Simon Keam

TP53 Status, Patient Sex, and the Immune Response as Determinants of Lung Cancer Patient Survival

Donald Freudenstein, Cassandra Litchfield, Franco Caramia, Gavin Wright, Benjamin J Solomon, David Ball, Simon P Keam, Paul Neeson, Ygal Haupt, Sue Haupt

Journal article  |  2020  |  Cancers

Lung cancer poses the greatest cancer-related death risk and males have poorer outcomes than females, for unknown reasons. Patient..

A Distinct Pretreatment Immune Gene Signature in Lentigo Maligna Is Associated with Imiquimod Response

Heloise Halse, Franco Caramia, Catriona A McLean, Minyu Wang, Han Xian Aw Yeang, Simon P Keam, Andreas Behren, Lena Ly, Martin Haskett, Jonathan Cebon, Grant A McArthur, Paul J Neeson, Victoria J Mar

Journal article  |  2020  |  Journal of Investigative Dermatology

Lentigo maligna (LM) is a common subtype of in situ melanoma on chronically sun-exposed skin, particularly the head and neck of ol..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Scott Williams, Simon P Keam, Heloise Halse, Nguyen Thu, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Kaur Sandhu, Piers Blombery, Ygal Haupt, Paul J Neeson

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

The tumor immune microenvironment of germline BRCA1/2 and sporadic prostate cancer

Anna S Trigos, Anupama Pasam, Patricia Diana Banks, Roslyn Wallace, Simon P Keam, Heather Thorne, Catherine Mitchell, David Clouston, Declan G Murphy, Nathan Lawrentschuk, Damien M Bolton, Daniel Moon, Elena Castro, David Olmos, Phillip K Darcy, Ygal Haupt, Scott Williams, David L Goode, Paul J Neeson, Shahneen Kaur Sandhu

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

Primary and metastatic breast tumors cross-talk to influence immunotherapy responses

Amanda J Oliver, Simon P Keam, Bianca von Scheidt, Damien J Zanker, Aaron J Harrison, Daniela GM Tantalo, Phillip K Darcy, Michael H Kershaw, Clare Y Slaney

Journal article  |  2020  |  OncoImmunology

The presence of a tumor can alter host immunity systematically. The immune-tumor interaction in one site may impact the local immu..

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Simon P Keam, Heloise Halse, Thu Nguyen, Minyu Wang, Nicolas Van Kooten Losio, Catherine Mitchell, Franco Caramia, David J Byrne, Sue Haupt, Georgina Ryland, Phillip K Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott G Williams, Paul J Neeson

Journal article  |  2020  |  Journal for ImmunoTherapy of Cancer

BACKGROUND: Prostate cancer (PCa) has a profoundly immunosuppressive microenvironment and is commonly immune excluded with few inf..

E6AP Promotes a Metastatic Phenotype in Prostate Cancer

Cristina Gamell, Ivona Bandilovska, Twishi Gulati, Arielle Kogan, Syer Choon Lim, Zaklina Kovacevic, Elena A Takano, Clelia Timpone, Arjelle D Agupitan, Cassandra Litchfield, Giovanni Blandino, Lisa G Horvath, Stephen B Fox, Scott G Williams, Andrea Russo, Enzo Gallo, Piotr J Paul, Catherine Mitchell, Shahneen Sandhu, Simon P Keam, et al.

Journal article  |  2019  |  iScience

Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6A..

Cannibalism in Breast Cancer: The Dangers of Overeating

Sue Haupt, Simon P Keam, Ygal Haupt

Journal article  |  2019  |  Trends in Cancer

Cancer cells devouring their neighbours to survive drug treatment is an abhorrent concept. Yet it holds hope for exploring new ant..

Predicting radiation-induced immune trafficking and activation in localized prostate cancer

Simon Keam, Heloise Halse, Nguyen ThuNgoc, Catherine Mitchell, Franco Caramia, David Byrne, Sue Haupt, Georgina Ryland, Phillip Darcy, Shahneen Sandhu, Piers Blombery, Ygal Haupt, Scott Williams, Paul Neeson

Conference Proceedings  |  2019  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Immune Profiling of Primary Prostate Cancer Arising in Men with and Without Germline DNA Repair Defects

Shahneen Sandhu, Anna Trigos, Anu Pasam, Patricia Banks, Simon Keam, Heather Thorn, Catherine Mitchell, David Clouston, Declan Murphy, Damien Bolton, Phil Darcy, Ygal Haupt, Scot Williams, David Goode, Paul Neeson

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY