Shadi Maghool

Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly

Luke E Formosa, Shadi Maghool, Alice J Sharpe, Boris Reljic, Linden Muellner-Wong, David A Stroud, Michael T Ryan, Megan J Maher

Journal article  |  2022  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytochrome c oxidase (COX) assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitocho..

Structural and Functional Investigation of the Periplasmic Arsenate-Binding Protein ArrX from Chrysiogenes arsenatis

Nilakhi Poddar, Consuelo Badilla, Shadi Maghool, Thomas H Osborne, Joanne M Santini, Megan J Maher

Journal article  |  2021  |  BIOCHEMISTRY

The anaerobic bacterium Chrysiogenes arsenatis respires using the oxyanion arsenate (AsO43-) as the terminal electron acceptor, wh..

What Role Does COA6 Play in Cytochrome C Oxidase Biogenesis: A Metallochaperone or Thiol Oxidoreductase, or Both?

Shadi Maghool, Michael T Ryan, Megan J Maher

Journal article  |  2020  |  International Journal of Molecular Sciences

Complex IV (cytochrome c oxidase; COX) is the terminal complex of the mitochondrial electron transport chain. Copper is essential ..

Human glutaredoxin-1 can transfer copper to isolated metal binding domains of the P1B-type ATPase, ATP7B.

Shadi Maghool, Sharon La Fontaine, Blaine R Roberts, Ann H Kwan, Megan J Maher

Journal article  |  2020  |  Scientific Reports

Intracellular copper (Cu) in eukaryotic organisms is regulated by homeostatic systems, which rely on the activities of soluble met..

Structural and functional characterization of the mitochondrial complex IV assembly factor Coa6

Shadi Maghool, N Dinesha G Cooray, David A Stroud, David Aragao, Michael T Ryan, Megan J Maher

Journal article  |  2019  |  LIFE SCIENCE ALLIANCE

Assembly factors play key roles in the biogenesis of many multi-subunit protein complexes regulating their stability, activity, an..

High-resolution crystal structure of the reduced Grx1 from Saccharomyces cerevisiae

Shadi Maghool, Sharon La Fontaine, Megan J Maher

Journal article  |  2019  |  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

Grx1, a cytosolic thiol-disulfide oxidoreductase, actively maintains cellular redox homeostasis using glutathione substrates (redu..

The structural biology of mitochondrial respiratory complex assembly

Megan Maher, Shadi Maghool, Anuradha Herath, Saumya Udagedara, David Dougan, David Stroud, Michael Ryan, Kaye Truscott

Journal article  |  2018  |  Acta Crystallographica Section A Foundations and Advances