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Dr

Debnath Ghosal

Senior Research Fellow
In situ structural biology
Host-pathogen interaction
bacterial proteins
legionella pneumophila
type iv secretion systems
electron microscope tomography
animals
cell division
flagella
Debnath Ghosal's Profile Picture
Dr

Debnath Ghosal

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
In situ structural biology
Debnath Ghosal's Profile Picture
Dr

Debnath Ghosal

 

Dr Debnath Ghosal is a Senior Lecturer and laboratory head in the Department of Biochemistry and Molecular Biology, University of Melbourne at the Bio21 Molecular Science and Biotechnology Institute. His research interest lies in the intricacies of host pathogen interaction particularly, how bacterial and viral pathogens utilize complex molecular machines to cause infection.

Debnath obtained his Master's degree from the Tata Institute of Fundamental Research (Mumbai, India) and subsequently completed his PhD dissertation from the MRC Laboratory of Molecular Biology (University of Cambridge, UK) under the supervision Dr Jan Löwe (FRS). After his PhD, Debnath worked briefly as a career development fellow at the MRC LMB before moving to California Institute of Technology (USA) for his postdoctoral training with Prof Grant Jensen. He has more than ten years of research experience in the areas of structural biology, biochemistry and bacterial cell biology. Debnath joined the University of Melbourne in early 2020. His laboratory utilizes the unique power of cryo-ET and combines it with correlative light and electron microscopy (CLEM), and Focused Ion Beam (FIB) milling to investigate the structure and function of large bacterial macromolecular assemblies and host pathogen interaction. Find out more about us here: http://ghosallab.com/

Scholarly Works

Displaying the 19 most recent scholarly works by Debnath Ghosal.

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Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography.

Debnath Ghosal, Ki Woo Kim, Huaixin Zheng, Mohammed Kaplan, Hilary K Truchan, Alberto E Lopez, Ian E McIntire, Joseph P Vogel, Nicholas P Cianciotto, Grant J Jensen

Journal article  |  2020  |  Nature Microbiology

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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In vivo structure of the Legionella type II secretion system by electron cryotomography.

Debnath Ghosal, Ki Woo Kim, Huaixin Zheng, Mohammed Kaplan, Hilary K Truchan, Alberto E Lopez, Ian E McIntire, Joseph P Vogel, Nicholas P Cianciotto, Grant J Jensen

Journal article  |  2019  |  Nature Microbiology

The type II secretion system (T2SS) is a multiprotein envelope-spanning assembly that translocates a wide range of virulence facto..

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In situ imaging of the bacterial flagellar motor disassembly and assembly processes.

Mohammed Kaplan, Poorna Subramanian, Debnath Ghosal, Catherine M Oikonomou, Sahand Pirbadian, Ruth Starwalt-Lee, Shrawan Kumar Mageswaran, Davi R Ortega, Jeffrey A Gralnick, Mohamed Y El-Naggar, Grant J Jensen

Journal article  |  2019  |  The EMBO Journal

The self-assembly of cellular macromolecular machines such as the bacterial flagellar motor requires the spatio-temporal synchroni..

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Molecular architecture, polar targeting and biogenesis of the Legionella Dot/Icm T4SS.

Debnath Ghosal, Kwangcheol C Jeong, Yi-Wei Chang, Jacob Gyore, Lin Teng, Adam Gardner, Joseph P Vogel, Grant J Jensen

Journal article  |  2019  |  Nature Microbiology

Legionella pneumophila survives and replicates inside host cells by secreting ~300 effectors through the defective in organelle tr..

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The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type.

Mohammed Kaplan, Debnath Ghosal, Poorna Subramanian, Catherine M Oikonomou, Andreas Kjaer, Sahand Pirbadian, Davi R Ortega, Ariane Briegel, Mohamed Y El-Naggar, Grant J Jensen

Journal article  |  2019  |  eLife

The bacterial flagellar motor, a cell-envelope-embedded macromolecular machine that functions as a cellular propeller, exhibits si..

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In Situ Imaging and Structure Determination of Bacterial Toxin Delivery Systems Using Electron Cryotomography.

Debnath Ghosal, Mohammed Kaplan, Yi-Wei Chang, Grant J Jensen

Book Chapter  |  2019  |  Methods in Molecular Biology

Determining the three-dimensional structure of biomacromolecules at high resolution in their native cellular environment is a majo..

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In Vivo Structures of the Helicobacter pylori cag Type IV Secretion System.

Yi-Wei Chang, Carrie L Shaffer, Lee A Rettberg, Debnath Ghosal, Grant J Jensen

Journal article  |  2018  |  Cell Reports

The type IV secretion system (T4SS) is a versatile nanomachine that translocates diverse effector molecules between microbes and i..

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Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis.

Ariane Briegel, Catherine M Oikonomou, Yi-Wei Chang, Andreas Kjær, Audrey N Huang, Ki Woo Kim, Debnath Ghosal, Hong H Nguyen, Dorothy Kenny, Rachel R Ogorzalek Loo, Robert P Gunsalus, Grant J Jensen

Journal article  |  2017  |  EMBO reports

Archaeal swimming motility is driven by archaella: rotary motors attached to long extracellular filaments. The structure of these ..

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Polar delivery of Legionella type IV secretion system substrates is essential for virulence.

Kwangcheol C Jeong, Debnath Ghosal, Yi-Wei Chang, Grant J Jensen, Joseph P Vogel

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

A recurrent emerging theme is the targeting of proteins to subcellular microdomains within bacterial cells, particularly to the po..

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Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis.

Qing Yao, Andrew I Jewett, Yi-Wei Chang, Catherine M Oikonomou, Morgan Beeby, Cristina V Iancu, Ariane Briegel, Debnath Ghosal, Grant J Jensen

Journal article  |  2017  |  The EMBO Journal

FtsZ, the bacterial homologue of eukaryotic tubulin, plays a central role in cell division in nearly all bacteria and many archaea..

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In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography.

Debnath Ghosal, Yi-Wei Chang, Kwangcheol C Jeong, Joseph P Vogel, Grant J Jensen

Journal article  |  2017  |  EMBO reports

Type IV secretion systems (T4SSs) are large macromolecular machines that translocate protein and DNA and are involved in the patho..

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The C-terminal tails of heterotrimeric kinesin-2 motor subunits directly bind to α-tubulin1: Possible implications for cilia-specific tubulin entry.

Mukul Girotra, Shalini Srivastava, Anuttama Kulkarni, Ayan Barbora, Kratika Bobra, Debnath Ghosal, Pavithra Devan, Amol Aher, Akanksha Jain, Dulal Panda, Krishanu Ray

Journal article  |  2017  |  Traffic

The assembly of microtubule-based cytoskeleton propels the cilia and flagella growth. Previous studies have indicated that the kin..

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FtsZ-ring Architecture and Its Control by MinCD.

Piotr Szwedziak, Debnath Ghosal

Journal article  |  2017  |  Sub-Cellular Biochemistry

In bacteria and archaea, the most widespread cell division system is based on the tubulin homologue FtsZ protein, whose filaments ..

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Bacterial and Archaeal Cytoskeletons

D Ghosal, J Löwe, LA Amos

Book Chapter  |  2016

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Collaborative protein filaments

Debnath Ghosal, Jan Loewe

Journal article  |  2015  |  The EMBO Journal

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MinCD cell division proteins form alternating copolymeric cytomotive filaments

Debnath Ghosal, Daniel Trambaiolo, Linda A Amos, Jan Loewe

Conference Proceedings  |  2014  |  Nature Communications

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Interaction with a Kinesin-2 Tail Propels Choline Acetyltransferase Flow Towards Synapse

Aparna Sadananda, Runa Hamid, Harinath Doodhi, Debnath Ghosal, Mukul Girotra, Swadhin Chandra Jana, Krishanu Ray

Journal article  |  2012  |  Traffic

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KAP, the Accessory Subunit of Kinesin-2, Binds the Predicted Coiled-Coil Stalk of the Motor Subunits

Harinath Doodhi, Debnath Ghosal, Mahalakshmi Krishnamurthy, Swadhin C Jana, Divya Shamala, Anirban Bhaduri, R Sowdhamini, Krishanu Ray

Journal article  |  2009  |  Biochemistry

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Structure of the bacterial cellulose ribbon and its assembly-guiding cytoskeleton by electron cryotomography

William J Nicolas, Debnath Ghosal, Elitza I Tocheva, Elliot M Meyerowitz, Grant J Jensen

Journal article

AbstractCellulose is a widespread component of bacterial biofilms, where its properties of exceptional water retention, high tensi..

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Scholarly Works

Keyword Analysis

Biochemistry and Cell Biology
Expanding Knowledge

Credentials

Positions

Senior Research Fellow

Biochemistry And Molecular Biology

Editorial Board Member

Applied Microscopy (https://appmicro.springeropen.com/)

Ambassador, Elife Early-Career Advisory Group

eLife

Editorial Board Member

ScienceMatters (https://www.sciencematters.io/)

Society Secretary

Southern California Society for Microscopy and Microanalysis

Education

Doctor of Philosophy

University of Cambridge

MSc by Research

Tata Institute of Fundamental Research

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