Haan, Andrea Gröne, Monique H Verheije

Journal article  |  2015  |  PLoS One

The initial interaction between viral attachment proteins and the host cell is a critical determinant for the susceptibility of a ..

The avian coronavirus spike protein

IN Ambepitiya Wickramasinghe, SJ van Beurden, EAWS Weerts, MH Verheije

Journal article  |  2014  |  Virus Research

Contributions of the S2 spike ectodomain to attachment and host range of infectious bronchitis virus

N Promkuntod, IN Ambepitiya Wickramasinghe, G de Vrieze, A Grone, MH Verheije

Journal article  |  2013  |  Virus Research

Adaptation of novel H7N9 influenza A virus to human receptors

JCFM Dortmans, J Dekkers, IN Ambepitiya Wickramasinghe, MH Verheije, PJM Rottier, FJM van Kuppeveld, E de Vries, CAM de Haan

Journal article  |  2013  |  Scientific Reports

Binding of Avian Coronavirus Spike Proteins to Host Factors Reflects Virus Tropism and Pathogenicity

IN Ambepitiya Wickramasinghe, RP de Vries, A Grone, CAM de Haan, MH Verheije

Journal article  |  2011  |  Journal of Virology