Benjamin Blyth

Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state

Maria Gomolka, Benjamin Blyth, Michel Bourguignon, Christophe Badie, Annette Schmitz, Christopher Talbot, Christoph Hoeschen, Sisko Salomaa

Journal article  |  2019  |  International Journal of Radiation Biology

Purpose: The workshop on 'Individual Radiosensitivity and Radiosusceptibility' organized by MELODI and CONCERT on Malta in 2018, e..

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Takamitsu Morioka, Benjamin J Blyth, Tatsuhiko Imaoka, Mayumi Nishimura, Hiroshi Takeshita, Takeo Shimomura, Jun Ohtake, Atsuro Ishida, Paul Schofield, Bernd Grosche, Ulrike Kulka, Yoshiya Shimada, Yutaka Yamada, Shizuko Kakinuma

Journal article  |  2019  |  International Journal of Radiation Biology

Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Tech..

Differential effect of parity on rat mammary carcinogenesis after pre- or post-pubertal exposure to radiation

Masaru Takabatake, Kazuhiro Daino, Tatsuhiko Imaoka, Benjamin J Blyth, Toshiaki Kokubo, Yukiko Nishimura, Kaye Showler, Ayaka Hosoki, Hitomi Moriyama, Mayumi Nishimura, Shizuko Kakinuma, Masahiro Fukushi, Yoshiya Shimada

Journal article  |  2018  |  Scientific Reports

Radiation exposure during the peri-pubertal period is a proven risk factor for breast cancer, whereas parity is an established pro..

Radiation therapy-induced metastasis: radiobiology and clinical implications

Benjamin J Blyth, Aidan J Cole, Michael P MacManus, Olga A Martin

Journal article  |  2018  |  Clinical & Experimental Metastasis

The paradox of adaptive responses and iso-effect per fraction The history of dose fractionation symposium: September 2015, RRS annual meeting

Benjamin J Blyth

Journal article  |  2018  |  International Journal of Radiation Biology

PURPOSE: Despite decades of research into radiation-induced adaptive responses, where prior irradiation changes the response to su..

Clinical and Functional Assays of Radiosensitivity and Radiation-Induced Second Cancer

Mohammad Habash, Luis C Bohorquez, Elizabeth Kyriakou, Tomas Kron, Olga A Martin, Benjamin J Blyth

Journal article  |  2017  |  Cancers

Tissue-specific and time-dependent clonal expansion of ENU-induced mutant cells in gpt delta mice.

Takafumi Nakayama, Tomoko Sawai, Ikuko Masuda, Shinya Kaneko, Kazumi Yamauchi, Benjamin J Blyth, Yoshiya Shimada, Akira Tachibana, Shizuko Kakinuma

Journal article  |  2017  |  Environmental and Molecular Mutagenesis

DNA mutations play a crucial role in the origins of cancer, and the clonal expansion of mutant cells is one of the fundamental ste..

Radiation Exposure Enhances Hepatocyte Proliferation in Neonatal Mice but not in Adult Mice.

Yi Shang, Yurika Sawa, Benjamin J Blyth, Chizuru Tsuruoka, Hiroyuki Nogawa, Yoshiya Shimada, Shizuko Kakinuma

Journal article  |  2017  |  Radiation Research

There is a natural tendency to expect that irradiation of an infant organ prior to development-related expansion will result in a ..

Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas.

Kaye Showler, Mayumi Nishimura, Kazuhiro Daino, Tatsuhiko Imaoka, Yukiko Nishimura, Takamitsu Morioka, Benjamin J Blyth, Toshiaki Kokubo, Masaru Takabatake, Maki Fukuda, Hitomi Moriyama, Shizuko Kakinuma, Masahiro Fukushi, Yoshiya Shimada

Journal article  |  2017  |  Journal of Radiation Research

The PI3K/AKT pathway is one of the most important signaling networks in human breast cancer, and since it was potentially implicat..

Effect of Age at Exposure on the Incidence of Lung and Mammary Cancer after Thoracic X-Ray Irradiation in Wistar Rats.

Yutaka Yamada, Ken-Ichi Iwata, Benjamin J Blyth, Kazutaka Doi, Takamitsu Morioka, Kazuhiro Daino, Mayumi Nishimura, Shizuko Kakinuma, Yoshiya Shimada

Journal article  |  2017  |  Radiation Research

Epidemiology studies have shown that children are at greater overall risk of radiation-induced cancer, but the modifying effect of..

DNA Methylation Patterns in Rat Mammary Carcinomas Induced by Pre- and Post-Pubertal Irradiation

Masaru Takabatake, Benjamin J Blyth, Kazuhiro Daino, Tatsuhiko Imaoka, Mayumi Nishimura, Masahiro Fukushi, Yoshiya Shimada

Journal article  |  2016  |  PLOS ONE

Several lines of evidence indicate one's age at exposure to radiation strongly modifies the risk of radiation-induced breast cance..

Sensitive Detection of Radiation-Induced Medulloblastomas after Acute or Protracted Gamma-Ray Exposures in Ptch1 Heterozygous Mice Using a Radiation-Specific Molecular Signature.

Chizuru Tsuruoka, Benjamin J Blyth, Takamitsu Morioka, Mutsumi Kaminishi, Mayumi Shinagawa, Yoshiya Shimada, Shizuko Kakinuma

Journal article  |  2016  |  Radiation Research

Recently reported studies have led to a heightened awareness of the risks of cancer induced by diagnostic radiological imaging, an..

Temporal Responses to X-Radiation Exposure in Spleen in the pKZ1 Mouse Recombination Assay.

Rebecca J Ormsby, Alexander H Staudacher, Benjamin J Blyth, Eva Bezak, Pamela J Sykes

Journal article  |  2016  |  Radiation Research

The in vivo mouse transgenic pKZ1 chromosomal inversion assay is a sensitive assay that responds to very low doses of DNA-damaging..

Interaction of Low-Dose Radiation and Chemicals in Cancer Risk

S Kakinuma, BJ Blyth, Y Shimada

Book Chapter  |  2016

Optimised paediatric CT dose at a tertiary children's hospital in Japan: a 4-y single-centre analysis.

Y Nakada, M Fujiwara, M Yakami, T Yokoyama, A Shirayama, H Yamamoto, K Nabatame, S Obara, K Akahane, BJ Blyth, O Miyazaki, H Date, K Yagi, A Hoshioka, Y Shimada

Journal article  |  2016  |  Radiation Protection Dosimetry

Since diagnostic reference levels (DRLs) for children are not currently established in Japan, the authors determined local DRLs fo..

Cellular localization of uranium in the renal proximal tubules during acute renal uranium toxicity

Shino Homma-Takeda, Keisuke Kitahara, Kyoko Suzuki, Benjamin J Blyth, Noriyoshi Suya, Teruaki Konishi, Yasuko Terada, Yoshiya Shimada

Journal article  |  2015  |  Journal of Applied Toxicology

Renal toxicity is a hallmark of uranium exposure, with uranium accumulating specifically in the S3 segment of the proximal tubules..

The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas

Masaaki Sunaoshi, Yoshiko Amasaki, Shinobu Hirano-Sakairi, Benjamin J Blyth, Takamitsu Morioka, Mutsumi Kaminishi, Yi Shang, Mayumi Nishimura, Yoshiya Shimada, Akira Tachibana, Shizuko Kakinuma

Journal article  |  2015  |  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associa..

Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy

Benjamin J Blyth, Shizuko Kakinuma, Masaaki Sunaoshi, Yoshiko Amasaki, Shinobu Hirano-Sakairi, Kanae Ogawa, Ayana Shirakami, Yi Shang, Chizuru Tsuruoka, Mayumi Nishimura, Yoshiya Shimada

Journal article  |  2015  |  PLOS ONE

Monitoring mice exposed to carbon ion radiotherapy provides an indirect method to evaluate the potential for second cancer inducti..

Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice

Takamitsu Morioka, Tomoko Miyoshi-Imamura, Benjamin J Blyth, Mutsumi Kaminishi, Toshiaki Kokubo, Mayumi Nishimura, Seiji Kito, Yutaka Tokairin, Shusuke Tani, Kimiko Murakami-Murofushi, Naoki Yoshimi, Yoshiya Shimada, Shizuko Kakinuma

Journal article  |  2015  |  Cancer Science

Genetic, physiological and environmental factors are implicated in colorectal carcinogenesis. Mutations in the mutL homolog 1 (MLH..

A single whole-body low dose X-irradiation does not affect L1, B1 and IAP repeat element DNA methylation longitudinally

Michelle R Newman, Pamela J Sykes, Benjamin J Blyth, Eva Bezak, Mark D Lawrence, Katherine L Morel, Rebecca J Ormsby

Journal article  |  2014  |  PLoS ONE

The low dose radioadaptive response has been shown to be protective against high doses of radiation as well as aging-induced genom..

Protection from radiation-induced apoptosis by the radioprotector amifostine (WR-2721) is radiation dose dependent

Rebecca J Ormsby, Mark D Lawrence, Benjamin J Blyth, Katrina Bexis, Eva Bezak, Jeffrey S Murley, David J Grdina, Pamela J Sykes

Journal article  |  2014  |  Cell Biology and Toxicology

The radioprotective agent amifostine is a free radical scavenger that can protect cells from the damaging effects of ionising radi..

The Methylation of DNA Repeat Elements is Sex-Dependent and Temporally Different in Response to X Radiation in Radiosensitive and Radioresistant Mouse Strains

Michelle R Newman, Pamela J Sykes, Benjamin J Blyth, Eva Bezak, Mark D Lawrence, Katherine L Morel, Rebecca J Ormsby

Journal article  |  2014  |  Radiation Research

The effects of ionizing radiation on DNA methylation are of importance due to the role that DNA methylation plays in maintaining g..

Lack of High-Dose Radiation Mediated Prostate Cancer Promotion and Low-Dose Radiation Adaptive Response in the TRAMP Mouse Model

MD Lawrence, RJ Ormsby, BJ Blyth, E Bezak, G England, MR Newman, WD Tilley, PJ Sykes

Journal article  |  2013  |  Radiation Research

False-positive TUNEL staining observed in SV40 based transgenic murine prostate cancer models

MD Lawrence, BJ Blyth, RJ Ormsby, WD Tilley, PJ Sykes

Journal article  |  2013  |  Transgenic Research

Uranium dynamics and developmental sensitivity in rat kidney

Shino Homma-Takeda, Toshiaki Kokubo, Yasuko Terada, Kyoko Suzuki, Shunji Ueno, Tatsuo Hayao, Tatsuya Inoue, Keisuke Kitahara, Benjamin J Blyth, Mayumi Nishimura, Yoshiya Shimada

Journal article  |  2013  |  Journal of Applied Toxicology

Renal toxicity is the principal health concern after uranium exposure. Children are particularly vulnerable to uranium exposure; w..

Co-operative effects of thoracic X-ray irradiation and N-nitrosobis(2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats

Ken-ichi Iwata, Yutaka Yamada, Akifumi Nakata, Yoichi Oghiso, Shusuke Tani, Kazutaka Doi, Takamitsu Morioka, Benjamin J Blyth, Mayumi Nishimura, Shizuko Kakinuma, Yoshiya Shimada

Journal article  |  2013  |  Toxicology and Applied Pharmacology

Assessment of risks associated with childhood exposure to ionizing radiation when combined with chemical carcinogens is of great i..

Sensitive quantitative analysis of murine LINE1 DNA methylation using high resolution melt analysis

Michelle R Newman, Benjamin J Blyth, Damian J Hussey, Daniel Jardine, Pamela J Sykes, Rebecca J Ormsby

Journal article  |  2012  |  Epigenetics

We present here the first high resolution melt (HRM) assay to quantitatively analyze differences in murine DNA methylation levels ..

Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures?

Benjamin J Blyth, Pamela J Sykes

Journal article  |  2011  |  Radiation Research

The term radiation-induced bystander effect is used to describe radiation-induced biological changes that manifest in unirradiated..

If Bystander Effects for Apoptosis Occur in Spleen after Low-Dose Irradiation In Vivo then the Magnitude of the Effect Falls within the Range of Normal Homeostatic Apoptosis

Alexander H Staudacher, Benjamin J Blyth, Mark D Lawrence, Rebecca J Ormsby, Eva Bezak, Pamela J Sykes

Journal article  |  2010  |  Radiation Research

To test whether bystander effects occur in vivo after low doses of radiation relevant to occupational and population exposure, we ..

An Adoptive Transfer Method to Detect Low-Dose Radiation-Induced Bystander Effects In Vivo

Benjamin J Blyth, Edouard I Azzam, Roger W Howell, Rebecca J Ormsby, Alexander H Staudacher, Pamela J Sykes

Journal article  |  2010  |  Radiation Research

The potential for irradiated cells to induce biological effects in their unirradiated neighbors (known as the bystander effect) ha..

Low doses of amifostine protect from chromosomal inversions in spleen in vivo when administered after an occupationally relevant X-radiation dose

AM Hooker, DJ Grdina, JS Murley, BJ Blyth, RJ Ormsby, E Bezak, KA Giam, PJ Sykes

Journal article  |  2009  |  International Journal of Low Radiation

Non-linear chromosomal inversion response in prostate after low dose X-radiation exposure

Guoxin Zeng, Tanya K Day, Antony M Hooker, Benjamin J Blyth, Madhava Bhat, Wayne D Tilley, Pamela J Sykes

Journal article  |  2006  |  Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Somatic intrachromosomal recombination can result in inversions and deletions in DNA, which are important mutations in cancer. The..