Kazuhide Shaun Okuda

The RNA helicase Ddx21 controls Vegfc-driven developmental lymphangiogenesis by balancing endothelial cell ribosome biogenesis and p53 function

Katarzyna Koltowska, Kazuhide S Okuda, Marleen Gloger, Maria Rondon-Galeano, Elizabeth Mason, Jiachen Xuan, Stefanie Dudczig, Huijun Chen, Hannah Arnold, Renae Skoczylas, Neil Bower, Scott Paterson, Anne Karine Lagendijk, Gregory J Baillie, Ignaty Leshchiner, Cas Simons, Kelly A Smith, Wolfram Goessling, Joan K Heath, Richard B Pearson, et al.

Journal article  |  2021  |  NATURE CELL BIOLOGY

The development of a functional vasculature requires the coordinated control of cell fate, lineage differentiation and network gro..

Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis

Kazuhide S Okuda, Mikaela Keyser, David B Gurevich, Caterina Sturtzel, Elizabeth A Mason, Scott Patterson, Huijun Chen, Mark Scott, Nicholas D Condon, Paul Martin, Martin Distel, Benjamin M Hogan

Journal article  |  2021  |  ELIFE

The formation of new blood vessel networks occurs via angiogenesis during development, tissue repair, and disease. Angiogenesis is..

3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

Kazuhide S Okuda, Mei Fong Ng, Nur Faizah Ruslan, Neil I Bower, Dedrick Soon Seng Song, Huijun Chen, Sungmin Baek, Philip S Crosier, Katarzyna Koltowska, Jonathan W Astin, Pei Jean Tan, Benjamin M Hogan, Vyomesh Patel

Journal article  |  2021  |  Pharmaceuticals

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, includin..

Localised Collagen2a1 secretion supports lymphatic endothelial cell migration in the zebrafish embryo

Smrita Chaudhury, Kazuhide S Okuda, Katarzyna Koltowska, Anne K Lagendijk, Scott Paterson, Gregory J Baillie, Cas Simons, Kelly A Smith, Benjamin M Hogan, Neil Bower

Journal article  |  2020  |  DEVELOPMENT

The lymphatic vasculature develops primarily from pre-existing veins. A pool of lymphatic endothelial cells (LECs) first sprouts f..

Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish

Kazuhide S Okuda, Benjamin M Hogan

Journal article  |  2020  |  FRONTIERS IN PHYSIOLOGY

The formation of the vertebrate vasculature involves the acquisition of endothelial cell identities, sprouting, migration, remodel..

Evolutionary Differences in the Vegf/Vegfr Code Reveal Organotypic Roles for the Endothelial Cell Receptor Kdr in Developmental Lymphangiogenesis

Adam J Vogrin, Neil Bower, Menachem J Gunzburg, Sally Roufail, Kazuhide S Okuda, Scott Paterson, Stephen J Headey, Steven A Stacker, Benjamin M Hogan, Marc G Achen

Journal article  |  2019  |  CELL REPORTS

Lymphatic vascular development establishes embryonic and adult tissue fluid balance and is integral in disease. In diverse vertebr..

Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors

Tiffany CY Eng, Wenxuan Chen, Kazuhide S Okuda, June P Misa, Yvonne Padberg, Kathryn E Crosier, Philip S Crosier, Christopher J Hall, Stefan Schulte-Merker, Benjamin M Hogan, Jonathan W Astin

Journal article  |  2019  |  EMBO REPORTS

Lymphatic vessels are known to be derived from veins; however, recent lineage-tracing experiments propose that specific lymphatic ..

Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

Lin Grimm, Hiroyuki Nakajima, Smrita Chaudhury, Neil Bower, Kazuhide S Okuda, Andrew G Cox, Natasha L Harvey, Katarzyna Koltowska, Naoki Mochizuki, Benjamin M Hogan

Journal article  |  2019  |  ELIFE

Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, pr..

The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage

Sungmin Baek, Tae Gyu Oh, Genevieve Secker, Drew L Sutton, Kazuhide S Okuda, Scott Paterson, Neil I Bower, John Toubia, Katarzyna Koltowska, Samuel J Capon, Gregory J Baillie, Cas Simons, George EO Muscat, Anne K Lagendijk, Kelly A Smith, Natasha L Harvey, Benjamin M Hogan

Journal article  |  2019  |  DEVELOPMENTAL CELL

The correct assignment of cell fate within fields of multipotent progenitors is essential for accurate tissue diversification. The..

Current Perspectives on Nasopharyngeal Carcinoma

Hui Mei Lee, Kazuhida Shaun Okuda, Fermin E Gonzalez, Vyomesh Patel

Book Chapter  |  2019  |  Advances in Experimental Medicine and Biology

Of the ~129,079 new cases of nasopharyngeal carcinoma (NPC) and 72,987 associated deaths estimated for 2018, the majority will be ..