Susanne Ramm

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologo..

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M Winter, Luke A Selth, Amy R Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E Hickey, Wayne D Tilley, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence, Kaylene J Simpson

Journal article  |  2021  |  SLAS DISCOVERY

New treatments are required for advanced prostate cancer; however, there are fewer preclinical models of prostate cancer than othe..

Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease

Kevin A Lidberg, Andrew J Annalora, Marija Jozic, Daniel J Elson, Lu Wang, Theo K Bammler, Susanne Ramm, Maria Beatriz Monteiro, Jonathan Himmelfarb, Craig B Marcus, Patrick L Iversen, Edward J Kelly

Journal article  |  2021  |  SCIENTIFIC REPORTS

CYP3A5 is the primary CYP3A subfamily enzyme expressed in the human kidney and its aberrant expression may contribute to a broad s..

A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death

Sophia Ceder, Sofi E Eriksson, Emarndeena H Cheteh, Swati Dawar, Mariana Corrales Benitez, Vladimir JN Bykov, Kenji M Fujihara, Melodie Grandin, Xiaodun Li, Susanne Ramm, Corina Behrenbruch, Kaylene J Simpson, Frederic Hollande, Lars Abrahmsen, Nicholas J Clemons, Klas G Wiman

Journal article  |  2020  |  EMBO MOLECULAR MEDICINE

The tumor suppressor gene TP53 is the most frequently mutated gene in cancer. The compound APR-246 (PRIMA-1Met/Eprenetapopt) is co..

CDK4/6 inhibition triggers anti-tumour immunity

Shom Goel, Molly J DeCristo, April C Watt, Haley BrinJones, Jaclyn Sceneay, Ben B Li, Naveed Khan, Jessalyn M Ubellacker, Shaozhen Xie, Otto Metzger-Filho, Jeremy Hoog, Matthew J Ellis, Cynthia X Ma, Susanne Ramm, Ian E Krop, Eric P Winer, Thomas M Roberts, Hye-Jung Kim, Sandra S McAllister, Jean J Zhao

Journal article  |  2017  |  NATURE

Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progre..

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

Shom Goel, Qi Wang, April C Watt, Sara M Tolaney, Deborah A Dillon, Wei Li, Susanne Ramm, Adam C Palmer, Haluk Yuzugullu, Vinay Varadan, David Tuck, Lyndsay N Harris, Kwok-Kin Wong, X Shirley Liu, Piotr Sicinski, Eric P Winer, Ian E Krop, Jean J Zhao

Journal article  |  2016  |  CANCER CELL

Using transgenic mouse models, cell line-based functional studies, and clinical specimens, we show that cyclin D1/CDK4 mediate res..