Tom Edwards

Neuronal Reprogramming for Tissue Repair and Neuroregeneration

Roxanne Hsiang-Chi Liou, Thomas L Edwards, Keith R Martin, Raymond Ching-Bong Wong

Journal article  |  2020  |  International Journal of Molecular Sciences

Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural r..

The genetic and clinical landscape of nanophthalmos and posterior microphthalmos in an Australian cohort

Owen M Siggs, Mona S Awadalla, Emmanuelle Souzeau, Sandra E Staffieri, Lisa S Kearns, Kate Laurie, Abraham Kuot, Ayub Qassim, Thomas L Edwards, Michael A Coote, Erica Mancel, Mark J Walland, Joanne Dondey, Anna Galanopoulous, Robert J Casson, Richard A Mills, Daniel G MacArthur, Jonathan B Ruddle, Kathryn P Burdon, Jamie E Craig

Journal article  |  2020  |  Clinical Genetics

Nanophthalmos and posterior microphthalmos are ocular abnormalities in which both eyes are abnormally small, and typically associa..

Highest reported visual acuity after electronic retinal implantation.

Jasmina Cehajic Kapetanovic, Nicole Troelenberg, Thomas L Edwards, Kanmin Xue, James D Ramsden, Alfred Stett, Eberhart Zrenner, Robert E MacLaren

Journal article  |  2020  |  Acta Ophthalmologica

PURPOSE: To report the highest attained visual acuity with an electronic retinal implant for the treatment of advanced retinal deg..

Refractive Outcomes of the Yamane Flanged Intrascleral Haptic Fixation Technique.

John R Rocke, Myra B McGuinness, William K Atkins, Lewis E Fry, Jack X Kane, David CA Fabinyi, Jonathan Yeoh, Daniel Chiu, Rohan W Essex MBiostat, Edward Roufail, Amy M Sheridan, Penelope J Allen, Thomas L Edwards

Conference Proceedings  |  2020  |  Ophthalmology

Outcomes of one hundred and fifteen consecutive scleral fixated intraocular lenses using the 'yamane' flanged intrascleral haptic fixation technique

John Rocke, William Atkins, Myra McGuinness, Lewis Fry, Jack Kane, David Fabinyi, Jonathan Yeoh, Daniel Chiu, Rohan Essex, Edward Roufail, Amy Sheridan, Thomas Edwards

Conference Proceedings  |  2019  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Yamane sutureless scleral fixated intraocular lenses: the Victorian experience

John R Rocke, Lewis Fry, Will Atkins, David Fabinyi, Amy Sheridan, Penelope J Allen, Thomas Edwards

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

First in human clinical trial of robot-assisted subretinal drug delivery under local anaesthesia

Jasmina Cehajic Kapetanovic, Kanmin Xue, Thomas Edwards, Thijs CM Meenink, Maarten J Beelen, Gerrit JL Naus, Marc D de Smet, Robert E MacLaren

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Is post-operative perfluorocarbon liquid tamponade for macula-on giant retinal tear safer than silicone oil?

Amy M Sheridan, Rohan W Essex, Jonathan Yeoh, Penelope Allen, William G Campbell, Thomas L Edwards

Journal article  |  2019  |  Eye

Gene therapy for visual loss: Opportunities and concerns

Jia Hui Lee, Jiang-Hui Wang, Jinying Chen, Fan Li, Thomas L Edwards, Alex W Hewitt, Guei-Sheung Liu

Journal article  |  2019  |  Progress in Retinal and Eye Research

Beneficial effects on vision in patients undergoing retinal gene therapy for choroideremia

Kanmin Xue, Jasleen K Jolly, Alun R Barnard, Anna Rudenko, Anna P Salvetti, Maria I Patricio, Thomas L Edwards, Markus Groppe, Harry O Orlans, Tanya Tolmachova, Graeme C Black, Andrew R Webster, Andrew J Lotery, Graham E Holder, Susan M Downes, Miguel C Seabra, Robert E MacLaren

Journal article  |  2018  |  Nature Medicine

First-in-human study of the safety and viability of intraocular robotic surgery

TL Edwards, K Xue, HCM Meenink, MJ Beelen, GJL Naus, MP Simunovic, M Latasiewic, AD Farmery, MD de Smet, RE MacLaren

Journal article  |  2018  |  Nature Biomedical Engineering

A first-in-man trial assessing robotic surgery inside the human eye to perform a subretinal injection

Thomas L Edwards, Kanmin Xue, Thijs Meenink, Maarten Beelen, Gerrit Naus, Matthew P Simunovic, Marta Latasiewicz, Andrew Farmery, Marc D De Smet, Robert E MacLaren

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa

Thomas L Edwards, Charles L Cottriall, Kanmin Xue, Matthew P Simunovic, James D Ramsden, Eberhart Zrenner, Robert E MacLaren

Journal article  |  2018  |  Ophthalmology

Robot-assisted vitreoretinal surgery: current perspectives.

Marina Roizenblatt, Thomas L Edwards, Peter L Gehlbach

Journal article  |  2018  |  Robotic Surgery: Research and Reviews

Vitreoretinal microsurgery is among the most technically challenging of the minimally invasive surgical techniques. Exceptional pr..

Novel non-contiguous exon duplication in choroideremia

TL Edwards, J Williams, MI Patricio, MP Simunovic, M Shanks, P Clouston, RE MacLaren

Journal article  |  2018  |  Clinical Genetics

Human Retinal Explant Culture for Ex Vivo Validation of AAV Gene Therapy

Harry O Orlans, Thomas L Edwards, Samantha R De Silva, Maria I Patricio, Robert E MacLaren

Book Chapter  |  2018  |  Methods in Molecular Biology

Discovery of Maori and Polynesian phototransduction pathway founder mutation: what is the gene and what does it mean?

Thomas L Edwards

Journal article  |  2017  |  Clinical & Experimental Ophthalmology

Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

DG Hickey, TL Edwards, AR Barnard, MS Singh, SR de Silva, ME McClements, JG Flannery, MW Hankins, RE MacLaren

Journal article  |  2017  |  Gene Therapy

Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS

Laura Kuehlewein, Veronique Kitiratschky, Mariya Gosheva, Thomas L Edwards, Robert E MacLaren, Markus Groppe, Akos Kusnyerik, Cristina Soare, Timothy L Jackson, Chen-Hsin Sun, Caroline Chee, Helmut Sachs, Krunoslav Stingl, Barbara Wilhelm, Florian Gekeler, Ulrich Bartz-Schmidt, Eberhart Zrenner, Katarina Stingl

Conference Proceedings  |  2017  |  Ophthalmic Surgery, Lasers and Imaging Retina

Characterizing the Natural History of Visual Function in Choroideremia Using Microperimetry and Multimodal Retinal Imaging

Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Robert E MacLaren

Journal article  |  2017  |  Investigative Opthalmology & Visual Science

Interim Results of a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherited Retinal Degenerations

Katarina Stingl, Ruth Schippert, Karl U Bartz-Schmidt, Dorothea Besch, Charles L Cottriall, Thomas L Edwards, Florian Gekeler, Udo Greppmaier, Katja Kiel, Assen Koitschev, Laura Kuehlewein, Robert E MacLaren, James D Ramsden, Johann Roider, Albrecht Rothermel, Helmut Sachs, Greta S Schroeder, Jan Tode, Nicole Troelenberg, Eberhart Zrenner

Journal article  |  2017  |  Frontiers in Neuroscience

Characterizing the natural history of visual function in choroideremia using microperimetry and multimodal retinal imaging

Kanmin Xue, Jasleen K Jolly, Thomas Edwards, Markus Groppe, Robert E MacLaren

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Results from a Multicenter Trial with the New Electronic Subretinal Implant Alpha AMS in 15 Patients Blind from Inherired Retinal Dystrophies (RD)

Eberhart Zrenner, Karl-Ulrich Bartz-Schmidt, Charles L Cottriall, Thomas Edwards, Florian Gekeler, Udo Greppmaier, Laura Kuehlewein, Robert E MacLaren, James Ramsden, Johann Roider, Helmut G Sachs, Ruth Schippert, Jan Tode, Nicole Troelenberg, Katarina Stingl

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Sub-retinal implantation of the Retinal Implant Alpha AMS chip using integrated intra-operative optical coherence tomography

Thomas Edwards, Charles L Cottriall, James D Ramsden, Matthew Simunovic, Kanmin Xue, Eberhart Zrenner, Robert E MacLaren

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Optical coherence tomography in patients with Alpha IMS subretinal implant

Laura Kuehlewein, Veronique Kitiratschky, Mariya Gosheva, Thomas Edwards, Robert E MacLaren, Akos Kusnyerik, Cristina Angelescu, Timothy L Jackson, Chen-Hsin Sun, Caroline Chee, Helmut G Sachs, Barbara Wilhelm, Florian Gekeler, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, Katarina Stingl

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

EX VIVO AAV-MEDIATED GENE EXPRESSION IN THE HUMAN RETINA

HO Orlans, TL Edwards, M Patricio, RE MacLaren

Conference Proceedings  |  2017  |  EUROPEAN JOURNAL OF OPHTHALMOLOGY

INVESTIGATION OF THE RELATIONSHIP BETWEEN LEVELS OF CHM GENE EXPRESSION AND RATE OF DISEASE PROGRESSION IN CHOROIDEREMIA

M Patricio, K Xue, LC Chandler, AR Barnard, JK Jolly, TL Edwards, ME McClements, RE MacLaren

Conference Proceedings  |  2017  |  EUROPEAN JOURNAL OF OPHTHALMOLOGY

The Spectrum of CHM Gene Mutations in Choroideremia and Their Relationship to Clinical Phenotype

Matthew P Simunovic, Jasleen K Jolly, Kanmin Xue, Thomas L Edwards, Markus Groppe, Susan M Downes, Robert E MacLaren

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

SUSTAINED IMPROVEMENT IN VISUAL ACUITY AFTER RETINAL GENE THERAPY FOR CHOROIDEREMIA

Thomas Edwards, Jasleen Jolly, Markus Groppe, Alun Barnard, Charles Cottriall, Tanya Tolmachova, Graeme Black, Andrew Lotery, Graham Holder, Kanmin Xue, Susan Downes, Matthew Simunovic, Miguel Seabra, Robert MacLaren

Conference Proceedings  |  2016  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Preliminary Findings from the Oxford Retinal Implant Alpha AMS Trial

Thomas L Edwards, Charles L Cottriall, Matthew P Simunovic, James D Ramsden, Eberhart Zrenner, Robert E MacLaren

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Long term vision results following retinal gene therapy for choroideremia

Robert E MacLaren, Thomas L Edwards, Jasleen Jolly, Alun R Barnard, Kanmin Xue, Susan Downes, Graham E Holder, Graeme CM Black, Andrew J Lotery, Andrew Webster, Miguel Seabra

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A Qualitative and Quantitative Assessment of Fundus Autofluorescence Patterns in Patients With Choroideremia

Jasleen K Jolly, Thomas L Edwards, Jonathan Moules, Markus Groppe, Susan M Downes, Robert E MacLaren

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia

Kanmin Xue, Marta Oldani, Jasleen K Jolly, Thomas L Edwards, Markus Groppe, Susan M Downes, Robert E MacLaren

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

Visual Acuity after Retinal Gene Therapy for Choroideremia

Thomas L Edwards, Jasleen K Jolly, Markus Groppe, Alun R Barnard, Charles L Cottriall, Tanya Tolmachova, Graeme C Black, Andrew R Webster, Andrew J Lotery, Graham E Holder, Kanmin Xue, Susan M Downes, Matthew P Simunovic, Miguel C Seabra, Robert E MacLaren

Journal article  |  2016  |  New England Journal of Medicine

Correlation of Retinal Structure and Function in Choroideremia Carriers

Thomas L Edwards, Markus Groppe, Jasleen K Jolly, Susan M Downes, Robert E MacLaren

Journal article  |  2015  |  Ophthalmology

Outcomes following cataract surgery in choroideremia

TL Edwards, M Groppe, RE MacLaren

Journal article  |  2015  |  Eye

The Test-Retest Reliability of the Photopic Negative Response (PhNR)

Jessica Tang, Thomas Edwards, Jonathan G Crowston, Marc Sarossy

Journal article  |  2014  |  Translational Vision Science & Technology

Sympathetic ophthalmia after diode laser cyclophotocoagulation: now an issue in informed consent

Thomas L Edwards, Penny McKelvie, Mark J Walland

Journal article  |  2014  |  Canadian Journal of Ophthalmology

Familial retinal detachment associated with COL2A1 exon 2 and FZD4 mutations

Thomas L Edwards, Benjamin O Burt, Graeme CM Black, Rahat Perveen, Lisa S Kearns, Sandra E Staffieri, Carmel Toomes, Robert G Buttery, David A Mackey

Journal article  |  2012  |  Clinical and Experimental Ophthalmology

Familial retinal detachment associated with COL2A1 exon 2 and FZD4 mutations

TL Edwards, BO Burt, GCM Black, R Perveen, LS Kearns, SE Staffieri, C Toomes, RG Buttery, DA Mackey

Journal article  |  2012  |  Clinical and Experimental Ophthalmology

Telemedicine model to prevent blindness from familial glaucoma

Sandra E Staffieri, Jonathan B Ruddle, Lisa S Kearns, Julie M Barbour, Thomas L Edwards, Padma Paul, David A Mackey

Journal article  |  2011  |  Clinical and Experimental Ophthalmology

Erratum: Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. (Biochemical Journal (2009) vol. 423 (31-39))

TL Edwards, VE Clowes, HTH Tsang, JW Connell, CM Sanderson, JP Luzio, E Reid

Journal article  |  2009  |  Biochemical Journal

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5 (vol 423, pg 31, 2009)

TL Edwards, VE Clowes, HTH Tsang, JW Connell, CM Sanderson, JP Luzio, E Reid

Journal article  |  2009  |  BIOCHEMICAL JOURNAL

The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling

Hilda TH Tsang, Thomas L Edwards, Xinnan Wang, James W Connell, Rachel J Davies, Hannah J Durrington, Cahir J O'Kane, J Paul Luzio, Evan Reid

Journal article  |  2009  |  Human Molecular Genetics

Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5

Thomas L Edwards, Virginia E Clowes, Hilda TH Tsang, James W Connell, Christopher M Sanderson, J Paul Luzio, Evan Reid

Journal article  |  2009  |  Biochemical Journal

Is second eye involvement in Leber's hereditary optic neuropathy due to retro-chiasmal spread of apoptosis?

Thomas L Edwards, Robert G Buttery, David A Mackey

Journal article  |  2007  |  Neuro-Ophthalmology

Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners

CM Sanderson, JW Connell, NA Bright, S Duley, A Thompson, JP Luzio, E Reid

Journal article  |  2006  |  Human Molecular Genetics

The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B

E Reid, J Connell, S Duley, SE Brown, CM Sanderson

Journal article  |  2005  |  Human Molecular Genetics

Prevalence and aetiology of lymphoedema after breast cancer treatment in southern Tasmania

TL Edwards

Journal article  |  2000  |  ANZ Journal of Surgery