Mitchell Lawrence

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition.

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  Mol Cancer Ther

Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologo..

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-d..

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies..

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M Winter, Luke A Selth, Amy R Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E Hickey, Wayne D Tilley, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence, Kaylene J Simpson

Journal article  |  2021  |  SLAS DISCOVERY

New treatments are required for advanced prostate cancer; however, there are fewer preclinical models of prostate cancer than othe..

Androgen receptor enhancer amplification in matched patient-derived xenografts of primary and castrate-resistant prostate cancer

Laura H Porter, Andrew Bakshi, David Pook, Ashlee Clark, David Clouston, John Kourambas, David L Goode, Gail P Risbridger, Renea A Taylor, Mitchell G Lawrence

Journal article  |  2021  |  JOURNAL OF PATHOLOGY

Amplifications of the androgen receptor (AR) occur in up to 80% of men with castration-resistant prostate cancer (CRPC). Recent st..

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment

Linda KH Teng, Brooke A Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N Lee, Michelle Richards, Ralf B Schittenhelm, Luc Furic, David L Goode, Mitchell G Lawrence, Renea A Taylor, Stuart J Ellem, Gail P Risbridger, Natalie L Lister

Journal article  |  2021  |  CANCERS

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patien..

Cancer Plasticity: The Role of mRNA Translation

Laura J Lee, David Papadopoli, Michael Jewer, Sonia del Rincon, Ivan Topisirovic, Mitchell G Lawrence, Lynne-Marie Postovit

Journal article  |  2021  |  TRENDS IN CANCER

Tumor progression is associated with dedifferentiated histopathologies concomitant with cancer cell survival within a changing, an..

Epigenetic regulation of OCT1 in multidrug-resistant patient-derived prostate cancer cells

Daisuke Obinata, Ken-ichi Takayama, Yutaka Suzuki, Mitchell Lawrence, Renea Taylor, Shahneen Sandhu, Gail Risbridger, Satoru Takahashi, Satoshi Inoue

Conference Proceedings  |  2021  |  CANCER SCIENCE

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

Nichola Johnson, Sarah Maguire, Anna Morra, Pooja Middha Kapoor, Katarzyna Tomczyk, Michael E Jones, Minouk J Schoemaker, Clare Gilham, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Caroline Baynes, Laura E Beane Freeman, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cance..

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

Rayzel C Fernandes, John Toubia, Scott Townley, Adrienne R Hanson, B Kate Dredge, Katherine A Pillman, Andrew G Bert, Jean M Winter, Richard Iggo, Rajdeep Das, Daisuke Obinata, Shahneen Sandhu, Gail P Risbridger, Renea A Taylor, Mitchell G Lawrence, Lisa M Butler, Amina Zoubeidi, Philip A Gregory, Wayne D Tilley, Theresa E Hickey, et al.

Journal article  |  2021  |  CELL REPORTS

Potent therapeutic inhibition of the androgen receptor (AR) in prostate adenocarcinoma can lead to the emergence of neuroendocrine..