Ivanhoe K. H. Leung

A novel tyrosine hyperoxidation enables selective peptide cleavage.

Shengping Zhang, Luis M De Leon Rodriguez, Freda F Li, Renjie Huang, Ivanhoe KH Leung, Paul WR Harris, Margaret A Brimble

Journal article  |  2022  |  Chem Sci

A novel tyrosine hyperoxidation enabling selective peptide cleavage is reported. The scission of the N-terminal amide bond of tyro..

Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors

Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Caitlin Clunie-O'Connor, Anthony Tumber, Ivanhoe KH Leung, Yi Min Ng, Thomas M Leissing, Afaf H El-Sagheer, Eidarus Salah, Tom Brown, Wei Shen Aik, Michael A McDonough, Christopher J Schofield

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

FTO catalyzes the Fe(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N6-methy..

Characterisation and optimisation of a novel laccase from Sulfitobacter indolifex for the decolourisation of organic dyes

Nabangshu Sharma, Ivanhoe KH Leung

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Laccases are multi‑copper oxidases that possess the potential for industrial wastewater treatments. In this study, a putative lacc..

Carbon Monoxide is an Inhibitor of HIF Prolyl Hydroxylase Domain 2

Naasson M Mbenza, Nawal Nasarudin, Praveen G Vadakkedath, Kamal Patel, AZ Ismail, Muhammad Hanif, L James Wright, Vijayalekshmi Sarojini, Christian G Hartinger, Ivanhoe KH Leung

Journal article  |  2021  |  CHEMBIOCHEM

Hypoxia-inducible factor prolyl hydroxylase domain 2 (PHD2) is an important oxygen sensor in animals. By using the CO-releasing mo..

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

Euphemia Leung, Jinal Patel, Jennifer A Hollywood, Ayesha Zafar, Petr Tomek, David Barker, Lisa I Pilkington, Michelle van Rensburg, Ries J Langley, Nuala A Helsby, Christopher J Squire, Bruce C Baguley, William A Denny, Johannes Reynisson, Ivanhoe KH Leung

Journal article  |  2021  |  ONCOLOGY AND THERAPY

Cancer chemotherapy sensitizers hold the key to maximizing the potential of standard anticancer treatments. We have a long-standin..

Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding

Oi Wei Mak, Nabangshu Sharma, Johannes Reynisson, Ivanhoe KH Leung

Journal article  |  2021  |  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Heat shock protein 90 (Hsp90) is an essential molecular chaperone that performs vital stress-related and housekeeping functions in..

An optimised MALDI-TOF assay for phosphatidylcholine-specific phospholipase C

Nabangshu Sharma, Ries J Langley, Chatchakorn Eurtivong, Euphemia Leung, Ryan Joseph Dixon, Emily K Paulin, Shaun WP Rees, Lisa Pilkington, David Barker, Johannes Reynisson, Ivanhoe KH Leung

Journal article  |  2021  |  ANALYTICAL METHODS

The Bacillus cereus phosphatidylcholine-specific phospholipase C (PC-PLCBc) is an enzyme that catalyses the hydrolysis of phosphat..

Novel Thermophilic Bacterial Laccase for the Degradation of Aromatic Organic Pollutants.

Nabangshu Sharma, Ivanhoe KH Leung

Journal article  |  2021  |  Front Chem

We identified a putative laccase from the thermophilic bacterium Geobacillus yumthangensis. The putative laccase was produced reco..

Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase

Brooke XC Kwai, Annabelle J Collins, Martin J Middleditch, Jonathan Sperry, Ghader Bashiri, Ivanhoe KH Leung

Journal article  |  2021  |  RSC MEDICINAL CHEMISTRY

Itaconate is a mammalian antimicrobial metabolite that inhibits the isocitrate lyases (ICLs) of Mycobacterium tuberculosis. Herein..

An investigation into the effect of ribosomal protein S15 phosphorylation on its intermolecular interactions by using phosphomimetic mutant

Danilo Correddu, Nabangshu Sharma, Simranjeet Kaur, Kyriakos G Varnava, Naasson M Mbenza, Vijayalekshmi Sarojini, Ivanhoe KH Leung

Journal article  |  2020  |  CHEMICAL COMMUNICATIONS

An investigation using recombinant ribosomal proteins and synthetic peptide models was conducted to uncover the effect of the intr..