Andrew Hayes

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase

Andrew J Hayes, Jiulia Satiaputra, Louise M Sternicki, Ashleigh S Paparella, Zikai Feng, Kwang J Lee, Beatriz Blanco-Rodriguez, William Tieu, Bart A Eijkelkamp, Keith E Shearwin, Tara L Pukala, Andrew D Abell, Grant W Booker, Steven W Polyak

Journal article  |  2020  |  Antibiotics

Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant S..

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins

Andrew Hayes, Jake A Lacey, Jacqueline M Morris, Mark R Davies, Steven YC Tong

Journal article  |  2020  |  mSphere

A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding pr..

Sub-Inhibitory Clindamycin and Azithromycin reduce S. aureus Exoprotein Induced Toxicity, Inflammation, Barrier Disruption and Invasion

Hua Hu, Mahnaz Ramezanpour, Andrew J Hayes, Sha Liu, Alkis J Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2019  |  Journal of Clinical Medicine

BACKGROUND: Chronic rhinosinusitis (CRS) is defined as a chronic inflammation of the nose and paranasal sinus mucosa associated wi..

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

Kwang Jun Lee, William Tieu, Beatriz Blanco-Rodriguez, Ashleigh S Paparella, Jingxian Yu, Andrew Hayes, Jiage Feng, Andrew C Marshall, Benjamin Noll, Robert Milne, Danielle Cini, Matthew CJ Wilce, Grant W Booker, John B Bruning, Steven W Polyak, Andrew D Abell

Journal article  |  2019  |  ACS Chemical Biology

Native mass spectrometry identifies an alternative DNA-binding pathway for BirA from Staphylococcus aureus

Jiulia Satiaputra, Louise M Sternicki, Andrew J Hayes, Tara L Pukala, Grant W Booker, Keith E Shearwin, Steven W Polyak

Journal article  |  2019  |  Scientific Reports

Staphylococcus aureus small colony variants: Prevalence in chronic rhinosinusitis and induction by antibiotics

Guimin Zhang, Yin Zhao, Andrew J Hayes, Alkis J Psaltis, Peter-John Wormald, Sarah Vreugde

Journal article  |  2018  |  Allergy

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus

Ashleigh S Paparella, Kwang Jun Lee, Andrew J Hayes, Jiage Feng, Zikai Feng, Danielle Cini, Sonali Deshmukh, Grant W Booker, Matthew CJ Wilce, Steven W Polyak, Andrew D Abell

Journal article  |  2018  |  ACS Infectious Diseases

New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase

Jiage Feng, Ashleigh S Paparella, William Tieu, David Heim, Sarah Clark, Andrew Hayes, Grant W Booker, Steven W Polyak, Andrew D Abell

Journal article  |  2016  |  ACS Medicinal Chemistry Letters