Tom Edwards

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells.

Tu Nguyen, Daniel Urrutia-Cabrera, Luozixian Wang, Jarmon G Lees, Jiang-Hui Wang, Sandy SC Hung, Alex W Hewitt, Thomas L Edwards, Sam McLenachan, Fred K Chen, Shiang Y Lim, Chi D Luu, Robyn Guymer, Raymond CB Wong

Journal article  |  2023  |  Aging (Albany NY)

Genetic and epidemiologic studies have significantly advanced our understanding of the genetic factors contributing to age-related..

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes.

Jiang-Hui Wang, Daniel Urrutia-Cabrera, Jarmon G Lees, Santiago Mesa Mora, Tu Nguyen, Sandy SC Hung, Alex W Hewitt, Shiang Y Lim, Thomas L Edwards, Raymond CB Wong

Journal article  |  2023  |  Int J Mol Sci

Age-related macular degeneration (AMD) is a blinding disease characterised by dysfunction of the retinal pigmented epithelium (RPE..

The Diagnostic Yield of Next Generation Sequencing in Inherited Retinal Diseases: A Systematic Review and Meta-analysis.

Alexis Ceecee Britten-Jones, Sena A Gocuk, Kai Lyn Goh, Aamira Huq, Thomas L Edwards, Lauren N Ayton

Journal article  |  2022  |  Am J Ophthalmol

PURPOSE: Accurate genotyping of individuals with inherited retinal diseases (IRD) is essential for patient management and identify..

Survey of perspectives of people with inherited retinal diseases on ocular gene therapy in Australia

Heather G Mack, Alexis Ceecee Britten-Jones, Myra B McGuinness, Fred K Chen, John R Grigg, Robyn V Jamieson, Thomas L Edwards, John De Roach, Fleur O'Hare, Keith R Martin, Lauren N Ayton

Journal article  |  2022  |  GENE THERAPY

Many gene therapies are in development for treating people with inherited retinal diseases (IRD). We hypothesized that potential r..

Victorian evolution of inherited retinal diseases natural history registry (VENTURE study): Rationale, methodology and initial participant characteristics

Alexis Ceecee Britten-Jones, Fleur O'Hare, Thomas L Edwards, Lauren N Ayton

Journal article  |  2022  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

BACKGROUND: Emerging treatments are being developed for inherited retinal diseases, requiring a clear understanding of natural pro..

AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models

Jiang-Hui Wang, Grace E Lidgerwood, Maciej Daniszewski, Monica L Hu, Georgina E Roberts, Raymond CB Wong, Sandy SC Hung, Michelle E McClements, Alex W Hewitt, Alice Pebay, Doron G Hickey, Thomas L Edwards

Journal article  |  2022  |  SCIENTIFIC REPORTS

Bietti crystalline dystrophy (BCD) is an inherited retinal disease (IRD) caused by mutations in the CYP4V2 gene. It is a relativel..

First-in-Human Robot-Assisted Subretinal Drug Delivery Under Local Anesthesia.

Jasmina Cehajic-Kapetanovic, Kanmin Xue, Thomas L Edwards, Thijs C Meenink, Maarten J Beelen, Gerrit J Naus, Marc D de Smet, Robert E MacLaren

Journal article  |  2022  |  Am J Ophthalmol

PURPOSE: To report the results of a first-in-human study using a robotic device to assist subretinal drug delivery in patients und..

The safety and efficacy of gene therapy treatment for monogenic retinal and optic nerve diseases: A systematic review

Alexis Ceecee Britten-Jones, Rui Jin, Sena A Gocuk, Elise Cichello, Fleur O'Hare, Doron G Hickey, Thomas L Edwards, Lauren N Ayton

Journal article  |  2022  |  GENETICS IN MEDICINE

PURPOSE: This study aimed to systematically review and summarize gene therapy treatment for monogenic retinal and optic nerve dise..

Intereye Symmetry in Bietti Crystalline Dystrophy

Zhengyang Liu, Lauren N Ayton, FLEUR O'hare, JANAN Arslan, Monica L Hu, Alexander P Noar, Jiang-hui Wang, Doron G Hickey, Myra B Mcguinness, Andrea L Vincent, Fred K Chen, Thomas L Edwards

Journal article  |  2022  |  AMERICAN JOURNAL OF OPHTHALMOLOGY

PURPOSE: To evaluate anatomic and functional intereye symmetry among individuals with Bietti crystalline dystrophy (BCD) using cli..

Between-eye symmetry in Bietti crystalline dystrophy

Zhengyang Liu, Lauren N Ayton, Fleur O'Hare, Janan Arslan, Monica L Hu, Jiang-Hui Wang, Doron G Hickey, Myra B McGuinness, Andrea L Vincent, Fred K Chen, Thomas L Edwards

Conference Proceedings  |  2022  |  CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY