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Prof

Alastair Sloan

Head Of School - Melbourne Dental School
Melbourne Dental School
Stem Cells
liposomal carriers for antimicrobial agents for dental and orthopaedic infection
3D culture models and the 3Rs for understanding tissue repair and response to infection
In vitro / ex vivo modelling of tissue infection and repair
Dental pulp stem cells
Bone
periodontal ligament stem cells
Orthopaedics
targetted antimicrobial drug delivery
Alastair Sloan's Profile Picture
Prof

Alastair Sloan

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Regenerative Dentistry
Alastair Sloan's Profile Picture
Prof

Alastair Sloan

 

Alastair obtained his BSc (Hons) in Biomedical Sciences from the University of Wales in 1993 and his PhD in Oral Biology and Pathology from The University of Birmingham, UK in 1997 in the Faculty of Medicine and Dentistry. Following postdoctoral research he was appointed to a Lectureship in Oral Biology at the School of Dentistry in The University of Birmingham in 2000.

In 2005, he moved to the School of Dentistry, Cardiff University and was awarded his personal chair in 2012. He was Head of Oral and Biomedical Sciences at the School of Dentistry between 2010-2015, Director of International (2012-2015) and Director of Research (2015-2017). Between 2015-2017 he was Chair/Director of the Cardiff Institute for Tissue Engineering and Repair (CITER), a cross-University research network. He was appointed Head of School in 2017, a post which he held until January 2020 when he relocated to The University of Melbourne to take up his present role as Head of School of the Melbourne Dental School. He is a Fellow of the Higher Education Academy and a Fellow of the Royal Society of Biology (FRSB). In 2020 he was elected Honorary Fellow of the International College of Dentists (FICD).

Alastair's research is multi-disciplinary and in the broad field of mineralised connective tissues. He is interested in the reparative potential and behaviour of the dentine-pulp complex and bone, specifically the potential therapeutic manipulation of the dental pulp stem cells (DPSCs) and the cellular and molecular responses of these cells to natural biomatrices and compromised biological environments to understand their functional behaviour during tissue injury. Complimentary to this work he is also interested understanding the heterogeneity within dental pulp progenitor populations and their function in 3D environments in vitro. In addition, he is interested in the potential therapeutic roles of these DPSCs in the wider context of regenerative biology, specifically neural repair and smooth muscle regeneration for bladder tissue repair.

Research is also focussed on understanding the dentinogenic and osteoinductive properties of dentine and bone matrices to facilitate novel tissue engineering methodologies and natural regenerative processes. Knowledge in these areas will allow us to develop ways of exploiting endogenous growth factor involvement in mineralised tissue repair for novel treatment modalities in restorative dentistry, implantology and orthopaedics. This has allowed me to develop a research programme directly related to the development of novel clinical therapies and methods in relation to dentistry and orthopaedics regarding tissue regeneration and repair.

In relation to this we are also heavily focussed on understanding bacterial invasion and attachment in dental and bone infections and development of novel antimicrobial carriers / restorative materials for clinical endodontics and orthopaedics. We have established liposomal nanocarriers for antimicrobial delivery and prototype restorative materials and model systems to better understand the nature of the bacterial / pulp environment during pulpal infection. I have a long standing interest in developing novel in vitro / ex vivo organ 3D culture model systems for mineralising tissues to provide innovative models for tissue regeneration/engineering and testing of novel therapeutic agents and advancing the 3Rs (reduction, replacement refinement) in biomedical research and bioengineering.

Scholarly Works

Displaying the 96 most recent scholarly works by Alastair Sloan.

Honours, Awards and Fellowships

2011

Distinguished Scientist, Young Investigator Award

International Association for Dental Research

1998

Mineralised Tissue Research Prize

British Society for Oral and Dental Research

2020

FICD - Fellow of the International College of Dentists


2003

FHEA - Fellow of the Higher Education Academy (UK)


4

Awards

Credentials

Positions


Head Of School - Melbourne Dental School

Melbourne Dental School

Member

International Association for Dental Research, Australian and New Zealand Division

Fellow, Royal Society Of Biology (Frsb)

Royal Society of Biology

Member

Tissue Engineering and Regenerative Medicine International Society, Inc (TERMIS)

Member

Tissue and Cell Engineering Society, UK

Member

International Assocation for Dental Research

Member

British Society for Oral and Dental Research

Education


Learning and Teaching in Higher Education

The University of Birmingham

Oral Biology and Pathology

The University of Birmingham

Biomedical Sciences

University of Wales