Benjamin Blyth

ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol.

Fiona Hegi-Johnson, Stacey E Rudd, Christian Wichmann, Tim Akhurst, Peter Roselt, Jenny Trinh, Thomas John, Lisa Devereux, Paul S Donnelly, Rod Hicks, Andrew M Scott, Daniel Steinfort, Stephen Fox, Benjamin Blyth, Sagun Parakh, Gerard G Hanna, Jason Callahan, Kate Burbury, Michael MacManus

Journal article  |  2022  |  BMJ Open

BACKGROUND: ImmunoPET is a multicentre, single arm, phase 0-1 study that aims to establish if 89Zr-durvalumab PET/CT can be used t..

Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

Anna Sofia Trigos, Anupama Pasam, Patricia Banks, Roslyn Wallace, Christina Guo, Simon Keam, Heather Thorne, Catherine Mitchell, Stephen Lade, David Clouston, Alexander Hakansson, Yang Liu, Benjamin Blyth, Declan Murphy, Nathan Lawrentschuk, Damien Bolton, Daniel Moon, Phil Darcy, Ygal Haupt, Scott G Williams, et al.

Journal article  |  2022  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treat..

Imaging immunity in patients with cancer using positron emission tomography

Fiona Hegi-Johnson, Stacey Rudd, Rodney J Hicks, Dirk De Ruysscher, Joseph A Trapani, Thomas John, Paul Donnelly, Benjamin Blyth, Gerard Hanna, Sarah Everitt, Peter Roselt, Michael P MacManus

Journal article  |  2022  |  NPJ PRECISION ONCOLOGY

Immune checkpoint inhibitors and related molecules can achieve tumour regression, and even prolonged survival, for a subset of can..

Post-Irradiation Thymic Regeneration in B6C3F1 Mice Is Age Dependent and Modulated by Activation of the PI3K-AKT-mTOR Pathway

Masaaki Sunaoshi, Benjamin J Blyth, Yi Shang, Chizuru Tsuruoka, Takamitsu Morioka, Mayumi Shinagawa, Mari Ogawa, Yoshiya Shimada, Akira Tachibana, Daisuke Iizuka, Shizuko Kakinuma

Journal article  |  2022  |  BIOLOGY-BASEL

The risk of radiation-induced carcinogenesis depends on age at exposure. We previously reported principal causative genes in lymph..

Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF(V600) melanoma

Lorey K Smith, Tiffany Parmenter, Margarete Kleinschmidt, Eric P Kusnadi, Jian Kang, Claire A Martin, Peter Lau, Riyaben Patel, Julie Lorent, David Papadopoli, Anna Trigos, Teresa Ward, Aparna D Rao, Emily J Lelliott, Karen E Sheppard, David Goode, Rodney J Hicks, Tony Tiganis, Kaylene J Simpson, Ola Larsson, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

Despite the success of therapies targeting oncogenes in cancer, clinical outcomes are limited by residual disease that ultimately ..

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Therapeutic Efficacy of a Bivalent Inhibitor of Prostate-Specific Membrane Antigen Labeled with( 67)Cu

Lachlan E McInnes, Carleen Cullinane, Peter D Roselt, Susan Jackson, Benjamin J Blyth, Ellen M van Dam, Nicholas A Zia, Matthew J Harris, Rodney J Hicks, Paul S Donnelly

Journal article  |  2021  |  JOURNAL OF NUCLEAR MEDICINE

Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) is promising for prostate cancer. We previously reported ..

A Deep Learning Model to Automate Skeletal Muscle Area Measurement on Computed Tomography Images

Kaushalya C Amarasinghe, Jamie Lopes, Julian Beraldo, Nicole Kiss, Nicholas Bucknell, Sarah Everitt, Price Jackson, Cassandra Litchfield, Linda Denehy, Benjamin J Blyth, Shankar Siva, Michael MacManus, David Ball, Jason Li, Nicholas Hardcastle

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

BACKGROUND: Muscle wasting (Sarcopenia) is associated with poor outcomes in cancer patients. Early identification of sarcopenia ca..

Structure-activity relationship study of peptide Gastramide-01 (GA-01), a potent binder of cholecystokinin-2 (CCK-2) receptor and theranostic candidate

Marwa Rahimi, Alicia Corlett, Jessica Van Zuylekom, Benjamin Blyth, Philip Thompson, Mohammad Haskali

Conference Proceedings  |  2021  |  NUCLEAR MEDICINE AND BIOLOGY

Next generation therapeutic radiopharmaceuticals targeting cholecystokinin-2 receptor positive cancers

Alicia Corlett, Jessica Van Zuylekom, Benjamin Blyth, Mohammad Haskali

Conference Proceedings  |  2021  |  NUCLEAR MEDICINE AND BIOLOGY