Lakmie Gunarathne

Cirrhotic portal hypertension: From pathophysiology to novel therapeutics

Lakmie S Gunarathne, Harinda Rajapaksha, Nicholas Shackel, Peter W Angus, Chandana B Herath

Journal article  |  2020  |  World Journal of Gastroenterology

Portal hypertension and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in patients with cirr..

Liver-Targeted Angiotensin Converting Enzyme 2 Therapy Inhibits Chronic Biliary Fibrosis in Multiple Drug-Resistant Gene 2-Knockout Mice

Indu G Rajapaksha, Lakmie S Gunarathne, Khashayar Asadi, Sharon C Cunningham, Alexandra Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  Hepatology Communications

Blockade of Mas Receptor or Mas-Related G-Protein Coupled Receptor Type D Reduces Portal Pressure in Cirrhotic but Not in Non-cirrhotic Portal Hypertensive Rats

Lakmie S Gunarathne, Peter W Angus, Chandana B Herath

Journal article  |  2019  |  Frontiers in Physiology

Therapeutic potential of targeting the protective arm of the renin angiotensin system in cirrhotic and non-cirrhotic portal hypertension

Withanage Don Lakmie Suranjika Gunarathne

Thesis / Dissertation  |  2019

Portal hypertension (PHT) and bleeding from gastroesophageal varices is the major cause of morbidity and mortality in cirrhotic pa..

Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options

Indu G Rajapaksha, Lakmie S Gunarathne, Peter W Angus, Chandana B Herath

Journal article  |  Journal of Clinical Medicine

There is considerable experimental evidence that the renin angiotensin system (RAS) plays a central role in both hepatic fibrogene..