Natasha Brockwell

High-content siRNA 3D co-cultures to identify myoepithelial cell-derived breast cancer suppressor proteins

Hendrika M Duivenvoorden, Natasha K Brockwell, Cameron J Nowell, Kaylene J Simpson, Belinda S Parker

Journal article  |  2021  |  SCIENTIFIC DATA

Understanding how cancer cells interact with the surrounding microenvironment early in breast cancer development can provide insig..

Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone

Katie L Owen, Linden J Gearing, Damien J Zanker, Natasha K Brockwell, Weng Hua Khoo, Daniel L Roden, Marek Cmero, Stefano Mangiola, Matthew K Hong, Alex J Spurling, Michelle McDonald, Chia-Ling Chan, Anupama Pasam, Ruth J Lyons, Hendrika M Duivenvoorden, Andrew Ryan, Lisa M Butler, John M Mariadason, Tri Giang Phan, Vanessa M Hayes, et al.

Journal article  |  2020  |  EMBO REPORTS

The latency associated with bone metastasis emergence in castrate-resistant prostate cancer is attributed to dormancy, a state in ..

Preliminary study highlights the potential of immune checkpoint inhibitors in sarcomatoid mesothelioma

Natasha K Brockwell, Muhammad Alamgeer, Beena Kumar, Gareth Rivalland, Thomas John, Belinda S Parker

Journal article  |  2020  |  TRANSLATIONAL LUNG CANCER RESEARCH

Background: Malignant pleural mesothelioma (MPM) is well known as an aggressive disease with poor survival. This has sparked trial..

Intratumoral administration of the Toll-like receptor 7/8 agonist 3M-052 enhances interferon-driven tumor immunogenicity and suppresses metastatic spread in preclinical triple-negative breast cancer

Damien J Zanker, Alex J Spurling, Natasha K Brockwell, Katie L Owen, Jasmine M Zakhour, Tina Robinson, Hendrika M Duivenvoorden, Paul J Hertzog, Stefanie R Mullins, Robert W Wilkinson, Belinda S Parker

Journal article  |  2020  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Loss of tumor-inherent type I interferon (IFN) signalling has been closely linked to accelerated metastatic progressio..

JAK-STAT Signaling: A Double-Edged Sword of Immune Regulation and Cancer Progression

Katie L Owen, Natasha K Brockwell, Belinda S Parker

Journal article  |  2019  |  CANCERS

Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates almost all immune regulatory processes..

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC

Natasha K Brockwell, Jai Rautela, Katie L Owen, Linden J Gearing, Siddhartha Deb, Kate Harvey, Alex Spurling, Damien Zanker, Chia-Ling Chan, Helen E Cumming, Niantao Deng, Jasmine M Zakhour, Hendrika M Duivenvoorden, Tina Robinson, Marion Harris, Michelle White, Jane Fox, Corinne Ooi, Beena Kumar, Jacqui Thomson, et al.

Journal article  |  2019  |  NPJ PRECISION ONCOLOGY

Patients diagnosed with triple negative breast cancer (TNBC) have an increased risk of rapid metastasis compared to other subtypes..