Yan Tan

A therapeutic Porphyromonas gingivalis gingipain vaccine induces neutralising IgG1 antibodies that protect against experimental periodontitis

Neil M O'Brien-Simpson, James A Holden, Jason C Lenzo, Yan Tan, Gail C Brammar, Katrina A Walsh, William Singleton, Rebecca KH Orth, Nada Slakeski, Keith J Cross, Ivan B Darby, Dorit Becher, Tony Rowe, Adriana Baz Morelli, Andrew Hammet, Andrew Nash, Anna Brown, Bing Ma, Didier Vingadassalom, Jacqueline McCluskey, et al.

Journal article  |  2016  |  NPJ VACCINES

Porphyromonas gingivalis infected mice with an established P. gingivalis-specific inflammatory immune response were protected from..

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model

Roselind S Lam, Neil M O'Brien-Simpson, John A Hamilton, Jason C Lenzo, James A Holden, Gail C Brammar, Rebecca K Orth, Yan Tan, Katrina A Walsh, Andrew J Fleetwood, Eric C Reynolds

Journal article  |  2015  |  IMMUNOLOGY AND CELL BIOLOGY

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and urokinase-type plasminogen activator (uPA) can contribute to the pro..

The Porphyromonas gingivalis Ferric Uptake Regulator Orthologue Binds Hemin and Regulates Hemin-Responsive Biofilm Development

Catherine A Butler, Stuart G Dashper, Lianyi Zhang, Christine A Seers, Helen L Mitchell, Deanne V Catmull, Michelle D Glew, Jacqueline E Heath, Yan Tan, Hasnah SG Khan, Eric C Reynolds

Journal article  |  2014  |  PLOS ONE

Porphyromonas gingivalis is a Gram-negative pathogen associated with the biofilm-mediated disease chronic periodontitis. P. gingiv..

Outer Membrane Proteome and Antigens of Tannerella forsythia

Paul D Veith, Neil M O'Brien-Simpson, Yan Tan, Deasy C Djatmiko, Stuart G Dashper, Eric C Reynolds

Journal article  |  2009  |  JOURNAL OF PROTEOME RESEARCH

Tannerella forsythia is a Gram-negative, anaerobic, fusiform bacterium implicated as a periodontal pathogen. With use of 2D PAGE, ..

Rotavirus infection accelerates type 1 diabetes in mice with established insulitis

Kate L Graham, Natalie Sanders, Yan Tan, Janette Allison, Thomas WH Kay, Barbara S Coulson

Journal article  |  2008  |  JOURNAL OF VIROLOGY

Infection modulates type 1 diabetes, a common autoimmune disease characterized by the destruction of insulin-producing islet beta ..

Rotavirus infection of infant and young adult nonobese diabetic mice involves extraintestinal spread and delays diabetes onset

Kate L Graham, Joanne A O'Donnell, Yan Tan, Natalie Sanders, Emma M Carrington, Janette Allison, Barbara S Coulson

Journal article  |  2007  |  JOURNAL OF VIROLOGY

Rotaviruses have been implicated as a possible viral trigger for exacerbations in islet autoimmunity, suggesting they might modula..