Tanjina Kader

Evaluating statistical approaches to define clonal origin of tumours using bulk DNA sequencing: context is everything

Tanjina Kader, Magnus Zethoven, Kylie L Gorringe

Journal article  |  2022  |  GENOME BIOLOGY

Clonal analysis of tumour sequencing data enables the evaluation of the relationship of histologically distinct synchronous lesion..

Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus

Jovana R Gotovac, Tanjina Kader, Julia Milne, Kenji M Fujihara, Luis E Lara-Gonzalez, Kylie L Gorringe, Sangeetha N Kalimuthu, Madawa W Jayawardana, Cuong P Duong, Wayne A Phillips, Nicholas J Clemons

Journal article  |  2021  |  CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY

BACKGROUND & AIMS: Esophageal adenocarcinoma (EAC) develops from its precursor Barrett's esophagus through intermediate stages of ..

The TP53 mutation rate differs in breast cancers that arise in women with high or low mammographic density

Dane Cheasley, Lisa Devereux, Siobhan Hughes, Carolyn Nickson, Pietro Procopio, Grant Lee, Na Li, Vicki Pridmore, Kenneth Elder, G Bruce Mann, Tanjina Kader, Simone M Rowley, Stephen B Fox, David Byrne, Hugo Saunders, Kenji M Fujihara, Belle Lim, Kylie L Gorringe, Ian G Campbell

Journal article  |  2020  |  NPJ BREAST CANCER

Mammographic density (MD) influences breast cancer risk, but how this is mediated is unknown. Molecular differences between breast..

The prognostic significance of immune microenvironment in breast ductal carcinoma in situ

Michael S Toss, Asima Abidi, Dorothea Lesche, Chitra Joseph, Sakshi Mahale, Hugo Saunders, Tanjina Kader, Islam M Miligy, Andrew R Green, Kylie L Gorringe, Emad A Rakha

Journal article  |  2020  |  BRITISH JOURNAL OF CANCER

BACKGROUND: The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is ..

The genetic architecture of breast papillary lesions as a predictor of progression to carcinoma

Tanjina Kader, Kenneth Elder, Magnus Zethoven, Timothy Semple, Prue Hill, David L Goode, Niko Thio, Dane Cheasley, Simone M Rowley, David J Byrne, Jia-Min Pang, Islam M Miligy, Andrew R Green, Emad A Rakha, Stephen B Fox, G Bruce Mann, Ian G Campbell, Kylie L Gorringe

Journal article  |  2020  |  NPJ BREAST CANCER

Intraductal papillomas (IDP) are challenging breast findings because of their variable risk of progression to malignancy. The mole..

Ribose-cysteine protects against the development of atherosclerosis in apoE-deficient mice

Tanjina Kader, Carolyn M Porteous, Gregory T Jones, Nina Dickerhof, Vinod K Narayana, Dedreia Tull, Sreya Taraknath, Sally PA McCormick

Journal article  |  2020  |  PLOS ONE

Ribose-cysteine is a synthetic compound designed to increase glutathione (GSH) synthesis. Low levels of GSH and the GSH-dependent ..

Evaluation of genomic changes in ductal carcinoma in situ as potential biomarkers of recurrence risk

Dorothea Lesche, Hugo Saunders, Sakshi Mahale, Magnus Zenthoven, Siobhan Huges, Tanjina Kader, Niko Thio, Islam M Miligy, Jia-Min Pang, Andrew R Green, Emad A Rakha, Ian G Campbell, Stephen B Fox, Kylie Gorringe

Conference Proceedings  |  2020  |  CANCER RESEARCH

Abstract Routine breast cancer screening has increased detection of pre-invasive lesions such as ductal carcinoma i..

Abstract PD1-12: Identification of copy number alterations associated with the progression of high risk premalignant breast lesions to breast carcinoma

T Kader, P Hill, K Opeskin, DL Goode, K Elder, J-M Pang, SB Fox, GB Mann, IG Campbell, KL Gorringe

Conference Proceedings  |  2018  |  Cancer Research

Abstract Background: Atypical ductal hyperplasia (ADH) is common finding in the mammographic era, but has wide vari..