Mitchell Lawrence

Abstract 2155: PMR-116, a novel inhibitor of ribosome biogenesis with antitumor activity in preclinical models of prostate cancer

Alisee Huglo, Richard Rebello, Mitchell Lawrence, Gail Risbridger, Denis Drygin, Mustapha Haddach, Katherine Hannan, Ross Hannan, Luc Furic

Conference Proceedings  |  2022  |  Cancer Research

Abstract Advanced prostate cancer is characterised by mutations and amplifications of genes involved in regulating ..

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G Lawrence, Renea A Taylor, Gail P Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue

Journal article  |  2022  |  SCIENTIFIC REPORTS

Androgen and androgen receptor (AR) targeted therapies are the main treatment for most prostate cancer (PC) patients. Although AR ..

Identification of OCT1 target genes involved in progression of castration-resistant AR-null prostate cancer

Daisuke Obinata, Kenichi Takayama, Daigo Funakoshi, Mitchell Lawrence, Renea Taylor, Shahneen Sandhu, Gail Risbridger

Conference Proceedings  |  2022  |  CANCER SCIENCE

CX-5461 Sensitizes DNA Damage Repair-proficient Castrate-resistant Prostate Cancer to PARP Inhibition

Mitchell G Lawrence, Laura H Porter, Nicholas Choo, David Pook, Jeremy P Grummet, Carmel J Pezaro, Shahneen Sandhu, Susanne Ramm, Jennii Luu, Andrew Bakshi, David L Goode, Elaine Sanij, Richard B Pearson, Ross D Hannan, Kaylene J Simpson, Renea A Taylor, Gail P Risbridger, Luc Furic

Journal article  |  2021  |  MOLECULAR CANCER THERAPEUTICS

Monotherapy with PARP inhibitors is effective for the subset of castrate-resistant prostate cancer (CRPC) with defects in homologo..

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Gail P Risbridger, Ashlee K Clark, Laura H Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L Lister, David Pook, Carmel J Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B Madsen, Hong Wang, Michelle G Richards, Birunthi Niranjan, Samantha O'Dea, Linda Teng, William Wheelahan, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-d..

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Adinda Baten, Laura E Beane Freeman, Heiko Becher, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, et al.

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies..

High-Throughput Imaging Assay for Drug Screening of 3D Prostate Cancer Organoids

Nicholas Choo, Susanne Ramm, Jennii Luu, Jean M Winter, Luke A Selth, Amy R Dwyer, Mark Frydenberg, Jeremy Grummet, Shahneen Sandhu, Theresa E Hickey, Wayne D Tilley, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence, Kaylene J Simpson

Journal article  |  2021  |  SLAS DISCOVERY

New treatments are required for advanced prostate cancer; however, there are fewer preclinical models of prostate cancer than othe..

Androgen receptor enhancer amplification in matched patient-derived xenografts of primary and castrate-resistant prostate cancer

Laura H Porter, Andrew Bakshi, David Pook, Ashlee Clark, David Clouston, John Kourambas, David L Goode, Gail P Risbridger, Renea A Taylor, Mitchell G Lawrence

Journal article  |  2021  |  JOURNAL OF PATHOLOGY

Amplifications of the androgen receptor (AR) occur in up to 80% of men with castration-resistant prostate cancer (CRPC). Recent st..

Mast Cell-Derived SAMD14 Is a Novel Regulator of the Human Prostate Tumor Microenvironment

Linda KH Teng, Brooke A Pereira, Shivakumar Keerthikumar, Cheng Huang, Birunthi Niranjan, Sophie N Lee, Michelle Richards, Ralf B Schittenhelm, Luc Furic, David L Goode, Mitchell G Lawrence, Renea A Taylor, Stuart J Ellem, Gail P Risbridger, Natalie L Lister

Journal article  |  2021  |  CANCERS

Mast cells (MCs) are important cellular components of the tumor microenvironment and are significantly associated with poor patien..

Cancer Plasticity: The Role of mRNA Translation

Laura J Lee, David Papadopoli, Michael Jewer, Sonia del Rincon, Ivan Topisirovic, Mitchell G Lawrence, Lynne-Marie Postovit

Journal article  |  2021  |  TRENDS IN CANCER

Tumor progression is associated with dedifferentiated histopathologies concomitant with cancer cell survival within a changing, an..