Andrew Hayes

Overcoming bacteriophage insensitivity in Staphylococcus aureus using clindamycin and azithromycinat subinhibitory concentrations.

Sha Liu, Yin Zhao, Andrew Hayes, Karen Hon, Guimin Zhang, Catherine Bennett, Hua Hu, John Finnie, Sandra Morales, Linda Shearwin, Alkis J Psaltis, Keith Shearwin, Peter-John Wormald, Sarah Vreugde

Journal article  |  2021  |  Allergy

BACKGROUND: Staphylococcus aureus is a pathogen of major concern in both acute infections and chronic conditions such as chronic r..

Corynebacterium accolens Has Antimicrobial Activity against Staphylococcus aureus and Methicillin-Resistant S. aureus Pathogens Isolated from the Sinonasal Niche of Chronic Rhinosinusitis Patients

Martha Alemayehu Menberu, Sha Liu, Clare Cooksley, Andrew James Hayes, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2021  |  PATHOGENS

Corynebacterium accolens is the predominant species of the healthy human nasal microbiota, and its relative abundance is decreased..

Tween 80 and its derivative oleic acid promote the growth of Corynebacterium accolens and inhibit Staphylococcus aureus clinical isolates

Martha Alemayehu Menberu, Andrew James Hayes, Sha Liu, Alkis James Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2020  |  INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

Andrew J Hayes, Jiulia Satiaputra, Louise M Sternicki, Ashleigh S Paparella, Zikai Feng, Kwang J Lee, Beatriz Blanco-Rodriguez, William Tieu, Bart A Eijkelkamp, Keith E Shearwin, Tara L Pukala, Andrew D Abell, Grant W Booker, Steven W Polyak

Journal article  |  2020  |  ANTIBIOTICS-BASEL

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant S..

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article  |  2020  |  MSPHERE

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding pr..

Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion

Hua Hu, Mahnaz Ramezanpour, Andrew J Hayes, Sha Liu, Alkis J Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2019  |  JOURNAL OF CLINICAL MEDICINE

BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a chronic inflammation of the nose and paranasal sinus mucosa associated wi..

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Kwang Jun Lee, William Tieu, Beatriz Blanco-Rodriguez, Ashleigh S Paparella, Jingxian Yu, Andrew Hayes, Jiage Feng, Andrew C Marshall, Benjamin Noll, Robert Milne, Danielle Cini, Matthew CJ Wilce, Grant W Booker, John B Bruning, Steven W Polyak, Andrew D Abell

Journal article  |  2019  |  ACS CHEMICAL BIOLOGY

Here, we report the design, synthesis, and evaluation of a series of inhibitors of Staphylococcus aureus BPL (SaBPL), where the ce..

Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus

Jiulia Satiaputra, Louise M Sternicki, Andrew J Hayes, Tara L Pukala, Grant W Booker, Keith E Shearwin, Steven W Polyak

Journal article  |  2019  |  SCIENTIFIC REPORTS

An adequate supply of biotin is vital for the survival and pathogenesis of Staphylococcus aureus. The key protein responsible for ..

Staphylococcus aureus small colony variants: Prevalence in chronic rhinosinusitis and induction by antibiotics

Guimin Zhang, Yin Zhao, Andrew J Hayes, Alkis J Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2018  |  ALLERGY

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Ashleigh S Paparella, Kwang Jun Lee, Andrew J Hayes, Jiage Feng, Zikai Feng, Danielle Cini, Sonali Deshmukh, Grant W Booker, Matthew CJ Wilce, Steven W Polyak, Andrew D Abell

Journal article  |  2018  |  ACS Infect Dis

We report the synthesis and evaluation of 5-halogenated-1,2,3-triazoles as inhibitors of biotin protein ligase from Staphylococcus..