Ivanhoe K. H. Leung

An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C.

Nabangshu Sharma, Ries J Langley, Chatchakorn Eurtivong, Euphemia Leung, Ryan Joseph Dixon, Emily K Paulin, Shaun WP Rees, Lisa I Pilkington, David Barker, Jóhannes Reynisson, Ivanhoe KH Leung

Journal article  |  2021  |  Analytical Methods

The Bacillus cereus phosphatidylcholine-specific phospholipase C (PC-PLCBc) is an enzyme that catalyses the hydrolysis of phosphat..

Itaconate is a covalent inhibitor of theMycobacterium tuberculosisisocitrate lyase

BXC Kwai, AJ Collins, MJ Middleditch, J Sperry, G Bashiri, IKH Leung

Journal article  |  2021  |  RSC Medicinal Chemistry

Mycobacterium tuberculosis isocitrate lyases (ICLs) form a covalent adduct with itaconate through their catalytic cysteine residue..

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

Danilo Correddu, Nabangshu Sharma, Simranjeet Kaur, Kyriakos G Varnava, Naasson M Mbenza, Vijayalekshmi Sarojini, Ivanhoe KH Leung

Journal article  |  2020  |  Chemical Communications

Substrate specificity of polyphenol oxidase

Mark-Anthony McLarin, Ivanhoe KH Leung

Journal article  |  2020  |  Critical Reviews in Biochemistry and Molecular Biology

Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors

Lisa Pilkington, Kevin Sparrow, Shaun WP Rees, Emily K Paulin, Michelle van Rensburg, Chris Sun Xu, Ries J Langley, Ivanhoe KH Leung, Johannes Reynisson, Euphemia Leung, David Barker

Journal article  |  2020  |  European Journal of Medicinal Chemistry

Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents

Chatchakorn Eurtivong, Lisa I Pilkington, Michelle van Rensburg, Reuben M White, Harpreet Kaur Brar, Shaun Rees, Emily K Paulin, Chris Sun Xu, Nabangshu Sharma, Ivanhoe KH Leung, Euphemia Leung, David Barker, Johannes Reynisson

Journal article  |  2020  |  European Journal of Medicinal Chemistry

Sensory, Microbiological and Physicochemical Characterisation of Functional Manuka Honey Yogurts Containing Probiotic Lactobacillus reuteri DPC16

Anand Mohan, Joshua Hadi, Noemi Gutierrez-Maddox, Yu Li, Ivanhoe KH Leung, Yihuai Gao, Quan Shu, Siew-Young Quek

Journal article  |  2020  |  Foods

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

Tatyana M Khomenko, Alexandra L Zakharenko, Arina A Chepanova, Ekaterina S Ilina, Olga D Zakharova, Vasily I Kaledin, Valeriy P Nikolin, Nelly A Popova, Dina V Korchagina, Johannes Reynisson, Raina Chand, Daniel M Ayine-Tora, Jinal Patel, Ivanhoe KH Leung, Konstantin P Volcho, Nariman F Salakhutdinov, Olga I Lavrik

Journal article  |  2020  |  International Journal of Molecular Sciences

Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)

Oi Wei Mak, Raina Chand, Johannes Reynisson, Ivanhoe KH Leung

Journal article  |  2019  |  International Journal of Molecular Sciences

Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2

Ram Prasad Bhusal, Wanting Jiao, Brooke XC Kwai, Johannes Reynisson, Annabelle J Collins, Jonathan Sperry, Ghader Bashiri, Ivanhoe KH Leung

Journal article  |  2019  |  Nature Communications