Mitchell Lawrence

Cancer Plasticity: The Role of mRNA Translation

Laura J Lee, David Papadopoli, Michael Jewer, Sonia del Rincon, Ivan Topisirovic, Mitchell G Lawrence, Lynne-Marie Postovit

Journal article  |  2021  |  Trends in Cancer

Tumor progression is associated with dedifferentiated histopathologies concomitant with cancer cell survival within a changing, an..

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul DP Pharoah, Sander Canisius, Zumuruda Abu-Ful, Irene L Andrulis, Hoda Anton-Culver, Kristan J Aronson, Annelie Augustinsson, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2020  |  American Journal of Human Genetics

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing ..

Cancer-associated fibroblasts of the prostate promote a compliant and more invasive phenotype in benign prostate epithelial cells

A Jaeschke, A Jacobi, MG Lawrence, GP Risbridger, M Frydenberg, ED Williams, I Vela, DW Hutmacher, LJ Bray, A Taubenberger

Journal article  |  2020  |  Materials Today Bio

Reciprocal interactions between prostate epithelial cells and their adjacent stromal microenvironment not only are essential for t..

Comprehensive evaluation of targeted multiplex bisulphite PCR sequencing for validation of DNA methylation biomarker panels

Dilys Lam, Phuc-Loi Luu, Jenny Z Song, Wenjia Qu, Gail P Risbridger, Mitchell G Lawrence, Jennifer Lu, Matt Trau, Darren Korbie, Susan J Clark, Ruth Pidsley, Clare Stirzaker

Journal article  |  2020  |  Clinical Epigenetics

BACKGROUND: DNA methylation is a well-studied epigenetic mark that is frequently altered in diseases such as cancer, where specifi..

Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

Mitchell G Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A Taylor, Gail P Risbridger, Susan J Clark

Journal article  |  2020  |  Clinical Epigenetics

BACKGROUND: Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in tu..

Knowing what's growing: Why ductal and intraductal prostate cancer matter

Mitchell G Lawrence, Laura H Porter, David Clouston, Declan G Murphy, Mark Frydenberg, Renea A Taylor, Gail P Risbridger

Journal article  |  2020  |  Science Translational Medicine

New patient-derived models of castrate-sensitive and castrate-resistant prostate cancer

Mitchell Lawrence, David Clouston, Mark Frydenberg, Declan G Murphy, Carmel Jo Pezaro, David William Pook, Heather Thorne, Shahneen Kaur Sandhu, Roxanne Toivanen, Renea Taylor, Gail Risbridger

Conference Proceedings  |  2020  |  JOURNAL OF CLINICAL ONCOLOGY

New patient-derived models of castrate-sensitive and castrate-resistant prostate cancer.

Mitchell Lawrence, David Clouston, Mark Frydenberg, Declan G Murphy, Carmel Jo Pezaro, David William Pook, Heather Thorne, Shahneen Kaur Sandhu, Roxanne Toivanen, Renea Taylor, Gail Risbridger

Conference Proceedings  |  2020  |  Journal of Clinical Oncology

151 Background: There are fewer preclinical models of prostate cancer compared to other common tumours. New models that represent..

New combination therapies for castration-resistant prostate cancer

Mitchell G Lawrence, Laura H Porter, Daisuke Obinata, Shahneen Sandhu, Luke A Selth, Stephen Q Wong, Nicholas Choo, David Pook, Carmel J Pezaro, David L Goode, Ashlee K Clark, Melissa Papargiris, Roxanne Toivanen, Scott M Dehm, Scott M CASCADE, Scott M kConfab, Heather Thorne, Wayne D Tilley, Richard B Pearson, Ross D Hannan, et al.

Conference Proceedings  |  Oncology Abstracts