Nicole Stupka

Targeting intramuscular adipose tissue expansion to preserve contractile function in volumetric muscle loss: A potentially novel therapy?

Ahmed Al Saedi, Gustavo Duque, Nicole Stupka

Journal article  |  2021  |  CURRENT OPINION IN PHARMACOLOGY

In volumetric muscle loss (VML), the severity of trauma exceeds a muscle's regenerative capacity. VML causes permanent functional ..

1,25(OH)(2)D-3 ameliorates palmitate-induced lipotoxicity in human primary osteoblasts leading to improved viability and function

Ahmed Al Saedi, Damian E Myers, Nicole Stupka, Gustavo Duque

Journal article  |  2020  |  BONE

Contributing to bone loss with aging is a progressive reduction in osteoblast number and function leading to decreased bone format..

Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles

Natasha L McRae, Alex B Addinsall, Kirsten F Howlett, Bryony McNeill, Daniel R McCulloch, Nicole Stupka

Journal article  |  2020  |  SCIENTIFIC REPORTS

There is a persistent, aberrant accumulation of V0/V1 versican in skeletal muscles from patients with Duchenne muscular dystrophy ..

Impaired exercise performance is independent of inflammation and cellular stress following genetic reduction or deletion of selenoprotein S

Alex Bernard Addinsall, Craig Robert Wright, Taryan L Kotsiakos, Zoe M Smith, Taylah R Cook, Sofianos Andrikopoulos, Chris van der Poel, Nicole Stupka

Journal article  |  2020  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Selenoprotein S (Seps1) can be protective against oxidative, endoplasmic reticulum (ER), and inflammatory stress. Seps1 global kno..

Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles

Alex B Addinsall, Leonard G Forgan, Natasha L McRae, Rhys W Kelly, Penny L McDonald, Bryony McNeil, Daniel R McCulloch, Nicole Stupka

Journal article  |  2020  |  BIOMOLECULES

Aberrant extracellular matrix synthesis and remodeling contributes to muscle degeneration and weakness in Duchenne muscular dystro..

Pathogenesis of Osteoporosis

Ahmed Al Saedi, Nicole Stupka, Gustavo Duque

Journal article  |  2020  |  BONE REGULATORS AND OSTEOPOROSIS THERAPY

Osteoporosis is a condition where bone resorption exceeds bone formation leading to degeneration. With an aging population, the pr..

Differential regulation of cellular stress responses by the endoplasmic reticulum-resident Selenoprotein S (Seps1) in proliferating myoblasts versus myotubes

Alex B Addinsall, Sheree D Martin, Fiona Collier, Xavier A Conlan, Victoria C Foletta, Nicole Stupka

Journal article  |  2018  |  PHYSIOLOGICAL REPORTS

The antioxidant Selenoprotein S (Seps1, Selenos) is an endoplasmic reticulum (ER)-resident protein associated with metabolic and i..

Deficiency of selenoprotein S, an endoplasmic reticulum resident oxidoreductase, impairs the contractile function of fast-twitch hindlimb muscles

Alex B Addinsall, Craig R Wright, Chris S Shaw, Natasha L McRae, Leonard G Forgan, Chia-Heng Weng, Xavier A Conlan, Paul S Francis, Zoe M Smith, Sofianos Andrikopoulos, Nicole Stupka

Journal article  |  2018  |  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Selenoprotein S (Seps1) is an endoplasmic reticulum (ER) resident antioxidant implicated in ER stress and inflammation. In human v..

Emerging roles of endoplasmic reticulum-resident selenoproteins in the regulation of cellular stress responses and the implications for metabolic disease

Alex B Addinsall, Craig R Wright, Sof Andrikopoulos, Chris van der Poel, Nicole Stupka

Journal article  |  2018  |  BIOCHEMICAL JOURNAL

Chronic metabolic stress leads to cellular dysfunction, characterized by excessive reactive oxygen species, endoplasmic reticulum ..

Large and Small Assembly: Combining Functional Macromolecules with Small Peptides to Control the Morphology of Skeletal Muscle Progenitor Cells

Rui Li, Natasha L McRae, Daniel R McCulloch, Mitchell Boyd-Moss, Colin J Barrow, David R Nisbet, Nicole Stupka, Richard J Williams

Journal article  |  2018  |  BIOMACROMOLECULES

The material properties of natural tissues, such as skeletal muscle, are highly sophisticated and are synthetically challenging to..