Melinda Ashcroft

Reflex Detection of Ciprofloxacin Resistance in Neisseria gonorrhoeae by Use of the SpeeDx ResistancePlus GC Assay

Darren YJ Lee, Melinda M Ashcroft, Eric PF Chow, Michelle Sait, Vesna De Petra, Marlene Tschaepe, Sigrid Lange, George Taiaroa, Catriona S Bradshaw, David M Whiley, Christopher K Fairley, Benjamin P Howden, Marcus Y Chen, Shivani Pasricha, Deborah A Williamson

Journal article  |  2021  |  JOURNAL OF CLINICAL MICROBIOLOGY

Resistance-guided therapy (RGT) for gonorrhea may reduce unnecessary use of broad-spectrum antibiotics. When reflexed from the Apt..

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

Allison L Hicks, Stephen M Kissler, Tatum D Mortimer, Kevin C Ma, George Taiaroa, Melinda Ashcroft, Deborah A Williamson, Marc Lipsitch, Yonatan H Grad

Journal article  |  2020  |  ELIFE

Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate ..

Strain and lineage-level methylome heterogeneity in the multi-drug resistant pathogenic Escherichia coli ST101 clone

Melinda Ashcroft, Brian Forde, Minh-Duy Phan, Kate Peters, Leah Roberts, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, David Paterson, Timothy Walsh, Mark Schembri, Scott Beatson

Journal article  |  2020

Escherichia coli Sequence Type (ST)101 is an emerging, multi-drug resistant lineage associated with carbapenem resistance. We rece..

Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants

Allison Hicks, Stephen Kissler, Tatum Mortimer, Kevin Ma, George Taiaroa, Melinda Ashcroft, Deborah Williamson, Marc Lipsitch, Yonatan Grad

Journal article  |  2020

Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate ..

INCIDENCE AND DURATION OF INCIDENT OROPHARYNGEAL GONORRHOEA AND CHLAMYDIA INFECTIONS AMONG MEN WHO HAVE SEX WITH MEN: A PROSPECTIVE COHORT STUDY

EPF Chow, LA Vodstrcil, DA Williamson, K Maddaford, JS Hocking, MM Ashcroft, V De Petra, CS Bradshaw, CK Fairley

Journal article  |  2020  |  SEXUAL HEALTH

OBJECTIVES: This prospective cohort study aimed to determine the natural history and incidence of oropharyngeal gonorrhoea and chl..

GENOMIC ASSESSMENT OF WITHIN-HOST POPULATION VARIATION IN NEISSERIA GONORRHOEAE: IMPLICATIONS FOR GONORRHOEA TRANSMISSION

MM Ashcroft, EPF Chow, DYJ Lee, G Taiaroa, BP Howden, CK Fairley, DA Williamson

Journal article  |  2020  |  SEXUAL HEALTH

ABSTRACT Objectives Mathematical modelling and genomic analyses are powerful methods for investigating the transmission dynamics o..

Genomic characterisation and context of the blaNDM-1 carbapenemase in Escherichia coli ST101

Melinda Ashcroft, Brian Forde, Minh-Duy Phan, Kate Peters, Andrew Henderson, Steven Hancock, Leah Roberts, Rhys White, Rhys White, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, David Paterson, Timothy Walsh, Mark Schembri, Scott Beatson

Journal article  |  2019

Carbapenems are last-resort antibiotics; however, the spread of plasmid-encoded carbapenemases such as the New Delhi metallo-β-lac..

Genetic variation in IRF4 expression modulates growth characteristics, tyrosinase expression and interferon-gamma response in melanocytic cells

Yash Chhabra, Hilary XL Yong, Mitchell E Fane, Arish Soogrim, Wen Lim, Dayana Nur Mahiuddin, Reuben SQ Kim, Melinda Ashcroft, Scott A Beatson, Stephen A Ainger, Darren J Smit, Kasturee Jagirdar, Graeme J Walker, Richard A Sturm, Aaron G Smith

Journal article  |  2018  |  PIGMENT CELL & MELANOMA RESEARCH

A SNP within intron4 of the interferon regulatory factor4 (IRF4) gene, rs12203592*C/T, has been independently associated with pigm..

Sequential Acquisition of Virulence and Fluoroquinolone Resistance Has Shaped the Evolution of Escherichia coli ST131

Nouri L Ben Zakour, Areej S Alsheikh-Hussain, Melinda M Ashcroft, Thi Khanh Nhu Nguyen, Leah W Roberts, Mitchell Stanton-Cook, Mark A Schembri, Scott A Beatson

Journal article  |  2016  |  MBIO

UNLABELLED: Escherichia coli ST131 is the most frequently isolated fluoroquinolone-resistant (FQR) E. coli clone worldwide and a m..

Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone

Brian M Forde, Phan Minh-Duy, Jayde A Gawthorne, Melinda M Ashcroft, Mitchell Stanton-Cook, Sohinee Sarkar, Kate M Peters, Kok-Gan Chan, Teik Min Chong, Wai-Fong Yin, Mathew Upton, Mark A Schembri, Scott A Beatson

Journal article  |  2015  |  MBIO

UNLABELLED: Escherichia coli sequence type 131 (ST131) is a clone of uropathogenic E. coli that has emerged rapidly and disseminat..