Elyse Dunn

ALT control, delete: FANCM as an anti-cancer target in Alternative Lengthening of Telomeres

Julienne J O'Rourke, Rohan Bythell-Douglas, Elyse A Dunn, Andrew J Deans

Journal article  |  2019  |  Nucleus

Break-induced replication is a specific type of DNA repair that has a co-opted role in telomere extension by telomerase-negative c..

Oxidative phosphorylation as a target space for tuberculosis: Success, caution, and future directions

GM Cook, K Hards, E Dunn, A Heikal, Y Nakatani, C Greening, DC Crick, FL Fontes, K Pethe, E Hasenoehrl, M Berney

Book Chapter  |  2017

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.

Gregory M Cook, Kiel Hards, Elyse Dunn, Adam Heikal, Yoshio Nakatani, Chris Greening, Dean C Crick, Fabio L Fontes, Kevin Pethe, Erik Hasenoehrl, Michael Berney

Journal article  |  2017  |  Microbiology Spectrum

The emergence and spread of drug-resistant pathogens, and our inability to develop new antimicrobials to combat resistance, have i..

The mechanism of catalysis by type-II NADH:quinone oxidoreductases.

James N Blaza, Hannah R Bridges, David Aragão, Elyse A Dunn, Adam Heikal, Gregory M Cook, Yoshio Nakatani, Judy Hirst

Journal article  |  2017  |  Scientific Reports

Type II NADH:quinone oxidoreductase (NDH-2) is central to the respiratory chains of many organisms. It is not present in mammals s..

Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening.

Elyse A Dunn, Gregory M Cook, Adam Heikal

Journal article  |  2016  |  Data in Brief

The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see "Inhibitors of type I..

Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins.

Elyse A Dunn, Gregory M Cook, Adam Heikal

Journal article  |  2016  |  Journal of Microbiological Methods

This study compared detergent-solubilised (soluble) and lipid-reconstituted (proteoliposome) protein to establish a high-throughpu..

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis.

Elyse A Dunn, Marina Roxburgh, Lesley Larsen, Robin AJ Smith, Alexander D McLellan, Adam Heikal, Michael P Murphy, Gregory M Cook

Journal article  |  2014  |  Bioorganic & Medicinal Chemistry

Tuberculosis (TB) is a difficult to treat disease caused by the bacterium Mycobacterium tuberculosis. The need for improved therap..

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.

Adam Heikal, Yoshio Nakatani, Elyse Dunn, Marion R Weimar, Catherine L Day, Edward N Baker, J Shaun Lott, Leonid A Sazanov, Gregory M Cook

Journal article  |  2014  |  Molecular Microbiology

Non-proton pumping type II NADH dehydrogenase (NDH-2) plays a central role in the respiratory metabolism of bacteria, and in the m..