Robert Rome

Endometriosis and menopausal hormone therapy impact the hysterectomy-ovarian cancer association.

Lilah Khoja, Rachel Palmieri Weber, undefined Australian Ovarian Cancer Study Group, Penelope M Webb, Susan J Jordan, Aruna Muthukumar, Jenny Chang-Claude, Renée T Fortner, Allan Jensen, Susanne K Kjaer, Harvey Risch, Jennifer Anne Doherty, Holly R Harris, Marc T Goodman, Francesmary Modugno, Kirsten Moysich, Andrew Berchuck, Joellen M Schildkraut, Daniel Cramer, Kathryn L Terry, et al.

Journal article  |  2022  |  Gynecol Oncol

OBJECTIVE: To evaluate the association between hysterectomy and ovarian cancer, and to understand how hormone therapy (HT) use and..

Prognostic gene expression signature for high-grade serous ovarian cancer

J Millstein, T Budden, EL Goode, MS Anglesio, A Talhouk, MP Intermaggio, HS Leong, S Chen, W Elatre, B Gilks, T Nazeran, M Volchek, RC Bentley, C Wang, DS Chiu, S Kommoss, SCY Leung, J Senz, A Lum, V Chow, et al.

Journal article  |  2020  |  ANNALS OF ONCOLOGY

BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies ..

Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature.

Carolin Poon, Robert Rome

Journal article  |  2020  |  Aust N Z J Obstet Gynaecol

BACKGROUND: The malignant transformation of endometriosis within the ovary is a recognised condition. There is less literature sur..

Developing an Australian multi-module clinical quality registry for gynaecological cancers: a protocol paper.

Natalie Heriot, Alison Brand, Paul Cohen, Sue Hegarty, Simon Hyde, Yee Leung, John R Zalcberg, Robert Rome

Journal article  |  2020  |  BMJ Open

INTRODUCTION: Gynaecological cancers collectively account for almost 10% of cancer diagnoses made in Australian women. The extent ..

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria Harrell, Giada Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B Pearson, John J Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J Hutt, Scott H Kaufmann, et al.

Journal article  |  2018  |  NATURE COMMUNICATIONS

Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibi..

Long-Term Survival After Surgery and Radiotherapy for Recurrent or Persistent Ovarian and Tubal Cancer.

Robert Rome, Joanna Dipnall, Sam Leung

Journal article  |  2018  |  Int J Gynecol Cancer

OBJECTIVE: This study examines the factors associated with long-term disease-specific survival (DSS) and complications after radio..

BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition

Tania Moujaber, Dariush Etemadmoghadam, Catherine J Kennedy, Yoke-Eng Chiew, Rosemary L Balleine, Catherine Saunders, Gerard Wain, Bo Gao, Russell Hogg, Sivatharsny Srirangan, Casina Kan, Sian Fereday, Nadia Traficante, Ann-Marie Patch, John Pearson, Nicola Waddell, Sean M Grimmond, Alexander Dobrovic, David DL Bowtell, Paul R Harnett, et al.

Journal article  |  2018  |  JCO PRECISION ONCOLOGY

PURPOSE: Low-grade serous ovarian carcinoma (LGSC) responds poorly to chemotherapy and is characterized by activating mutations in..

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  CLINICAL CANCER RESEARCH

Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..

Prognostic significance of steroid receptor positivity and adjuvant progestogen use in endometrial stromal sarcoma

Thomas J Cade, Michael A Quinn, Robert M Rome, Alexander Polyakov

Journal article  |  2014  |  AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

BACKGROUND: The prognostic significance of oestrogen and progesterone receptors (ER/PR) in endometrial stromal sarcoma (ESS) has c..

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao, Amanda Russell, Jonathan Beesley, Xiao Qing Chen, Sue Healey, Michelle Henderson, Mark Wong, Catherine Emmanuel, Laura Galletta, Sharon E Johnatty, David Bowtell, Michelle Haber, Murray Norris, Paul Harnett, Georgia Chenevix-Trench, Rosemary L Balleine, Anna deFazio

Journal article  |  2014  |  SCIENTIFIC REPORTS

ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents inclu..