Benjamin Blyth

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J Kearney, Jarrod J Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph HA Vissers, Karolina Pavic, Ben P Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, et al.

Journal article  |  2021  |  CELL

Gene expression by RNA polymerase II (RNAPII) is tightly controlled by cyclin-dependent kinases (CDKs) at discrete checkpoints dur..

Therapeutic Efficacy of a Bivalent Inhibitor of Prostate-Specific Membrane Antigen Labeled with( 67)Cu

Lachlan E McInnes, Carleen Cullinane, Peter D Roselt, Susan Jackson, Benjamin J Blyth, Ellen M van Dam, Nicholas A Zia, Matthew J Harris, Rodney J Hicks, Paul S Donnelly

Journal article  |  2021  |  JOURNAL OF NUCLEAR MEDICINE

Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) is promising for prostate cancer. We previously reported ..

A Deep Learning Model to Automate Skeletal Muscle Area Measurement on Computed Tomography Images

Kaushalya C Amarasinghe, Jamie Lopes, Julian Beraldo, Nicole Kiss, Nicholas Bucknell, Sarah Everitt, Price Jackson, Cassandra Litchfield, Linda Denehy, Benjamin J Blyth, Shankar Siva, Michael MacManus, David Ball, Jason Li, Nicholas Hardcastle

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

Background: Muscle wasting (Sarcopenia) is associated with poor outcomes in cancer patients. Early identification of sarcopenia ca..

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer

Alicia Corlett, Marc-Antoine Sani, Jessica Van Zuylekom, Ching-Seng Ang, Elisabeth von Guggenberg, Carleen Cullinane, Benjamin Blyth, Rodney J Hicks, Peter D Roselt, Philip E Thompson, Craig A Hutton, Mohammad B Haskali

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

Proteins adopt unique folded secondary and tertiary structures that are responsible for their remarkable biological properties. Th..

Single-arm prospective interventional study assessing feasibility of using gallium-68 ventilation and perfusion PET/CT to avoid functional lung in patients with stage III non-small cell lung cancer

Nicholas Bucknell, Nicholas Hardcastle, Price Jackson, Michael Hofman, Jason Callahan, Peter Eu, Amir Iravani, Rhonda Lawrence, Olga Martin, Mathias Bressel, Beverley Woon, Benjamin Blyth, Michael MacManus, Keelan Byrne, Daniel Steinfort, Tomas Kron, Gerard Hanna, David Ball, Shankar Siva

Journal article  |  2020  |  BMJ OPEN

BACKGROUND: In the curative-intent treatment of locally advanced lung cancer, significant morbidity and mortality can result from ..

Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state

Maria Gomolka, Benjamin Blyth, Michel Bourguignon, Christophe Badie, Annette Schmitz, Christopher Talbot, Christoph Hoeschen, Sisko Salomaa

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Purpose: The workshop on 'Individual Radiosensitivity and Radiosusceptibility' organized by MELODI and CONCERT on Malta in 2018, e..

Establishing the Japan-Store house of animal radiobiology experiments (J-SHARE), a large-scale necropsy and histopathology archive providing international access to important radiobiology data

Takamitsu Morioka, Benjamin J Blyth, Tatsuhiko Imaoka, Mayumi Nishimura, Hiroshi Takeshita, Takeo Shimomura, Jun Ohtake, Atsuro Ishida, Paul Schofield, Bernd Grosche, Ulrike Kulka, Yoshiya Shimada, Yutaka Yamada, Shizuko Kakinuma

Journal article  |  2019  |  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Purpose: Projects evaluating the effects of radiation, within the National Institutes of Quantum and Radiological Science and Tech..

Differential effect of parity on rat mammary carcinogenesis after pre- or post-pubertal exposure to radiation

Masaru Takabatake, Kazuhiro Daino, Tatsuhiko Imaoka, Benjamin J Blyth, Toshiaki Kokubo, Yukiko Nishimura, Kaye Showler, Ayaka Hosoki, Hitomi Moriyama, Mayumi Nishimura, Shizuko Kakinuma, Masahiro Fukushi, Yoshiya Shimada

Journal article  |  2018  |  Scientific Reports

Radiation exposure during the peri-pubertal period is a proven risk factor for breast cancer, whereas parity is an established pro..

Radiation therapy-induced metastasis: radiobiology and clinical implications

Benjamin J Blyth, Aidan J Cole, Michael P MacManus, Olga A Martin

Journal article  |  2018  |  CLINICAL & EXPERIMENTAL METASTASIS

Radiation therapy is an effective means of achieving local control in a wide range of primary tumours, with the reduction in the s..

The paradox of adaptive responses and iso-effect per fraction The history of dose fractionation symposium: September 2015, RRS annual meeting

Benjamin J Blyth

Journal article  |  2018  |  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

PURPOSE: Despite decades of research into radiation-induced adaptive responses, where prior irradiation changes the response to su..