Daniel Priebbenow

Acyl silane directed Cp*Rh(iii)-catalysed alkylation/annulation reactions

Daniel L Priebbenow, Carol Hua

Journal article  |  2021  |  CHEMICAL COMMUNICATIONS

Studies into the Cp*Rh(iii)-catalysed hydroarylation of alkenes with aryl acyl silanes led to the discovery of a new synthetic str..

Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit

Lisa Barbaro, Gayathri Nagalingam, James A Triccas, Lendl Tan, Nicholas P West, Jonathan B Baell, Daniel L Priebbenow

Journal article  |  2021  |  RSC MEDICINAL CHEMISTRY

Despite promising efficacy, the clinical use of the anti-tubercular therapeutic bedaquiline has been restricted due to safety conc..

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines

Daniel L Priebbenow, Mitch Mathiew, Da-Hua Shi, Jitendra R Harjani, Julia G Beveridge, Marina Chavchich, Michael D Edstein, Sandra Duffy, Vicky M Avery, Robert T Jacobs, Stephen Brand, David M Shackleford, Wen Wang, Longjin Zhong, Given Lee, Erin Tay, Helena Barker, Elly Crighton, Karen L White, Susan A Charman, et al.

Journal article  |  2021  |  JOURNAL OF MEDICINAL CHEMISTRY

Novel 3,3'-disubstituted-5,5'-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites w..

Fluorinated Ketones as Trapping Reagents for Visible-Light-Induced Singlet Nucleophilic Carbenes

Daniel L Priebbenow, Rowan L Pilkington, Kyle N Hearn, Anastasios Polyzos

Journal article  |  2021  |  ORGANIC LETTERS

Singlet nucleophilic carbenes (SNCs) containing only one heteroatom donor remain underutilized in chemical synthesis. We recently ..

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents

Daniel L Priebbenow, David J Leaver, Nguyen Nghi, Benjamin Cleary, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, David M Shackleford, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, et al.

Journal article  |  2020  |  JOURNAL OF MEDICINAL CHEMISTRY

A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a uniqu..

Silicon-Derived Singlet Nucleophilic Carbene Reagents in Organic Synthesis

Daniel L Priebbenow

Journal article  |  2020  |  ADVANCED SYNTHESIS & CATALYSIS

Over fifty years ago, the 1,2-rearrangement of acylsilanes was first described by Adrian Brook and co-workers. This rearrangement ..

Insights into the Stability of Siloxy Carbene Intermediates and Their Corresponding Oxocarbenium Ions

Daniel L Priebbenow

Journal article  |  2019  |  JOURNAL OF ORGANIC CHEMISTRY

Siloxy carbenes, formed thermally or photochemically from acyl silanes via a 1,2-Brook rearrangement, are intriguing reactive inte..

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J Leaver, Benjamin Cleary, Nguyen Nghi, Daniel L Priebbenow, H Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A Charman, Karen L White, Kasiram Katneni, Matthew Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, et al.

Journal article  |  2019  |  JOURNAL OF MEDICINAL CHEMISTRY

A high-throughput screen for inhibitors of the histone acetyltransferase, KAT6A, led to identification of an aryl sulfonohydrazide..

Substituted Pyridazin-3(2H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Girdhar Singh Deora, Cheng Xue Qin, Elizabeth A Vecchio, Aaron J Debono, Daniel L Priebbenow, Ryan M Brady, Julia Beveridge, Silvia C Teguh, Deo Minh, Lauren T May, Guy Krippner, Rebecca H Ritchie, Jonathan B Baell

Journal article  |  2019  |  JOURNAL OF MEDICINAL CHEMISTRY

Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) ..

New synthetic approaches towards analogues of bedaquiline

Daniel L Priebbenow, Lisa Barbaro, Jonathan B Baell

Journal article  |  2016  |  ORGANIC & BIOMOLECULAR CHEMISTRY

Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control t..