Rubaiyea Farrukee

Isoforms of Human MARCH1 Differ in Ability to Restrict Influenza A Viruses Due to Differences in Their N Terminal Cytoplasmic Domain

Fernando Villalon-Letelier, Rubaiyea Farrukee, Sarah L Londrigan, Andrew G Brooks, Patrick C Reading

Journal article  |  2022  |  VIRUSES-BASEL

MARCH1 and MARCH8 are closely related E3 ubiquitin ligases that ubiquitinate an overlapping spectrum of host proteins and restrict..

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection

Lara SU Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L Londrigan, Andrew G Brooks, Aeron C Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF INFECTIOUS DISEASES

Infections caused by human respiratory syncytial virus (RSV) are associated with substantial rates of morbidity and mortality. Tre..

Predicting Permissive Mutations That Improve the Fitness of A(H1N1)pdm09 Viruses Bearing the H275Y Neuraminidase Substitution

Rubaiyea Farrukee, Vithiagaran Gunalan, Sebastian Maurer-Stroh, Patrick C Reading, Aeron C Hurt

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Oseltamivir-resistant influenza viruses arise due to amino acid mutations in key residues of the viral neuraminidase (NA). These c..

Infection with different human influenza A subtypes affects the period of susceptibility to secondary bacterial infections in ferrets

Edin J Mifsud, Rubaiyea Farrukee, Aeron C Hurt, Patrick C Reading, Ian G Barr

Journal article  |  2022  |  FEMS Microbes

Abstract It is well-established that influenza virus infections predispose individuals to secondary bacterial infec..

Mouse Mx1 Inhibits Herpes Simplex Virus Type 1 Genomic Replication and Late Gene Expression In Vitro and Prevents Lesion Formation in the Mouse Zosteriform Model

Melkamu B Tessema, Rubaiyea Farrukee, Christopher E Andoniou, Mariapia A Degli-Esposti, Clare Oates, James B Barnes, Linda M Wakim, Andrew G Brooks, Sarah L Londrigan, Patrick C Reading

Journal article  |  2022  |  JOURNAL OF VIROLOGY

Myxovirus resistance (Mx) proteins are dynamin-like GTPases that are inducible by interferons (IFNs) following virus infections. M..

Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model

Leo YY Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S Barclay, Aeron C Hurt

Journal article  |  2021  |  PLOS PATHOGENS

Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patient..

Host Cell Restriction Factors of Paramyxoviruses and Pneumoviruses

Rubaiyea Farrukee, Malika Ait-Goughoulte, Philippa M Saunders, Sarah L Londrigan, Patrick C Reading

Journal article  |  2020  |  VIRUSES-BASEL

The paramyxo- and pneumovirus family includes a wide range of viruses that can cause respiratory and/or systemic infections in hum..

Utilising animal models to evaluate oseltamivir efficacy against influenza A and B viruses with reduced in vitro susceptibility

Rubaiyea Farrukee, Celeste Ming-Kay Tai, Ding Yuan Oh, Danielle E Anderson, Vithiagaran Gunalan, Martin Hibberd, Gary Yuk-Fai Lau, Ian G Barr, Veronika von Messling, Sebastian Maurer-Stroh, Aeron C Hurt

Journal article  |  2020  |  PLOS PATHOGENS

The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid s..

A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions

Paulina Koszalka, Rubaiyea Farrukee, Edin Mifsud, Dhanasekaran Vijaykrishna, Aeron C Hurt

Journal article  |  2020  |  INFLUENZA AND OTHER RESPIRATORY VIRUSES

Baloxavir marboxil is a novel endonuclease inhibitor licensed for treatment of otherwise healthy or high-risk individuals infected..

Characterization of substitutions in the neuraminidase of A(H7N9) influenza viruses selected following serial passage in the presence of different neuraminidase inhibitors

R Farrukee, J Butler, PC Reading, AC Hurt

Journal article  |  2019  |  ANTIVIRAL RESEARCH

Avian A(H7N9) infections in humans have been reported in China since 2013 and are of public health concern due to their severity a..