James McCarthy

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.

Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R Trenholme, Julie Healer, Alan F Cowman, Emily M Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J Blanch, Matthew WA Dixon, Leann Tilley, Michael F Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, et al.

Journal article  |  2021  |  BMC Med

BACKGROUND: There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuate..

A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood- Stage or Mosquito Bite Induced Controlled Malaria Infection

Manon Alkema, Isaie J Reuling, Gerdie M de Jong, Kjerstin Lanke, Luc E Coffeng, Geert-Jan van Gemert, Marga van de Vegte-Bolmer, Quirijn de Mast, Reinout van Crevel, Karen Ivinson, Christian F Ockenhouse, James S McCarthy, Robert Sauerwein, Katharine A Collins, Teun Bousema

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: For malaria elimination efforts, it is important to better understand parasite transmission to mosquitoes and develop ..

Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans

Maria Rebelo, Rebecca Pawliw, Jeremy Gower, Lachlan Webb, Hayley Mitchell, Zuleima Pava, Rebecca E Watts, Miles P Davenport, James S McCarthy, David S Khoury

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Artemisinin derivatives are the leading class of antimalarial drugs due to their rapid onset of action and rapid clear..

Dormant Plasmodium falciparum Parasites in Human Infections Following Artesunate Therapy

Christopher Peatey, Nanhua Chen, Karryn Gresty, Karen Anderson, Paul Pickering, Rebecca Watts, Michelle L Gatton, James McCarthy, Qin Cheng

Journal article  |  2021  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Artemisinin monotherapy of Plasmodium falciparum infection is frequently ineffective due to recrudescence. Artemisinin..

Positron emission tomography and magnetic resonance imaging in experimental human malaria to identify organ-specific changes in morphology and glucose metabolism: A prospective cohort study

John Woodford, Ashley Gillman, Peter Jenvey, Jennie Roberts, Stephen Woolley, Bridget E Barber, Melissa Fernandez, Stephen Rose, Paul Thomas, Nicholas M Anstey, James S McCarthy

Journal article  |  2021  |  PLOS MEDICINE

BACKGROUND: Plasmodium vivax has been proposed to infect and replicate in the human spleen and bone marrow. Compared to Plasmodium..

Analytical validation of a real-time hydrolysis probe PCR assay for quantifying Plasmodium falciparum parasites in experimentally infected human adults

Claire YT Wang, Emma L Ballard, Zuleima Pava, Louise Marquart, Jane Gaydon, Sean C Murphy, David Whiley, Peter O'Rourke, James S McCarthy

Journal article  |  2021  |  MALARIA JOURNAL

BACKGROUND: Volunteer infection studies have become a standard model for evaluating drug efficacy against Plasmodium infections. M..

Parasite-Host Dynamics throughout Antimalarial Drug Development Stages Complicate the Translation of Parasite Clearance

Lydia Burgert, Sophie Zaloumis, Saber Dini, Louise Marquart, Pengxing Cao, Mohammed Cherkaoui, Nathalie Gobeau, James McCarthy, Julie A Simpson, Jorg J Mohrle, Melissa A Penny

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes prec..

Semimechanistic Pharmacokinetic and Pharmacodynamic Modeling of Piperaquine in a Volunteer Infection Study with Plasmodium falciparum Blood-Stage Malaria

Thanaporn Wattanakul, Mark Baker, Joerg Mohrle, Brett McWhinney, Richard M Hoglund, James S McCarthy, Joel Tarning

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Pipe..

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels

Jessica R Loughland, Tonia Woodberry, Damian Oyong, Kim A Piera, Fiona H Amante, Bridget E Barber, Matthew J Grigg, Timothy William, Christian R Engwerda, Nicholas M Anstey, James S McCarthy, Michelle J Boyle, Gabriela Minigo

Journal article  |  2021  |  MALARIA JOURNAL

BACKGROUND: Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a hae..

Development and evaluation of a new Plasmodium falciparum 3D7 blood stage malaria cell bank for use in malaria volunteer infection studies

Stephen D Woolley, Melissa Fernandez, Maria Rebelo, Stacey A Llewellyn, Louise Marquart, Fiona H Amante, Helen E Jennings, Rebecca Webster, Katharine Trenholme, Stephan Chalon, Joerg J Moehrle, James S McCarthy, Bridget E Barber

Journal article  |  2021  |  MALARIA JOURNAL

BACKGROUND: New anti-malarial therapeutics are required to counter the threat of increasing drug resistance. Malaria volunteer inf..